Co | MedChemExpress (MCE) Life Science Reagents

By Targets:	ADC Cytotoxin (2) ADC Linker (5) Antibiotic (2) Apelin Receptor (APJ) (1) Apoptosis (6) Autophagy (2) Bacterial (10) Biochemical Assay Reagents (133) Calcium Channel (1) Cathepsin (1) CD28 (2) Cholinesterase (ChE) (1) COX (2) CTLA-4 (2) Cytochrome P450 (3) DNA Stain (1) DNA-PK (2) DNA/RNA Synthesis (1) Drug Metabolite (1) Drug-Linker Conjugates for ADC (4) E3 Ligase Ligand-Linker Conjugates (4) EGFR (2) Endogenous Metabolite (30) Epigenetic Reader Domain (2) FAK (1) FKBP (1) FLAP (1) Fluorescent Dye (13) Fungal (1) GCGR (4) GLP Receptor (4) GlyT (2) Guanylate Cyclase (1) Histone Methyltransferase (4) HIV (1) HSP (5) iGluR (15) Indoleamine 2,3-Dioxygenase (IDO) (1) Influenza Virus (1) Interleukin Related (1) Isotope-Labeled Compounds (9) LAG-3 (1) Ligands for E3 Ligase (8) Liposome (5) LXR (1) Molecular Glues (1) Monoamine Oxidase (1) nAChR (1) NF-κB (1) Nucleoside Antimetabolite/Analog (2) Orexin Receptor (OX Receptor) (1) Orthopoxvirus (1) Paraptosis (1) PD-1/PD-L1 (3) PPAR (3) PROTAC Linkers (14) PROTAC-Linker Conjugates for PAC (1) PROTACs (2) Protease Activated Receptor (PAR) (1) Reactive Oxygen Species (3) SARS-CoV (1) SGLT (4) Small Interfering RNA (siRNA) (4) Sodium Channel (3) Somatostatin Receptor (3) STAT (1) Target Protein Ligand-Linker Conjugates (2) Thrombin (1) Thyroid Hormone Receptor (1) TNF Receptor (1) TRP Channel (2) VEGFR (1)
By Research Areas:	Cancer (93) Cardiovascular Disease (6) Endocrinology (3) Infection (19) Inflammation/Immunology (28) Metabolic Disease (26) Neurological Disease (26)
Click Chemistry:	ADC Synthesis (1) PROTAC Synthesis (8) Azide (10) Alkynes (8)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-108504

Co 102862 V 102862	Sodium Channel	Neurological Disease
Co 102862 (V 102862) is a potent, broad-spectrum, state-dependent Na ⁺ channel blocker. Co 102862 is also an orally active anticonvulsant .

HY-130012

CO23	Thyroid Hormone Receptor	Metabolic Disease Endocrinology
CO23 is a selective thyroid hormone receptor (TR) α agonist and used for growth and development regulation. CO23 was able to be transported through the blood-brain barrier .

HY-141795

Posovolone Co 134444	Others	Neurological Disease
Posovolone (Co 134444) is an orally active, neuroactive steroid. Posovolone has anticonvulsant and anxiolytic-like activity as well as ataxic effects .

HY-107706

Co 101244 hydrochloride

PD 174494 hydrochloride
iGluR Neurological Disease

Co 101244 (PD 174494) hydrochloride is a NR2B-containing NMDA receptor antagonist .

Co 101244 hydrochloride PD 174494 hydrochloride	iGluR	Neurological Disease
Co 101244 (PD 174494) hydrochloride is a NR2B-containing NMDA receptor antagonist .

HY-144368

CO delivery molecule 1	Others	Inflammation/Immunology
CO delivery molecule 1 (compound 4) localizes to the endoplasmic reticulum, mitochondria, and lysosomes. Subcellular localization of CO delivery molecule 1 results in CO-induced toxicity effects. Anti-inflammatory effects of CO delivery molecule 1, as measured by TNF-α suppression, occur at the nanomolar level in the absence of CO release, and are enhanced with visible-light-induced CO release .

HY-15729

Rociletinib 10+ Cited Publications Co-1686; AVL-301; CNX-419	EGFR	Cancer
Rociletinib (CO-1686) is an orally delivered kinase inhibitor that specifically targets the mutant forms of EGFR including T790M, and the K_i values for EGFRL858R/T790M and EGFRWT are 21.5 nM and 303.3 nM, respectively.

HY-W250116

Co(III) protoporphyrin IX chloride

Protoporphyrin IX Cobaltic chloride
Biochemical Assay Reagents Others

Co(III) Protoporphyrin IX chloride (CoPP) is an effective HO-1inducer.

Co(III) protoporphyrin IX chloride Protoporphyrin IX Cobaltic chloride	Biochemical Assay Reagents	Others
Co(III) Protoporphyrin IX chloride (CoPP) is an effective HO-1inducer.

HY-134608

Cobalt protoporphyrin IX Co-PPIX	Reactive Oxygen Species Influenza Virus	Infection
Cobalt protoporphyrin IX (Co-PPIX) is a potent and specific heme oxygenase-1 (HO-1) inducer. Cobalt protoporphyrin IX exhibits broad-spectrum antiviral activities against Influenza A virus (IAV) .

