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MtMetAP1-IN-1 

Cat. No.: HY-143249
Handling Instructions

MtMetAP1-IN-1 is an inhibitor of Mycobacterium tuberculosis (Mtb), targeting methionine aminopeptidase 1 (MetAP1). MtMetAP1-IN-1 exerts antimycobacterial activity.

For research use only. We do not sell to patients.

MtMetAP1-IN-1 Chemical Structure

MtMetAP1-IN-1 Chemical Structure

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Description

MtMetAP1-IN-1 is an inhibitor of Mycobacterium tuberculosis (Mtb), targeting methionine aminopeptidase 1 (MetAP1). MtMetAP1-IN-1 exerts antimycobacterial activity[1].

IC50 & Target

methionine aminopeptidase 1 (MetAP1)[1]

In Vitro

MetAP1 is known to work in the presence of various divalent cations, is considered to acts function with a most probable cofactor, iron (Fe2+)[1].
MtMetAP1-IN-1 (compound 12) (12.5 μM; ) inhibits MtMetAP1 under different metals catalytic effect with residual activity RA (%) of 51% (Co2+), 21% (Ni2+), 33% (Fe2+)[1].
MtMetAP1-IN-1 has a preference towards Ni2+, inhibits MtMetAP1 with an IC50 value of with 0.7 μM [1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

404.24

Formula

C15H10BrN5O2S

SMILES

O=C(C1=NC=CN=C1NC(C2=C(C=CC=C2)Br)=O)NC3=NC=CS3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Product Name:
MtMetAP1-IN-1
Cat. No.:
HY-143249
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