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Results for "

aminopeptidase activity

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Aminopeptidase (26) MetAP (8) Amino Acid Derivatives (1) Androgen Receptor (2) Angiotensin-converting Enzyme (ACE) (2) Antibiotic (2) Apoptosis (3) Bacterial (7) Biochemical Assay Reagents (2) Carboxypeptidase (1) Caspase (1) COX (1) Dipeptidyl Peptidase (2) DNA Methyltransferase (1) DNA/RNA Synthesis (2) Drug Derivative (1) Endogenous Metabolite (2) Enteropeptidase (2) Epoxide Hydrolase (1) ERK (2) Farnesyl Transferase (1) Fluorescent Dye (2) HDAC (1) IKK (1) Leukotriene Receptor (3) Lipase (1) MMP (2) mTOR (2) MyD88 (1) Neprilysin (3) NF-κB (3) NO Synthase (1) NOD-like Receptor (NLR) (1) Opioid Receptor (3) p38 MAPK (1) Parasite (4) Phosphatase (3) Phosphorylase (1) Potassium Channel (2) PPAR (1) Proteasome (1) Pyroptosis (1) Reference Standards (2) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (15) Cardiovascular Disease (3) Endocrinology (1) Infection (11) Inflammation/Immunology (11) Metabolic Disease (8) Neurological Disease (6)

By Targets:

Aminopeptidase (26)

MetAP (8)

Amino Acid Derivatives (1)

Androgen Receptor (2)

Angiotensin-converting Enzyme (ACE) (2)

Antibiotic (2)

Apoptosis (3)

Bacterial (7)

Biochemical Assay Reagents (2)

Carboxypeptidase (1)

Caspase (1)

COX (1)

Dipeptidyl Peptidase (2)

DNA Methyltransferase (1)

DNA/RNA Synthesis (2)

Drug Derivative (1)

Endogenous Metabolite (2)

Enteropeptidase (2)

Epoxide Hydrolase (1)

ERK (2)

Farnesyl Transferase (1)

Fluorescent Dye (2)

HDAC (1)

IKK (1)

Leukotriene Receptor (3)

Lipase (1)

MMP (2)

mTOR (2)

MyD88 (1)

Neprilysin (3)

NF-κB (3)

NO Synthase (1)

NOD-like Receptor (NLR) (1)

Opioid Receptor (3)

p38 MAPK (1)

Parasite (4)

Phosphatase (3)

Phosphorylase (1)

Potassium Channel (2)

PPAR (1)

Proteasome (1)

Pyroptosis (1)

Reference Standards (2)

Toll-like Receptor (TLR) (1)

By Research Areas:

Cancer (15)

Cardiovascular Disease (3)

Endocrinology (1)

Infection (11)

Inflammation/Immunology (11)

Metabolic Disease (8)

Neurological Disease (6)

Inhibitors & Agonists

Fluorescent Dyes

Peptides

Natural
Products

Targets Recommended: Aminopeptidase MetAP

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-113952

Actinonin 5+ Cited Publications (-)-Actinonin	Aminopeptidase Bacterial MMP Apoptosis Antibiotic	Infection Cancer
Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces. Actinonin inhibits aminopeptidase M, aminopeptidase N and leucine aminopeptidase. Actinonin is a potent reversible peptide deformylase (PDF) inhibitor with a K_i of 0.28 nM. Actinonin also inhibits MMP-1, MMP-3, MMP-8, MMP-9, and hmeprin α with K_i values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin is an apoptosis inducer. Actinonin has antiproliferative and antitumor activities .

HY-114336

Enocyanin 3 Publications Verification	Phosphatase	Inflammation/Immunology
Enocyanin is an anthocyanin extracted from grapes. Enocyanin shows inhibitory effect on the leucine aminopeptidase, acid phosphatase, γ-glutamyl transpeptidase and esterase activity .

HY-133125

ERAP1-IN-1 5 Publications Verification	Aminopeptidase	Inflammation/Immunology
ERAP1-IN-1 is an *endoplasmic reticulum aminopeptidase* 1 (ERAP1)** inhibitor. ERAP1-IN-1 competitively inhibits ERAP1 activity towards a nonamer peptide representative of physiological substrates .