HY-15729A

Rociletinib hydrobromide 10+ Cited Publications Co-1686 hydrobromide; AVL-301 hydrobromide; CNX-419 hydrobromide	EGFR	Cancer
Rociletinib hydrobromide (CO-1686 hydrobromide) is an orally delivered kinase inhibitor that specifically targets the mutant forms of EGFR including T790M, and the K_i values for EGFRL858R/T790M and EGFRWT are 21.5 nM and 303.3 nM, respectively.

HY-W033577

Tricarbonyldichlororuthenium(II) dimer CoRM-2	Others	Inflammation/Immunology
Tricarbonyldichlororuthenium(II) dimer is a pharmacological donor of CO releasing. CO releases from Tricarbonyldichlororuthenium(II) dimer prevents gastric mucosal oxidative damage induced by ischemia/reperfusion (I/R) improving gastric blood flow (GBF), decreasing DNA oxidation and inflammatory response on systemic level .

HY-13538

Gemcitabine elaidate 2 Publications Verification CP-4126; Co-101; Gemcitabine 5'-elaidate	Nucleoside Antimetabolite/Analog Autophagy Apoptosis	Cancer
Gemcitabine elaidate (CP-4126) is lipophilic pro-agent of Gemcitabine. Gemcitabine elaidate is converted to Gemcitabine by esterases in order to be phosphorylated. Gemcitabine elaidate exhibits anti-tumor activity .

HY-13538A

Gemcitabine elaidate hydrochloride 2 Publications Verification CP-4126 hydrochloride; Co-101 hydrochloride; Gemcitabine 5'-elaidate hydrochloride	Nucleoside Antimetabolite/Analog Autophagy Apoptosis	Cancer
Gemcitabine elaidate (CP-4126) hydrochloride is lipophilic pro-agent of Gemcitabine. Gemcitabine elaidate hydrochloride is converted to Gemcitabine by esterases in order to be phosphorylated. Gemcitabine elaidate hydrochloride exhibits anti-tumor activity .

HY-P1212

Cortistatin 14, human, rat CST-14, human, rat	Somatostatin Receptor	Neurological Disease
Cortistatin 14, human, rat (CST-14, human, rat), a neuropeptide with neuronal depressant and sleep modulating properties, can bind to all five cloned somatostatin receptors (SSTRs) and ghrelin receptor to exert its biological activities and co-exists with GABA within the cortex and hippocampus .

HY-109804

CORM-401 1 Publications Verification	Reactive Oxygen Species	Inflammation/Immunology
CORM-401 is an oxidant-sensitive CO-releasing molecule. CORM-401 induces NO increase in the regulation of endothelial calcium signalling. CORM-401 reduces TNF-α/CHX and H2O2-induced ROS production. CORM-401 uncouples mitochondrial respiration and inhibits glycolysis .

HY-147692

COX-2-IN-14	COX	Inflammation/Immunology
COX-2-IN-14 (compound 2a) is a potent and selective COX-2 (cyclooxygenase-2) inhibitor. COX-2-IN-14 shows effective binding at the active site of COX-2 co-crystal. COX-2-IN-14 exhibits a high level of in vivo anti-inflammatory activity, reducing ear edema and myeloperoxidase (MPO) activity in mice .

HY-Y1887

Cottonseed oil	Biochemical Assay Reagents	Others
Cottonseed oil is a cooking oil extracted from the seeds of cotton plants and has been generally considered the most insecticidal of vegetable oils.

HY-Y1888

Corn oil

55+ Cited Publications

Biochemical Assay Reagents Others

Corn oil, extracted from the germ of corn, can be used as a carrier for agent molecules.

Corn oil 55+ Cited Publications	Biochemical Assay Reagents	Others
Corn oil, extracted from the germ of corn, can be used as a carrier for agent molecules.

HY-N11684

Cocoa butter	Biochemical Assay Reagents	Others
Cocoa butter can be used as an excipient, such as lubricants, suppository bases. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs .

HY-W392209A

Copovidone	Biochemical Assay Reagents	Others
Copovidone can be used as an excipient, such as Film formers, adhesives, etc. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs .

HY-141808

AZD-CO-Ph-PEG4-Ph-CO-AZD

Others Cancer

AZD-CO-Ph-PEG4-Ph-CO-AZD is a bis-β-lactam linker can be used for antibody-siRNA conjugate synthesis .

AZD-CO-Ph-PEG4-Ph-CO-AZD	Others	Cancer
AZD-CO-Ph-PEG4-Ph-CO-AZD is a bis-β-lactam linker can be used for antibody-siRNA conjugate synthesis .

HY-160077

Pomalidomide-CO-C5-azide	Ligands for E3 Ligase	Cancer
Pomalidomide-CO-C5-azide (Compound PA) is a ligand for E3 ligase bearing a bioorthogonal group azide. Pomalidomide-CO-C5-azide can be used to synthesize PROTACs with anticancer activity .

HY-108369

Azido-PEG1-CH2CO2H	PROTAC Linkers	Cancer
Azido-PEG1-CH2CO2H is a PROTAC linker, which refers to the alkyl/ether composition. Azido-PEG1-CH2CO2H can be used in the synthesis of PROTAC BRD4 Degrader-1 . Azido-PEG1-CH2CO2H is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-P2229

Ilatreotide SDZ Co 611	Somatostatin Receptor	Cancer
Ilatreotide (SDZ CO61), glycated somatostatin derivative, is a highly potent glycated analog of somatostatin with improved oral activity. Ilatreotide can suppress the fasting level and postprandial release of several gastrointestinal and pancreatic hormones. Ilatreotide can be used for the research of gastroenteropancreatic tumors .

