1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. ML277

ML277 (Synonyms: CID-53347902)

Cat. No.: HY-12343 Purity: 99.43%
Handling Instructions

ML277(CID53347902) is a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator with EC50 of 270 nM.

For research use only. We do not sell to patients.

ML277 Chemical Structure

ML277 Chemical Structure

CAS No. : 1401242-74-7

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 113 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 113 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 103 In-stock
Estimated Time of Arrival: December 31
10 mg USD 187 In-stock
Estimated Time of Arrival: December 31
50 mg USD 766 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Description

ML277(CID53347902) is a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator with EC50 of 270 nM. IC50 value: 270 nM (EC50) [1] Target: K(v)7.1 activator ML277 was shown to be highly selective against other KCNQ channels (>100-fold selectivity versus KCNQ2 and KCNQ4) as well as against the distantly related hERG potassium channel.

Molecular Weight

471.59

Formula

C23H25N3O4S2

CAS No.
SMILES

O=C([[email protected]@H]1N(S(=O)(C2=CC=C(C)C=C2)=O)CCCC1)NC3=NC(C4=CC=C(OC)C=C4)=CS3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 56 mg/mL (118.75 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1205 mL 10.6024 mL 21.2049 mL
5 mM 0.4241 mL 2.1205 mL 4.2410 mL
10 mM 0.2120 mL 1.0602 mL 2.1205 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.30 mM); Clear solution

*All of the co-solvents are available by MCE.
References
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Product Name:
ML277
Cat. No.:
HY-12343
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