HY-119244

Gly-Pro-pNA hydrochloride	Dipeptidyl Peptidase	Metabolic Disease
Gly-Pro-pNA hydrochloride is a chromogenic peptide substrate that can be cleaved by the circulating enzyme dipeptidyl peptidase IV (DPP IV). Gly-Pro-pNA hydrochloride is mainly used to detect the activity of aminopeptidases such as DPP IV. Gly-Pro-pNA hydrochloride can be investigated as an experimental antidiabetic agent .

HY-B1467

Domiphen bromide 1 Publications Verification	Potassium Channel Bacterial Parasite Phosphatase	Infection Inflammation/Immunology
Domiphen bromide is a cationic active quaternary ammonium salt and also an inhibitor of HERG channels (IC₅₀: 9 nM), aminopeptidase-like enzymes, Escherichia coli alkaline phosphatase, and α-chymotrypsin. Domiphen bromide has multiple activities such as antibacterial, antimalarial, and disinfectant properties, and it is also a synergist of Colistin (HY-113678). Domiphen bromide can be used as a chemical preservative and a cationic surfactant, and it can also be used in the research of bacterial infectious diseases such as pharyngitis, thrush, and oral ulcers .

HY-W345510

Opiorphin	Neprilysin	Neurological Disease
Opiorphin, an opioid peptide, is a potent enkephalin-inactivating zinc ectopeptidases in human inhibitor. Opiorphin inhibits two enkephalin-catabolizing ectoenzymes, human neutral ecto-endopeptidase, hNEP (EC 3.4.24.11) with an IC₅₀ value of 11 μM, and human ecto-aminopeptidase, hAP-N (EC 3.4.11.2). Opiorphin displays potent analgesic activity by activating endogenous opioid-dependent transmission .

HY-16710

GPDA 1 Publications Verification GPN; Glycylproline p-nitroanilide tosylate	Fluorescent Dye	Others
GPDA (GPN; Glycylproline p-nitroanilide tosylate) is a chromogenic substrate of prolyl dipeptidyl aminopeptidase. GPDA is used to detect the activity of prolyl dipeptidyl aminopeptidase in human serum .

HY-133016

M8891	MetAP	Cardiovascular Disease Cancer
M8891 is an orally active, reversible and brain penetrant *Methionine Aminopeptidase-2 (MetAP-2)* inhibitor with an IC₅₀ of 54 nM and a K_i of 4.33 nM. M8891 does not inhibit MetAP-1 (IC₅₀>10 µM) . M8891 inhibits growth of primary endothelial cells as well as tumor cells and demonstrates antiangiogenic and antitumoral activity .

HY-120868

TP-004 1 Publications Verification	MetAP	Metabolic Disease Cancer
TP-004 is a potent and reversible inhibitor of *methionine aminopeptidase* 2 (MetAP2), with an IC₅₀** of 6 nM against MetAP2. TP-004 is a chemical probe. TP-004 suppresses MetAP2 enzymatic activity, blocks N-terminal methionine cleavage, impairs protein maturation and stability, and thereby inhibits cell proliferation and angiogenesis. TP-004 can be used for the study of tumors and diseases associated with excessive angiogenesis .

HY-W027340

ARM1 1 Publications Verification 4BSA	Aminopeptidase Epoxide Hydrolase	Cancer
ARM1 (4BSA) is a potent *aminopeptidase* and epoxide hydrolase inhibitor. ARM1 shows aminopeptidase inhibitory activity with an IC₅₀ 7.61 µM and epoxide hydrolase inhibitory activity with an IC₅₀ 12.4 µM .

HY-14811

Beloranib ZGN-440; CKD-732 free base	MetAP NF-κB	Metabolic Disease
Beloranib (ZGN-440; CKD-732 free base) is a selective, irreversible inhibitor of methionine aminopeptidase MetAP2 that suppresses appetite and increases energy expenditure. Beloranib blocks the enzymatic cleavage of N-terminal methionine from nascent proteins by forming a covalent bond with MetAP2, thereby regulating fatty acid metabolism, adrenergic signaling, and hypothalamic NF-κB expression. Beloranib significantly reduces food intake, body weight, and fat accumulation, while improving glucose tolerance, insulin sensitivity, and lipid metabolism. Beloranib also elevates energy expenditure and fat oxidation levels, without affecting body temperature, spontaneous activity, or the inflammatory cytokine IL-1β. Beloranib can be used in research on obesity and hypothalamic obesity .