HY-140747

BnO-PEG1-CH2CO2tBu

PROTAC Linkers Cancer

BnO-PEG1-CH2CO2tBu is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

BnO-PEG1-CH2CO2tBu	PROTAC Linkers	Cancer
BnO-PEG1-CH2CO2tBu is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-130194

Azido-PEG5-CH2CO2H	ADC Linker PROTAC Linkers	Cancer
Azido-PEG5-CH2CO2H is a cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG5-CH2CO2H is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG5-CH2CO2H is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-145767A

SN-38-CO-DMEDA TFA

Others Others

SN-38-CO-DMEDA TFA is the intermediate product for synthesizing antibody-conjugated drug LND1035 .

SN-38-CO-DMEDA TFA	Others	Others
SN-38-CO-DMEDA TFA is the intermediate product for synthesizing antibody-conjugated drug LND1035 .

HY-140766

Azido-PEG5-CH2CO2-NHS	PROTAC Linkers	Cancer
Azido-PEG5-CH2CO2-NHS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG5-CH2CO2-NHS is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-140763

Azido-PEG1-CH2CO2-NHS	PROTAC Linkers	Cancer
Azido-PEG1-CH2CO2-NHS is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG1-CH2CO2-NHS is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-140853

Azido-PEG3-CH2CO2Me	PROTAC Linkers	Cancer
Azido-PEG3-CH2CO2Me is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG3-CH2CO2Me is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-138350

Azido-PEG10-CH2CO2-NHS	PROTAC Linkers	Cancer
Azido-PEG10-CH2CO2-NHS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG10-CH2CO2-NHS is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-145755

Benzyl-piperazine-CO-benzothiazole-4-methylpiperidine

Others Others

Benzyl-piperazine-CO-benzothiazole-4-methylpiperidine alters the lifespan of a eukaryotic organism .
HY-140416

Boc-Aminooxy-PEG4-CH2CO2H

PROTAC Linkers Cancer

Boc-Aminooxy-PEG4-CH2CO2H is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
HY-140191

Amino-PEG4-(CH2)3CO2H

PROTAC Linkers Cancer

Amino-PEG4-(CH2)3CO2H is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

Benzyl-piperazine-CO-benzothiazole-4-methylpiperidine	Others	Others
Benzyl-piperazine-CO-benzothiazole-4-methylpiperidine alters the lifespan of a eukaryotic organism .

Boc-Aminooxy-PEG4-CH2CO2H	PROTAC Linkers	Cancer
Boc-Aminooxy-PEG4-CH2CO2H is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

Amino-PEG4-(CH2)3CO2H	PROTAC Linkers	Cancer
Amino-PEG4-(CH2)3CO2H is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-130693

Azido-PEG5-CH2CO2-PFP	PROTAC Linkers	Cancer
Azido-PEG5-CH2CO2-PFP is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs . Azido-PEG5-CH2CO2-PFP is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-139345

(S,R,S)-AHPC-CO-C9-acid VH032-NH-Co-C9-acid	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-CO-C9-acid is an E3 ligase ligand-linker conjugate that can be connected to the ligand for protein to form PROTACs.

HY-133544

Mal-CO-PEG5-NHS ester

ADC Linker Cancer

Mal-CO-PEG5- NHS ester is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Mal-CO-PEG5-NHS ester	ADC Linker	Cancer
Mal-CO-PEG5- NHS ester is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-RS08757

MT-CO1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MT-CO1 Human Pre-designed siRNA Set A contains three designed siRNAs for MT-CO1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MT-CO1 Human Pre-designed siRNA Set A MT-CO1 Human Pre-designed siRNA Set A

HY-RS08758

MT-CO2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MT-CO2 Human Pre-designed siRNA Set A contains three designed siRNAs for MT-CO2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MT-CO2 Human Pre-designed siRNA Set A MT-CO2 Human Pre-designed siRNA Set A

HY-RS08759

MT-CO3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MT-CO3 Human Pre-designed siRNA Set A contains three designed siRNAs for MT-CO3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MT-CO3 Human Pre-designed siRNA Set A MT-CO3 Human Pre-designed siRNA Set A

HY-145663

HS-(CH2)3CO-L-Ala-D-Ala-L-Ala-NH-CH2-S-(CH2)5-CO-DM	Drug-Linker Conjugates for ADC	Cancer
HS-(CH2)3CO-L-Ala-D-Ala-L-Ala-NH-CH2-S-(CH2)5-CO-DM is a agent-linker (peptide-cleavable) conjugate for ADC. DM indicates the maytansinoid moiety .

HY-122702

PEG6-(CH2CO2H)2	PROTAC Linkers	Others
PEG6-(CH2CO2H)2 is a symmetric PEG PROTAC linker, for the synthesis of Homo-PROTACs which is bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation .

