Histargin
Histargin is a selective carboxypeptidase B inhibitor with an IC50 of 17 μg/mL and a Ki of 30 μM. Histargin exerts competitive inhibition with substrate, with inhibitory activity abolished by metal cations. Histargin shows no significant inhibitory activity against carboxypeptidase A, aminopeptidase A, or aminopeptidase B.
For research use only. We do not sell to patients.
- CAS No.: 93361-66-1
- Formula: C14H25N7O4
- Molecular Weight:355.39
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
carboxypeptidase B 17 μg/mL (IC50) |
carboxypeptidase B 30 μM (Ki) |
Histargin monohydrate (30 min) potently and competitively inhibits purified bovine carboxypeptidase B with an IC50 of 17 μg/mL and a Ki of 3.2 × 10-5 M, and this inhibitory activity is dependent on metal chelation, being blocked by specific divalent metal cations[1].
Histargin does not inhibit purified carboxypeptidase A, aminopeptidase A (IC50 >100 μg/mL)[1].
Histargin lacks antimicrobial activity at 100 μg/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 93361-66-1
-
Molecular Weight 355.39
-
Formula C14H25N7O4
-
SMILES
N=C(N)NCCC[C@@H](C(O)=O)NCCN[C@H](C(O)=O)CC1=CN=CN1
-
Structure Classification
-
Initial Source
Streptomyces roseoviridis
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz