1401242-74-7
1401242-74-7
Chemical Structure
ML277
Synonym(s): CID-53347902
- CAS No.: 1401242-74-7
- Formula:C23H25N3O4S2
- Molecular Weight:471.59
IUPAC Name: (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide
InChIKey: OXQNLLVUVDAEHC-OAQYLSRUSA-N
SMILES: O=C([C@@H]1N(S(=O)(C2=CC=C(C)C=C2)=O)CCCC1)NC3=NC(C4=CC=C(OC)C=C4)=CS3
Biological Activity: ML277 (CID-53347902) is a potent and selective activator of K(v)7.1 (KCNQ1) potassium channel activator (EC50=270 nM), rescues function of pathophysiologically important mutant channel complexes in human induced pluripotent stem cell-derived cardiomyocytes[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ML277 | 98.46% | ML277 (CID-53347902) is a potent and selective activator of K(v)7.1 (KCNQ1) potassium channel activator (EC50=270 nM), rescues function of pathophysiologically important mutant channel complexes in human induced pluripotent stem cell-derived cardiomyocytes. | ||||||||||||||||||||
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References
- [1]. Eldstrom J, et al. ML277 regulates KCNQ1 single-channel amplitudes and kinetics, modified by voltage sensor state. J Gen Physiol. 2021 Dec 6;153(12):e202112969. [Content Brief]
- [2]. Mattmann ME, et al. Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator. Bioorg Med Chem Lett. 2012 Sep 15;22(18):5936-41. [Content Brief]
Keywords