HY-134708

Bromo-PEG3-CO-NH2

PROTAC Linkers Cancer

Bromo-PEG3-CO-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
HY-145367

Ala-CO-amide-C4-Boc

ADC Linker Cancer

Ala-CO-amide-C4-Boc is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

Bromo-PEG3-CO-NH2	PROTAC Linkers	Cancer
Bromo-PEG3-CO-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

Ala-CO-amide-C4-Boc	ADC Linker	Cancer
Ala-CO-amide-C4-Boc is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-13631F

Gly-Gly-Phe-Gly-NH-O-CO-Exatecan hydrochloride	Drug-Linker Conjugates for ADC	Cancer
Gly-Gly-Phe-Gly-NH-O-CO-Exatecan, as a drug-linker conjugate composed of linker Gly-Gly-Phe-Gly-NH-O-CO and Exatecan, can be used to prepare antibody conjugate drugs. Exatecan is a DNA topoisomerase I inhibitor that can be used in cancer research .

HY-131647

Pomalidomide 4'-PEG5-acid Pomalidomide-PEG5-Co2H	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide 4'-PEG5-acid (Pomalidomide-PEG5-CO2H) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 5-unit PEG linker used in PROTAC technology .

HY-W584525

VH032-NH-CO-CH2-NHBoc	Ligands for E3 Ligase	Cancer
VH032-NH-CO-CH2-NHBoc is a Boc-modified VH032 (HY-120217) that acts as a ligand for VHL to recruit von Hippel-Lindau (VHL) proteins. VH032-NH-CO-CH2-NHBoc will remove the Boc protection under acidic conditions, and connect with the target protein ligand through a linker to form a PROTAC molecule, which is a key intermediate for the synthesis of PROTAC based on VHL ligand.

HY-156882

Biotin-PEG3-amide-C2-CO-Halofuginone

Others Cancer

Biotin-PEG3-amide-C2-CO-Halofuginone, a kind halofuginone derivative, can be used in the cancer study .

HY-153043

DM-CO-(CH2)5-SMe	Drug Metabolite	Cancer
DM-CO-(CH2)5-SMe is an anticancer agent derived from antibody-drug conjugates (ADC) metabolite with cytotoxicity to H1703, H1975, COLO704 and Colo720E cells .

HY-140349

AZD-CO-C2-Ph-amido-Ph-azide	PROTAC Linkers	Cancer
AZD-CO-C2-Ph-amido-Ph-azide is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs . AZD-CO-C2-Ph-amido-Ph-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-131386A

BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride	Target Protein Ligand-Linker Conjugates	Cancer
BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride incorporates a ligand for PD-1/PD-L1 immune checkpoint, and a PROTAC linker. BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1 (HY-131183). PROTAC PD-1/PD-L1 degrader-1 inhibits PD-1/PD-L1 interaction with an IC₅₀ of 39.2 nM .

Cat. No.	Product Name

HY-L138

Heterocyclic Compound Library

5986 compounds

Heterocyclic compounds are cyclic organic compounds which contain at least one hetero atom, the most common heteroatoms are nitrogen, oxygen ,and sulfur. Heterocycles are common in biology, featuring a wide range of structures from enzyme co-factors to amino acids and proteins. On the one hand, heterocycles are common structural units in approved drugs and in medicinal chemistry targets in the drug discovery process. In addition, heterocycles have been found as a key structure in medical chemistry and also they are frequently found in large percent of biomolecules such as vitamins, natural products ,and biologically active compounds including antifungal, anti-inflammatory, antibacterial, antioxidant, antiallergic, anti-HIV, antidiabetic, anticancer activity.

MCE offers a unique collection of 5986 heterocyclic compounds which can be used for drug discovery for high throughput screening (HTS) and high content screening (HCS). MCE heterocyclic compound library is critical for drug discovery and development.

HY-L133

Cuproptosis Compound Library

187 compounds

Copper is an important co-factor of all biological enzymes, but if the concentration exceeds the threshold of maintaining the homeostasis mechanism, copper will lead to cytotoxicity. This death mechanism has been named "Cuproptosis".

The mechanism of cuproptosis distinct from all other known mechanisms of regulated cell death, including apoptosis, pyroptosis, necroptosis, and ferroptosis.

Copper combine with the lipoylated components of the tricarboxylic acid cycle (TCA), leading to lipoylated protein aggregation and subsequent loss of iron-sulfur cluster proteins, ultimately resulting in protein toxicity stress and cell death. Studies have shown that the necessary factors for cuproptosis include the presence of glutathione, mitochondrial metabolism of galactose and pyruvate, and glutamine metabolism.

Targeted regulation of cuproptosis is a potential choice to treat cancer, rheumatoid arthritis, and other diseases. For example, up-regulation of LIPT1 may inhibit the occurrence and development of tumors by destroying TCA in mitochondria and then inducing cuproptosis.

MCE supplies a unique collection of 187 cuproptosis-related compounds, all of which act on the targets or signaling pathways related to cuproptosis and may have in inhibitory or activated effect on cuproptosis. MCE Cuproptosis Library is a useful tool for drug research related to cancer, rheumatoid arthritis, and other diseases.

Cat. No.	Product Name	Type

HY-112276

Beryllon II	Chromogenic Assays
Beryllon II is a widely used chromogenic reagent that is used to determine many elements, such as Mo, Mg and Co, and also used for the determination of proteins.

HY-D0142

Pyrene-1,3,6,8-tetrasulfonic acid tetrasodium	Fluorescent Dyes/Probes
Pyrene-1,3,6,8-tetrasulfonic acid tetrasodium is a fluorescent dye and pH indicator, also as a ligand of multifunctional metal-organic framework. Pyrene-1,3,6,8-tetrasulfonic acid tetrasodium has been used to detect CO₂ release .