HY-122369

Histargin	Carboxypeptidase	Metabolic Disease
Histargin is a selective carboxypeptidase B inhibitor with an IC₅₀ of 17 μg/mL and a K_i of 30 μM. Histargin exerts competitive inhibition with substrate, with inhibitory activity abolished by metal cations. Histargin shows no significant inhibitory activity against carboxypeptidase A, aminopeptidase A, or aminopeptidase B .

HY-158006

SDX-7539	MetAP	Cancer
SDX-7539 is a selective inhibitor for Methionine aminopeptidase type 2 (MetAP2). SDX-7539 inhibits proliferarion of HUVECs with an IC₅₀ of 120 μM. SDX-7539 exhibits antitumor activity in NSCLC xenograft athymic nude mice .

HY-126564

Ebelactone A	Lipase MetAP	Others Inflammation/Immunology
Ebelactone A is a mycolic acid β-lactone, which exhibits inhibitory activity for esterase, lipase, fMet aminopeptidase (fMet AP) and PNBase, with IC₅₀s of 56, 3, 8 and 7.5 μM, respectively . Ebelactone A inhibits cutinase, exhibits plants protective potency against Erysiphe graminis .

HY-W097753

4-MDM 4-Methoxydiphenylmethane	Aminopeptidase	Others
4-MDM (4-Methoxydiphenylmethane) is an orally active anti-inflammatory compound that selectively enhances the Leukotriene A₄ Hydrolase (LTA₄H) aminopeptidase enzyme activity. 4-MDM reduces the neutrophil recruitment in the lung by enhancing the degradation of proline-glycine-proline by LTA₄H, thereby reducing inflammation, and does not affect the epoxy-hydrolase activity of LTA₄H. 4-MDM can be used for research on lung diseases .

HY-N2150

Psammaplin A	HDAC DNA Methyltransferase DNA/RNA Synthesis Bacterial Aminopeptidase Farnesyl Transferase PPAR Apoptosis	Infection Inflammation/Immunology Cancer
Psammaplin A is a marine metabolite. Psammaplin A is a selective HDAC1 (IC₅₀: 45 nM), DNA methyltransferases (IC₅₀: 18.6 nM) and aminopeptidase N (APN) (IC₅₀: 18 μM) inhibitor. Psammaplin A also inhibits DNA topoisomerase and farnesyl protein transferase. Psammaplin A is a PPARγ activator and induces apoptosis. Psammaplin A has antitumor and anti-inflammatory activities. Psammaplin A has antibacterial activity against Gram-positive bacteria and inhibits DNA synthesis and DNA gyrase activity. Psammaplin A inhibits angiogenesis .

HY-P2648

Suc-Ala-Ala-Pro-Leu-pNA N-Succinyl-AAPL-p-nitroanilide	Aminopeptidase	Endocrinology
Suc-Ala-Ala-Pro-Leu-pNA (N-Succinyl-AAPL-p-nitroanilide) is a tripeptidyl p-nitroanilide substrate that can be catalytically hydrolyzed by acyl amidase-like leucine aminopeptidase in seminal plasma. Amastatin (HY-129298) and Actinonin (HY-113952) exert potent inhibitory effects on this hydrolytic activity. Suc-Ala-Ala-Pro-Leu-pNA can be used for the research of diseases such as azoospermia .

HY-19876

PL37 Debio-0827	Opioid Receptor Aminopeptidase Neprilysin	Neurological Disease Metabolic Disease
PL37 (Debio-0827) is an orally active Enkephalinase dual inhibitor (dual inhibition refers to the simultaneous inhibition of Neutral Endopeptidase and Aminopeptidase N activities). PL37 exerts its anti-hyperalgesic effects by activating μ-opioid receptors (µ-opioid receptors), with an ED₅₀ value of 13.4 mg/kg for analgesic effects in mice. PL37 can be used to study diabetic neuropathic pain .

