ZHO-197
ZHO-197 is a dual bacterial peptide deformylase and methionine aminopeptidase inhibitor with antibacterial activity. ZHO-197 exhibits an Escherichia coli peptide deformylase IC50 of 0.021 μM and a human peptide deformylase IC50 of 3.289 μM. ZHO-197 displays broad-spectrum antibacterial activity against gram-positive and gram-negative bacterial strains. ZHO-197 can be used for the research of bacterial infection.
For research use only. We do not sell to patients.
- Formula: C19H35N3O5
- Molecular Weight:385.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
ZHO-197 (0.0033-10 μM; 3 h) potently inhibits recombinant Escherichia coli peptide deformylase with an IC50 of 0.021 ± 0.003 μM and shows selective inhibition for bacterial over human PDF[1].
ZHO-197 (0-256 μg/mL; overnight) exhibits antibacterial activity against gram-positive and gram-negative bacterial strains, with MIC values of 32, 2, 128, 4, and 2 μg/mL against Escherichia coli BW25113, E. coli ΔtolC, E. coli DSM30083, Staphylococcus aureus DSM20231, and Bacillus subtilis 168, respectively, and an MIC90 of 1.87 μg/mL against Mycobacterium tuberculosis Erdman[1].
ZHO-197 (30-300 μM; 72 h) shows no cytotoxicity against human peripheral blood mononuclear cells[1].
ZHO-197 (64 μg/mL; overnight) acts as a dual inhibitor, effectively inhibiting peptide deformylase and methionine aminopeptidase in intact Bacillus subtilis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 385.50
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Formula C19H35N3O5
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SMILES
O=CN(O)C[C@@H](CCCCC)C(N[C@@H](C(C)C)C(N1CCC[C@H]1CO)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ZHO-197 Related Classifications
HY-181674 Related Classifications
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- ZHO-197
- ZHO197
- ZHO 197
- Aminopeptidase
- Bacterial
- gram-positive bacterial strains
- Escherichia coli
- bacterial infection
- human peripheral blood mononuclear cells
- gram-negative bacterial strains
- tuberculosis
- Staphylococcus aureus
- Mycobacterium tuberculosis
- methionine aminopeptidase
- peptide deformylase
- Inhibitor
- inhibitor
- inhibit