HY-D0996

LDS-751

DNA Stain

Lds-751 is a nucleic acid stain that mainly detects DNA. Lds-751 is a nucleic acid stain that mainly detects DNA. Lds-751 has a high affinity for DNA and fluorescence is enhanced after binding, but the maximum emission wavelength is 670nm. Lds-751 and Thiazole orange can be used for the differentiation of red blood cells, platelets, reticulocytes, and nucleated cells and can be stimulated at 488nm. Studies have shown that LDS-751 binds almost exclusively to mitochondria when incubated with nucleated living cells. After nucleated Acridine Orange (HY-101879) staining and LDS-751 treatment of cells, confocal microscopy revealed almost no co-location of the cells. Staining with Rhodamine 123 (HY-D0816), a dye known to bind polarized mitochondria, was almost identical to the pattern observed with LDS-751 .

HY-D1745

Liptracker-Green fac-[Re(Co)3(phen)L]	Fluorescent Dyes/Probes
Liptracker-green (fac-[Re(CO)3(phen)L]) is a cell-permeable fluorogenic probe that localizes to polar lipids, and can be used to label lipid droplets and other high lipid-content compartments in live and fixed cells using fluorescent microscopy.

HY-D0153

Tetramethylrhodamine-5-isothiocyanate	Fluorescent Dyes/Probes
Tetramethylrhodamine-5-isothiocyanate is a potent fluorescent dye. Tetramethylrhodamine-5-isothiocyanate can be used for label PG-M3 antibody for rapid diagnosis of acute promyelocytic leukemia (APL). Tetramethylrhodamine-5-isothiocyanate can be used as probe to quantify in vivo the biodistribution of PLGA (poly(lactic-co-glycolic) acid) and PLGA/chitosan nanoparticles .

Cat. No.	Product Name	Type

HY-W250116

Co(III) protoporphyrin IX chloride

Protoporphyrin IX Cobaltic chloride
Biochemical Assay Reagents

Co(III) Protoporphyrin IX chloride (CoPP) is an effective HO-1inducer.
HY-Y1887

Cottonseed oil

Co-solvents

Cottonseed oil is a cooking oil extracted from the seeds of cotton plants and has been generally considered the most insecticidal of vegetable oils.
HY-Y1888

Corn oil

55+ Cited Publications

Co-solvents

Corn oil, extracted from the germ of corn, can be used as a carrier for agent molecules.

HY-B2247

PLGA (50:50) 5+ Cited Publications poly(lactic-Co-glyColic acid) (50:50)	Drug Delivery
PLGA (50:50) (poly(lactic-co-glycolic acid) (50:50)) is a copolymer of poly lactic acid (PLA) and poly glycolic acid (PGA) which can be used to fabricate devices for drug delivery and tissue engineering applications.

HY-Y1911

Mid-chain triglyceride of caprylic/caprolic acid

Co-solvents

Mid-chain triglyceride of caprylic/caprolic acid can be used as a co-solvent.

HY-107799

Castor oil 2 Publications Verification	Co-solvents
Castor oil is a natural triglyceride and a solvent. Castor oil has a laxative effect and induces labor in pregnant females. Castor oil can be used as a solvent, co-solvent, stabilizing agent and polyol for the formation of polymer-nanoparticle composites .

HY-W250126

Ethylene-vinyl acetate copolymer Poly(ethylene-Co-vinyl acetate)	Biochemical Assay Reagents
Ethylene-vinyl acetate copolymer is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W019981C

Magnesium chloride hexahydrate, for cell culture MgCl2 hexahydrate, for cell culture	Buffer Reagents
Magnesium chloride hexahydrate, for cell culture is the hexahydrate form of magnesium dichloride. Magnesium chloride hexahydrate, for cell culture can be used as a source of magnesium ion and a co-foactor for many enzymes. Magnesium chloride hexahydrate, for cell culture increases the activity of Ca ²⁺ ATPase .

HY-144016

16:0 EPC chloride	Drug Delivery
16:0 EPC chloride, a P-O-ethyl derivative, is a saturated cationic lipid. 16:0 EPC chloride can serve as a DNA and RNA transfecting agent. 16:0 EPC chloride can be used as a co-adjuvant for preparing vaccines and promote drug delivery .

HY-157917

Nitro-PAPS disodium dihydrate	Chelators
Nitro-PAPS disodium dihydrate is a highly sensitive colometric reagent for Fe(II) detection with a maximal absorption wavelength of 592 nm. Nitro-PAPS disodium dihydrate is suitable for the determination of Fe(II) in serum and also be used to determine micro molar levels of Cu, Zn, Ni, Co and V .

HY-W250153

Adenosine 3'-phosphate 5'-phosphosulfate lithium	Biochemical Assay Reagents
Adenosine 3'-phosphate 5'-phosphosulfate lithium is a co-substrate used for the sulfonation of glycans. Adenosine 3'-phosphate 5'-phosphosulfate lithium can be used for Golgi-resident PAP-specific 3'-phosphatase-coupled sulfotransferase assays, which as donor substrate to transfer a sulfonate group .

