H-Gly-D-Ala-OH
H-Gly-D-Ala-OH is a dipeptide containing D-amino acid. H-Gly-D-Ala-OH can be specifically hydrolyzed by renal dipeptidase, which acts on peptide segments with a D-amino acid at the carboxyl terminus. H-Gly-D-Ala-OH enables highly specific detection of renal dipeptidase activity without interference from other serum or urine aminopeptidases. When used in combination with low-dose Sodium nitrite (HY-N11218), H-Gly-D-Ala-OH inhibits the initial spore growth of Clostridium botulinum in pork homogenate, whereas it has no such effect on its own. H-Gly-D-Ala-OH can be used in research related to chronic renal failure, diabetes mellitus and botulism.
For research use only. We do not sell to patients.
- CAS No.: 691-81-6
- Formula: C5H10N2O3
- Molecular Weight:146.15
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
H-Gly-D-Ala-OH (150 mM; 30 min) acts as a highly specific substrate for purified swine renal dipeptidase, supporting precise measurement of the enzyme's activity with minimal interference from aminopeptidase activity[1].
H-Gly-D-Ala-OH (0.26% (w/v); 56 days), when used in combination with 60 ppm sodium nitrite, potently inhibits outgrowth of mixed type A and type B Clostridium botulinum spores in minced pork slurry, resulting in an average 27 days for growth to occur, but shows no inhibitory activity when used alone[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 691-81-6
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Molecular Weight 146.15
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Formula C5H10N2O3
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SMILES
N([C@@H](C(O)=O)C)C(CN)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)