H-Gly-D-Ala-OH 

H-Gly-D-Ala-OH is a dipeptide containing D-amino acid. H-Gly-D-Ala-OH can be specifically hydrolyzed by renal dipeptidase, which acts on peptide segments with a D-amino acid at the carboxyl terminus. H-Gly-D-Ala-OH enables highly specific detection of renal dipeptidase activity without interference from other serum or urine aminopeptidases. When used in combination with low-dose Sodium nitrite (HY-N11218), H-Gly-D-Ala-OH inhibits the initial spore growth of Clostridium botulinum in pork homogenate, whereas it has no such effect on its own. H-Gly-D-Ala-OH can be used in research related to chronic renal failure, diabetes mellitus and botulism^[1][2].

H-Gly-D-Ala-OH (150 mM; 30 min) acts as a highly specific substrate for purified swine renal dipeptidase, supporting precise measurement of the enzyme's activity with minimal interference from aminopeptidase activity^[1].
H-Gly-D-Ala-OH (0.26% (w/v); 56 days), when used in combination with 60 ppm sodium nitrite, potently inhibits outgrowth of mixed type A and type B Clostridium botulinum spores in minced pork slurry, resulting in an average 27 days for growth to occur, but shows no inhibitory activity when used alone^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

146.15

C₅H₁₀N₂O₃

691-81-6

N([C@@H](C(O)=O)C)C(CN)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Fukumura Y, et al. Behaviour of urinary dipeptidase in patients with chronic renal failure. Ann Clin Biochem. 1999;36 ( Pt 2):221-225.

  [2]. Paquet A, Rayman K. Some N-acyl-D-amino acid derivatives having antibotulinal properties. Canadian journal of microbiology. 1987 Jul 1;33(7):577-82.