HY-14811A

Beloranib hemioxalate ZGN-440 hemioxalate; ZGN-433 hemioxalate; CDK732 hemioxalate	NF-κB MetAP	Metabolic Disease
Beloranib (ZGN-440; CKD-732 free base) hemioxalate is a selective, irreversible inhibitor of methionine aminopeptidase MetAP2 that suppresses appetite and increases energy expenditure. Beloranib hemioxalate blocks the enzymatic cleavage of N-terminal methionine from nascent proteins by forming a covalent bond with MetAP2, thereby regulating fatty acid metabolism, adrenergic signaling, and hypothalamic NF-κB expression. Beloranib hemioxalate significantly reduces food intake, body weight, and fat accumulation, while improving glucose tolerance, insulin sensitivity, and lipid metabolism. Beloranib hemioxalate also elevates energy expenditure and fat oxidation levels, without affecting body temperature, spontaneous activity, or the inflammatory cytokine IL-1β. Beloranib hemioxalate can be used in research on obesity and hypothalamic obesity .

HY-P4584

TRH-βNA	Biochemical Assay Reagents	Others
TRH-βNA is a substrate for determining the membrane TRH-deamidating enzyme (TRH-DE) activity and membrane pyroglutamyl aminopeptidase II (PPII) activity .

HY-W250725

H-GLU-AMC-OH	Fluorescent Dye	Neurological Disease
H-GLU-AMC-OH is an amino acid derivative that can be used as A fluorescent peptide substrate for the determination of aminopeptidase A enzyme activity .

HY-P4658

H-Val-Ala-pNA	Dipeptidyl Peptidase	Others
H-Val-Ala-pNA is a substrate for the dipeptide aminopeptidase (DPAPase) of Streptococcus bovis. H-Val-Ala-pNA can be used to measure the activity of the protease .

HY-P11334

Cyanostatin B	Aminopeptidase Phosphatase Angiotensin-converting Enzyme (ACE) DNA/RNA Synthesis	Cancer
Cyanostatin B, a cyanobacterial lipopeptide, is a leucine aminopeptidase M (LAP) inhibitor (IC₅₀ = 12 ng/mL). Cyanostatin B is a weak inhibitor of protein phosphatase (PP2A) and also exhibits weak inhibitory activity against angiotensin-converting enzyme (ACE), with an IC₅₀ value of 130 μg/mL. Cyanostatin B demonstrates both cytotoxic and genotoxic effects on human hepatocytes, although non-toxic to Artemia salina. Cyanostatin B inhibits the proliferation of HepG2 cells, induces DNA single-strand breaks, and causes genomic instability. .

HY-162920

QGC583	Aminopeptidase	Cardiovascular Disease
QGC583 is an effective selective Aminopeptidase A (APA) inhibitor with oral activity and blood-brain barrier permeability, boasting an IC₅₀ value of 4 nM. QGC583 can inhibit APA activity in the brain, kidneys, and heart of rats .

HY-P11642A

Sialorphin TFA	Enteropeptidase Aminopeptidase Opioid Receptor ERK mTOR Androgen Receptor	Inflammation/Immunology
Sialorphin TFA is a neutral endopeptidase (NEP) and aminopeptidase N (APN) inhibitor that responds to androgen signals. Sialorphin TFA blocks the degradation of endogenous opioid peptides and interacts with μ-, δ-, κ-opioid receptors. Sialorphin TFA regulates the ERK/mTOR signaling pathway by inducing cell cycle arrest, enhancing ERK1/2 activity, and reducing the phosphorylation levels of mTOR, 4E-BP1, p70S6K; accordingly, Sialorphin TFA exhibits antiproliferative activity against colorectal cancer, glioma and prostate cancer cells without cytotoxicity. In addition, Sialorphin TFA also produces antinociceptive responses, regulates sexual behavior, relaxes corpus cavernosum smooth muscle, and alleviates experimental colitis. Sialorphin TFA is also a copper (II) ion-binding ligand. Sialorphin TFA has been used in mechanistic studies related to cancer, pain management and inflammatory bowel disease .

HY-136614

H-Val-βNA L-Valine β-naphthylamide	Aminopeptidase	Others
H-Val-βNA (L-Valine β-naphthylamide) can be used as an aminopeptidase and a Valine arylamidase substrate .

HY-169596

Arphamenine A	Aminopeptidase	Cancer
Arphamenine A is an aminopeptidase B inhibitor found in Chromobacteriuin violaceum HMG361-CF4. Arphamenine A can inhibit the activity of aminopeptidase B, and can inhibit sarcoma 180 and invasive micropapillary carcinoma (IMC) cancer .

