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Cat. No.: HY-162920

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QGC583

QGC583 is an effective selective Aminopeptidase A (APA) inhibitor with oral activity and blood-brain barrier permeability, boasting an IC₅₀ value of 4 nM. QGC583 can inhibit APA activity in the brain, kidneys, and heart of rats.

For research use only. We do not sell to patients.

CAS No.: 2417001-25-1
Formula: C₁₃H₂₀NO₅P
Molecular Weight:301.28

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

QGC583 Chemical Structure

CAS No.: 2417001-25-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

IC50: 4 nM (APA)^[1].

All Aminopeptidase Isoforms :

CD13
LTA4H

In Vivo

QGC583 (2 mg/kg; i.v.; single dose) reduces APA activity in the heart, kidneys, and brain of rats by 78%, 66%, and 71% respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2417001-25-1
Molecular Weight 301.28
Formula C₁₃H₂₀NO₅P
SMILES

O=P([C@@H](N)CCC(O)=O)(O)CCC1=C(OC)C=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Balavoine F, et al. Rational design, synthesis and pharmacological characterization of novel aminopeptidase A inhibitors[J]. Bioorganic & Medicinal Chemistry Letters, 2024, 113: 129940. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Purity & Documentation
References

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QGC583

All Aminopeptidase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

QGC583 Related Classifications

HY-162920 Related Classifications