HY-W250153A

Adenosine 3'-phosphate 5'-phosphosulfate lithium, hydrate	Biochemical Assay Reagents
Adenosine 3'-phosphate 5'-phosphosulfate lithium is a co-substrate used for the sulfonation of glycans. Adenosine 3'-phosphate 5'-phosphosulfate lithium can be used for Golgi-resident PAP-specific 3'-phosphatase-coupled sulfotransferase assays, which as donor substrate to transfer a sulfonate group .

HY-W011060

Cryptand 2.2.2 4,7,13,16,21,24-Hexaoxa-1,10-diazabicyclo[8.8.8]hexaCosane	Biochemical Assay Reagents
Cryptand 2.2.2 is a metal ion chelator that can be used as a reducing agent and stabilizer to prepare nanoparticles. At room temperature, Cryptand 2.2.2 can serve as a host molecule, using the chelation effect to selectively bind desired ions (such as Zn ²⁺, Co ²⁺, Ni ²⁺, Cu ²⁺) .

HY-147207C

Phospholipid-PEG-Biotin (MW 5000)

Drug Delivery

Phospholipid-PEG-Biotin (MW 5000) is a phospholipid PEG derivative, can be used for modify liposome and cells surface, and pancreatic islets for cell transplantation. Phospholipid is a class of lipid containing a hydrophilic “head” and two hydrophobic “tails”; PEG is a hydrophilic and water-soluble polymer with low toxicity; Biotin is an enzyme co-factor, can be used for labeling protein .

HY-147207A

Phospholipid-PEG-Biotin (MW 2000)

Drug Delivery

Phospholipid-PEG-Biotin (MW 2000) is a Biotin labeled phospholipid PEG derivative, can be used for modify liposome and cells surface, and pancreatic islets for cell transplantation. Phospholipid is a class of lipid containing a hydrophilic “head” and two hydrophobic “tails”; PEG is a hydrophilic and water-soluble polymer with low toxicity; Biotin is an enzyme co-factor, can be used for labeling protein .

HY-17031

SBE-β-CD 75+ Cited Publications Sulfobutylether-β-Cyclodextrin	Co-solvents
SBE-β-CD is a sulfobutylether β-cyclodextrin derivative used as an excipient or a formulating agent to increase the solubility of poorly soluble agents .

HY-101461

Methyl-β-cyclodextrin 40+ Cited Publications Methyl-beta-cyclodextrin	Co-solvents
Methyl-β-cyclodextrin (Methyl-beta-cyclodextrin) is a cyclic heptasaccharide used to deliver hydrophobic agents based on its property of solubilizing non-polar substances. Methyl-β-cyclodextrin is also extensively used as a cholesterol-depleting reagent . Methyl-β-cyclodextrin strongly reduces clathrin-dependent endocytosis . Methyl-β-cyclodextrin blocks cell migrasome formation .

HY-B1659

Glycerol

Trihydroxypropane
Co-solvents

Glycerol is used in sample preparation and gel formation for polyacrylamide gel electrophoresis.

HY-B1620

Polyvinylpyrrolidone PVP; Polyvidone; Povidone	Co-solvents
Polyvinylpyrrolidone is a compound which has been widely tested and used in human and veterinary medicine as an effective wound healing accelerator and disinfectant when combined with iodine and other compounds.

HY-Y1892

Gelucire 44/14 1 Publications Verification	Co-solvents
Gelucire 44/14 is a potential and safe absorption enhancer for improving the absorption of poorly absorbable agents including insulin and calcitonin by pulmonary delivery.

HY-Y1893

Solutol HS-15

5+ Cited Publications

Polyethylene glyCol 12-hydroxystearate
Co-solvents

Solutol HS-15, a Macrogol 15 hydroxy stearate, is a permeability enhancer .

HY-Y1890

Cremophor EL 5+ Cited Publications	Co-solvents
Cremophor EL, a polyoxyethylene castor oil derivative, is a nonionic surfactant. Cremophor EL is widely employed to improve dissolution and delivery of agents .

HY-Y0921

(±)-1,2-Propanediol 1 Publications Verification 1,2-(RS)-Propanediol; 1,2-Propylene glyCol; Propylene glyCol	Co-solvents
(±)-1, 2-propanediol (1,2-(RS)-Propanediol) is an aliphatic alcohol that is often used as an excipient in many active molecular preparations to increase the solubility and stability of the active molecule. (±)-1, 2-propanediol can affect the neurobehavior of zebrafish .

HY-W042416

N,N-Dimethylacetamide DMAc	Co-solvents
N,N-Dimethylacetamide (DMAc) is an organic solvent with blood-brain transmissibility and an FDA-approved drug excipient. N, N-dimethylacetamide exerts anti-inflammatory activity by inhibiting the NF-κB signaling pathway. N, N-dimethylacetamide can be used in studies of weight gain caused by a high-fat diet and neuroinflammation in Alzheimer's disease .

HY-Y1889

Sodium carboxymethyl cellulose (Viscosity:5000-15000 mPa.s) CMC-Na (VisCosity:5000-15000 mPa.s)	Co-solvents
Sodium carboxymethyl cellulose (Viscosity:5000-15000 mPa.s) is the sodium salt of cellulose arboxymethyl and frequently used as viscous agent, paste and barrier agent.

HY-Y0842

Formamide Methanamide; Formimidic acid	Co-solvents
Formamide is a denaturant of DNA which can lower DNA stability in aqueous buffer solutions. Formamide is also used as a solvent for many ionic compounds, resins and plasticizers or as a chemical feedstock .