HY-172879

Aminopeptidase N inhibitor 2	Aminopeptidase	Cancer
Aminopeptidase N inhibitor 2 (Compound 2k) is an APN inhibitor (IC₅₀: 4.3 μM) and has antitumor activity.

HY-113952R

Actinonin (Standard) (-)-Actinonin (Standard)	Reference Standards Aminopeptidase Bacterial MMP Apoptosis Antibiotic	Infection Cancer
Actinonin (Standard) is the analytical standard of Actinonin. This product is intended for research and analytical applications. Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces. Actinonin inhibits aminopeptidase M, aminopeptidase N and leucine aminopeptidase. Actinonin is a potent reversible peptide deformylase (PDF) inhibitor with a Ki of 0.28 nM. Actinonin also inhibits MMP-1, MMP-3, MMP-8, MMP-9, and hmeprin α with Ki values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin is an apoptosis inducer. Actinonin has antiproliferative and antitumor activities[1][2][3][4][5].

HY-158410

PSA-IN-1	Aminopeptidase	Neurological Disease
PSA-IN-1 (compound 19) is a *puromycin sensitive aminopeptidase* (PSA) inhibitor with IC₅₀** at 7 nM. PSA-IN-1 has analgesic activity .

HY-143249

MtMetAP1-IN-1	Bacterial	Infection
MtMetAP1-IN-1 is an inhibitor of Mycobacterium tuberculosis (Mtb), targeting *methionine aminopeptidase* 1 (MetAP1*). MtMetAP1-IN-1 exerts antimycobacterial activity* .

HY-116476

Risotilide	Neprilysin	Others
Risotilide is an inhibitor of enkephalinase B, which has the ability to inhibit enkephalinase B activity (IC₅₀ value is 0.35 microM), and can also effectively inhibit enkephalinase A (IC₅₀ = 0.02 microM) and aminopeptidase activity (IC₅₀ = 13 microM), and can be regarded as a complete inhibitor of enkephalin biodegradation.

HY-125564

Acetyltrialanine	Aminopeptidase	Others
Acetyltrialanine is a peptide containing three amino acid residues in which the N-terminal amino acid is acetylated and used as a substrate for Nα-acetyl alanine aminopeptidase in order to study the activity and properties of the enzyme. Acetyltrialanine can be used in the study of protein degradation and N-terminal regulation .

HY-125341

Microginin 527	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Microginin 527 is a linear cyanobacterial peptide with potent angiotensin-converting enzyme (ACE) inhibitory activity. Microginin 527 also exhibits inhibitory effects on protein phosphatases and leucine aminopeptidase. With an IC50 value of 31 μM, Microginin 527 is the most active component in this class of compounds .

HY-156960

JNJ-40929837	Aminopeptidase Leukotriene Receptor	Inflammation/Immunology
JNJ-40929837 is a selective and orally active LTA₄H (leukotriene A₄ hydrolase) inhibitor. JNJ-40929837 effectively inhibits *aminopeptidase* activity and causes serum accumulation of Pro-Gly-Pro. JNJ-40929837 can be used in asthma research .

HY-156960A

JNJ-40929837 succinate	Aminopeptidase Leukotriene Receptor	Inflammation/Immunology
JNJ-40929837 succinate is a selective and orally active LTA₄H (leukotriene A₄ hydrolase) inhibitor. JNJ-40929837 succinate effectively inhibits *aminopeptidase* activity and causes serum accumulation of Pro-Gly-Pro. JNJ-40929837 succinate can be used in asthma research .

HY-129407

AAF-CMK TFA Ala-ala-phe-chloromethylketone tfa; N-Ala-Ala-Phe-CMK; Tripeptidyl Peptidase inhibitor II	Proteasome	Infection
AAF-CMK TFA (Ala-ala-phe-chloromethylketone tfa; N-Ala-Ala-Phe-CMK) is a subtilisin-type serine peptidase that removes tripeptides from the free NH2 termini of oligopeptides. AAF-CMK TFA is an irreversible inhibitor of TPPII and is typically used at concentrations of 10-100 μM. It does not significantly interfere with the chymotrypsin-like activity of the proteasome. AAF-CMK also inhibits bleomycin hydrolase and puromycin-sensitive aminopeptidase when used at a concentration of 50 μM.

HY-B1467R

Domiphen bromide (Standard)	Reference Standards Potassium Channel Bacterial Parasite Phosphorylase	Infection Inflammation/Immunology
Domiphen bromide (Standard) is the analytical standard of Domiphen bromide (HY-B1467). This product is intended for research and analytical applications. Domiphen bromide is a cationic active quaternary ammonium salt and also an inhibitor of HERG channels (IC₅₀: 9 nM), aminopeptidase-like enzymes, Escherichia coli alkaline phosphatase, and α-chymotrypsin. Domiphen bromide has multiple activities such as antibacterial, antimalarial, and disinfectant properties, and it is also a synergist of Colistin (HY-113678). Domiphen bromide can be used as a chemical preservative and a cationic surfactant, and it can also be used in the research of bacterial infectious diseases such as pharyngitis, thrush, and oral ulcers.

HY-138232

Lys-psi(CH2NH)-Trp(Nps)-OMe LTNAM	Aminopeptidase	Neurological Disease
Lys-psi(CH2NH)-Trp(Nps)-OMe is a lysine-tryptophan (Nps) pseudodipeptide analog. It is obtained by replacing the peptide bond in the Lys-Trp(Nps) molecule with an aminomethylene bond and has analgesic activity. Lys-psi(CH2NH)-Trp(Nps)-OMe induces a dose-dependent and naloxone-reversible analgesia after intracerebroventricular administration in mice, and its analgesic effect lasts longer than that of the original compound. It protects methionine enkephalin from degradation in rat striatal slices and binds to low-dose opioid peptides to produce analgesia. Lys-psi(CH2NH)-Trp(Nps)-OMe effectively inhibits brain aminopeptidase activity both in vitro and in vivo. The enhanced resistance of this pseudodipeptide to proteolysis may explain its prolonged analgesic activity.

HY-181437

Antiparasitic agent-40	Parasite Aminopeptidase	Infection
Antiparasitic agent-40 (compound 4.3) is a 4-thiazolidinone-based antileishmaniasis inhibitor. Antiparasitic agent-40 exhibits significant inhibitory activity against methionine aminopeptidase .

HY-137842

L-Alanine-2-naphthylamide Alanine β-naphthylamide	Aminopeptidase Biochemical Assay Reagents	Others
L-Alanine-2-naphthylamide (Alanine β-naphthylamide) is an *Aminopeptidase* (E.C. 3.4.11.) substrate and detection reagent. L-Alanine-2-naphthylamide detects the functional activity of aminopeptidase in the intestine of larval whitefish (Coregonus lavaretus). L-Alanine-2-naphthylamide serves as an initiator in the N-carboxyanhydride (NCA) method for synthesizing poly (β-benzyl-L-aspartate) polymers with a terminal 2-naphthyl energy donor group .

HY-182419

A-849519	MetAP	Cancer
A-849519 is a reversible methionine aminopeptidase-2 (MetAP-2) inhibitor with an IC₅₀ of 19 nM. A-849519 binds to the active site of the Mn ²⁺ form of human MetAP-2, where the oxygen atom of one acidic functional group interacts with the manganese ion, and another heteroatom binds to the water molecule above the two manganese ions, thereby functionally inhibiting enzyme activity. A-849519 inhibits the methionine processing activity of MetAP-2 as well as the proliferation of fibrosarcoma cells. A-849519 can be used in studies related to fibrosarcoma .

HY-W612175

H-Ala-pNA	Leukotriene Receptor	Others
H-Ala-pNA is an L-amino acid p-nitroaniline (pNA) derivative and a specific substrate for leukotriene A4 hydrolase. The D-enantiomer of H-Ala-pNA shows no activity toward leukotriene A4 hydrolase. H-Ala-pNA can be catalytically hydrolyzed by leukotriene A4 hydrolase, and the p-nitroaniline produced during the reaction is monitored spectrophotometrically at 405 nm to enable quantitative detection of enzyme activity. H-Ala-pNA is used to evaluate the potency of inhibitors targeting the amidase activity of leukotriene A4 hydrolase .