HY-Y0873

PEG300 60+ Cited Publications Polyethylene glyCol 300	Co-solvents
PEG300 (Polyethylene glycol 300), a neutral polymer of molecular weight 300, is a water-soluble, low immunogenic and biocompatible polymer formed by repeating units of ethylene glycol .

HY-Y1891

Tween 80 40+ Cited Publications Polysorbate 80	Co-solvents
Tween 80 (Polysorbate 80), a surfactant, has been widely used as a solvent for pharmacological experiments. Tween 80 can also reduce bacterial attachment and inhibit biofilm formation.

HY-Y0873A

PEG400 10+ Cited Publications Polyethylene glyCol 400	Co-solvents
PEG400 is a strongly hydrophilic polyethylene glycol used as an excellent solvent for a large number of substances. PEG400 is widely used in a variety of pharmaceutical formulations.

HY-Y1903

Phosal 50 PG 3 Publications Verification	Co-solvents
Phosal 50 PG is a cosolvent (standardised phosphatidylcholine concentrate). Phosal 50 PG as a carrier for lipophilic compounds, can improve the absorption, efficacy and therapeutic index of the active ingredient .

HY-125861

Methyl cellulose 5 Publications Verification Methyl cellulose(VisCosity:100000mPa.s)	Co-solvents
Methylcellulose is a natural polymer which gels on heating. Methylcellulose is not toxic.

HY-126403

Ethoxylated hydrogenated castor oil PEG-40 hydrogenated castor oil; Macrogolglycerol hydroxystearate; Castor oil, hydrogenated, polyethoxylated	Co-solvents
Ethoxylated hydrogenated castor oil (PEG-40 hydrogenated castor oil) is a combination of synthetic polyethylene glycol (PEG) with natural castor oil. Ethoxylated hydrogenated castor oil can be used to emulsify and solubilize oil-in-water (o/w) emulsions. Ethoxylated hydrogenated castor oil can be used as a cosolvent in vivo .

HY-Y1275

N-Methylpyrrolidone NMP	Co-solvents
N-Methylpyrrolidone (1-Methyl-2-pyrrolidinone), a five-membered cyclic amide, is an organic polar solvent. N-Methylpyrrolidone is extensively used in the manufacture of adhesives, paints, fuels, and pharmaceuticals .

HY-Y1889A

Sodium carboxymethyl cellulose (MW 250000) 5+ Cited Publications CMC-Na (MW 250000); CMC-Na (VisCosity:1500-3100 mPa.s)	Co-solvents
Sodium carboxymethyl cellulose (CMC-Na) (MW 250000) is a sodium salt of carboxymethyl cellulose. Sodium carboxymethyl cellulose has adsorption and corrosion inhibition on low-carbon steel in an acidic medium. Sodium carboxymethyl cellulose can be used as a thickener, paste and barrier agent .

HY-Y0320

Dimethyl sulfoxide

Maximum Cited Publications

89 Publications Verification

DMSO

Co-solvents

Dimethyl sulfoxide (DMSO) is an aprotic solvent that dissolves polar and non-polar compounds, including water-insoluble therapeutic and toxic agents. Dimethyl sulfoxide (DMSO) has a strong affinity for water and can rapidly penetrate or enhance the penetration of other substances into biological membranes. Dimethyl sulfoxide also has potential free radical scavenging and anticholinesterase effects and may affect coagulation activity. Dimethyl sulfoxide also induces histamine release from mast cells but is thought to have low systemic toxicity. Dimethyl sulfoxide also exhibits antifreeze and antibacterial properties .
MCE provides Dimethyl sulfoxide that complies with the inspection standards (Ch.P) of Part 4 of the Chinese Pharmacopoeia (2020 Edition).

HY-ER010

1H-Imidazole hydrochloride

Imidazole hydrochloride

Co-solvents

1H-Imidazole hydrochloride can be used as ligand, buffer and catalyst, etc., and also plays an important role in the process of drug synthesis and extraction of natural products. In addition, the compound is widely used in certain industrial fields, such as in the manufacturing process of plastics, coatings, textiles and electronic materials. Although the compound has no direct medical applications, it plays an important role in chemical research and laboratory studies.

HY-Y0873L

PEG800

Polyethylene glyCol 800
Co-solvents

PEG800 (Polyethylene glycol 800) is a nonionic surfactant that is soluble in water and many polar solvents .

HY-Y0873K

PEG200 Polyethylene glyCol 200	Co-solvents
PEG200 (Polyethylene glycol 200), a neutral polymer of molecular weight 300, is a water-soluble, low immunogenic and biocompatible polymer formed by repeating units of ethylene glycol .

HY-Y0873C

PEG3350 Polyethylene glyCol 3350	Co-solvents
PEG3350 (Polyethylene glycol 3350) a neutral polymer of molecular weight 3350. PEG3350 used as an excellent solvent for a large number of substances.

HY-Y0873N

PEG3000 Polyethylene glyCol 3000	Co-solvents
PEG3000 (Polyethylene glycol 3000) is a solvent for a large number of substances. PEG3000 can be used as a carrier material and modifying agent. PEG3000 is widely used in a variety of pharmaceutical formulations .