HY-181674

ZHO-197	Aminopeptidase Bacterial	Infection
ZHO-197 is a dual bacterial peptide deformylase and methionine aminopeptidase inhibitor with antibacterial activity. ZHO-197 exhibits an Escherichia coli peptide deformylase IC₅₀ of 0.021 μM and a human peptide deformylase IC₅₀ of 3.289 μM. ZHO-197 displays broad-spectrum antibacterial activity against gram-positive and gram-negative bacterial strains. ZHO-197 can be used for the research of bacterial infection .

HY-181644

NS-181	MetAP	Infection
NS-181 is an orally active MetAP2 inhibitor and antiamebic agent with oral effectiveness.NS-181 functionally inhibits methionine aminopeptidase 2, a protein critical for Entamoeba histolytica proliferation. NS-181 exerts antiamebic activity against Entamoeba histolytica, leading to resolution of amebic liver abscess. NS-181 can be used for the research of amebiasis .

HY-103294

R892	Endogenous Metabolite	Others
R892 is a selective and efficient bradyK_inin B1 receptor antagonist with significant antagonistic activity. The pA2 values of R892 in human and rabbit B1 receptors are 8.8 and 8.6 respectively, indicating its strong anti-activity at these receptors. R892 exhibits selectivity with ID50 values of 2.8 nM and >600 nM for B1 and B2 receptors, respectively, and has no endogenous agonist activity. R892 is resistant to aminopeptidase and kininase II (ACE) degradation and exhibits metabolic stability .

HY-181266

Antimalarial agent 55	Parasite Aminopeptidase	Infection
Antimalarial agent 55 is an orally potent inhibitor of PfA-M1 and PfA-M17 aminopeptidases from Plasmodium falciparum, with K_i values of 27 nM and 81 nM, respectively. Antimalarial agent 55 exhibits potent nanomolar activity against homologous enzymes from Plasmodium vivax and Plasmodium berghei, with K_i values of 2 nM, 4 nM, 190 nM and 18 nM for Pv-M1, Pb-M1, Pv-M17 and Pb-M17, respectively. Antimalarial agent 55 possesses significant antiplasmodial activity, as well as cross-species inhibitory capacity and broad-spectrum activity that is unaffected by existing drug resistance mechanisms. Antimalarial agent 55 can be used in malaria research .

HY-183739

CQ31	Pyroptosis Caspase	Cancer
CQ31 is a PEPD and XPNPEP1 inhibitor, with an IC₅₀ of 0.67 μM against PEPD and an IC₅₀ of 122 μM against XPNPEP1. CQ31 inhibits the M24B aminopeptidase activity of PEPD and XPNPEP1. CQ31 induces the accumulation of Xaa-Pro-containing peptides, mildly inhibits DPP8/9, and triggers CASP1-dependent pyroptosis via activation of the CARD8 inflammasome and caspase-1. CQ31 can be used in research related to cancers such as acute myeloid leukemia .

HY-N19847

LYRM03	Drug Derivative Aminopeptidase Endogenous Metabolite Toll-like Receptor (TLR) MyD88 NOD-like Receptor (NLR) NF-κB p38 MAPK IKK NO Synthase COX	Inflammation/Immunology Cancer
LYRM03 is a derivative of Ubenimex (HY-B0134) and a Aminopeptidase N inhibitor. LYRM03 is isolated from Streptomyces HCCB10043. LYRM03 inhibits TLR4, MyD88, NLRP3, ASC, NF-κB and p38 MAPK, stabilizes IκB, and suppresses LPS-induced expression of iNOS and COX-2. LYRM03 reduces the levels of inflammatory cytokines and oxidative stress markers, and alleviates pulmonary edema. LYRM03 exhibits anticancer activity against breast cancer. LYRM03 has anti-inflammatory activity. LYRM03 can be used in the research of acute lung injury and breast cancer .

HY-183267

ERAP1-IN-4	Aminopeptidase	Cancer
ERAP1-IN-4 is an orally acvtive *endoplasmic reticulum aminopeptidase* 1 (ERAP1*) inhibitor with a pIC₅₀ of 7.9 and an LLE of 5.3. ERAP1-IN-4 inhibits hydrolysis of peptide substrates by ERAP1, with high activity* against Allotype1 and Allotype2. ERAP1-IN-4 reduced efficacy against other allotypes, and modulates ERAP1-mediated peptide processing to inhibit antigenic epitope presentation. ERAP1-IN-4 can be used for the research of cancer^[1].

Cat. No.	Product Name	Type