HY-D1005A24

Poloxamer 402 (L122)

PEG-PPG-PEG, 5000 (Averag)

Co-solvents

Poloxamer 402 L122 (PEG-PPG-PEG, 5000 Averag) is a synthetic triblock copolymer of poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) (PEO-PPO-PEO). Poloxamer 402 L122 forms thermoreversible gel, which remains fluid at room temperature but becomes more viscous gel at body temperature. Poloxamer 402 L122 is utilized in drug delivery, tissue regeneration and generation of micellar system .

HY-D1005A1

Poloxamer 101 (L31) PEG-PPG-PEG, 1100 (Averag)	Co-solvents
Poloxamer 101 L31 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 1100. Poloxamer 101 L31 forms hydrogel, that is utilized as surfactants and emulsifying agents. Poloxamer 101 L31 induces slight alveolitis .

HY-D1005A10

Poloxamer 184 (L64)

PEG-PPG-PEG, 2900 (Averag)

Co-solvents

Poloxamer 184 L64 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 2900. Poloxamer 184 L64 exhibts short-term dermal toxicity characterized by slight erythema and intradermal inflammatory response. Poloxamer 184 L64 exhibits antimicrobial activity, that inihibits 60% Mycobacterium avium complex at concentration of 1 mg/mL. Poloxamer 184 L64 forms thermoreversible hydrogel, that is utilized in food additives, drug delivery carriers in cosmetics, pharmaceutical ingredients and tissue engineering .

HY-D1005A11

Poloxamer 185 (P65) PEG-PPG-PEG, 3400 (Averag)	Co-solvents
Poloxamer 185 P65 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 3400. Poloxamer 185 P65 forms thermoreversible hydrogel, that is utilized in food additives, drug delivery carriers in cosmetics, pharmaceutical ingredients and tissue engineering .

HY-D1005A12

Poloxamer 212 (L72) PEG-PPG-PEG, 2750 (Averag)	Co-solvents
Poloxamer 212 L72 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 2750. Poloxamer 212 L72 forms thermoreversible hydrogel, that is utilized in food additives, drug delivery carriers in cosmetics, pharmaceutical ingredients and tissue engineering .

HY-D1005A13

Poloxamer 215 (P75) PEG-PPG-PEG, 4150 (Averag)	Co-solvents
Poloxamer 215 P75 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 4150. Poloxamer 215 P75 forms thermoreversible hydrogel, that is utilized in food additives, drug delivery carriers in cosmetics, pharmaceutical ingredients and tissue engineering .

HY-D1005A14

Poloxamer 217 (F77) PEG-PPG-PEG, 6600 (Averag)	Co-solvents
Poloxamer 217 F77 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 6600. Poloxamer 217 F77 inhibits proliferation of human lymphocyte cell IIBR1 .

HY-D1005A15

Poloxamer 234 (P84) PEG-PPG-PEG, 4200 (Averag)	Co-solvents
Poloxamer 234 P84 is is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 4200. Poloxamer 234 P84 forms thermoreversible hydrogel, that is utilized in food additives, drug delivery carriers in cosmetics, pharmaceutical ingredients and tissue engineering .

HY-D1005A16

Poloxamer 235 (P85) PEG-PPG-PEG, 4600 (Averag)	Co-solvents
Poloxamer 235 P85 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 4600. Poloxamer 235 P85 exhibits acute and subchronic toxicity in albino rats with an oral LD₅₀ of >34.6 g/kg. Poloxamer 235 P85 induces ocular irritation in rabbits .

HY-D1005A17

Poloxamer 238 (F88) PEG-PPG-PEG, 11400 (Averag)	Co-solvents
Poloxamer 238 F88 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 11400. Poloxamer 238 F88 reduces the aggregation of red blood cells. Poloxamer 238 F88 forms thermoreversible hydrogel, that is utilized in food additives, drug delivery carriers in cosmetics, pharmaceutical ingredients and tissue engineering .

Cat. No.	Product Name	Target	Research Area

HY-P1212

Cortistatin 14, human, rat CST-14, human, rat	Somatostatin Receptor	Neurological Disease
Cortistatin 14, human, rat (CST-14, human, rat), a neuropeptide with neuronal depressant and sleep modulating properties, can bind to all five cloned somatostatin receptors (SSTRs) and ghrelin receptor to exert its biological activities and co-exists with GABA within the cortex and hippocampus .

HY-P5326

EDANS-CO-CH2-CH2-CO-ALERMFLSFP-Dap(DABCYL)OH

Peptides Others

EDANS-CO-CH2-CH2-CO-ALERMFLSFP-Dap(DABCYL)OH is a biological active peptide. (Plasmepsin I substrate)

HY-P10215

Ac-{Cpg}-Thr-Ala-{Ala(CO)}-Asp-{Cpg}-NH2	Peptides	Infection
Ac-{Cpg}-Thr-Ala-{Ala(CO)}-Asp-{Cpg}-NH2 (compound 40) is a potent Plasmodium subtilisin-like protease 1 (SUB1) inhibitor. SUB1-IN-1 shows IC₅₀ values of 12 nM and 10 nM against P. vivax and P. falciparum SUB1 (Pv- and PfSUB1), respectively .

HY-P2229

Ilatreotide SDZ Co 611	Somatostatin Receptor	Cancer
Ilatreotide (SDZ CO61), glycated somatostatin derivative, is a highly potent glycated analog of somatostatin with improved oral activity. Ilatreotide can suppress the fasting level and postprandial release of several gastrointestinal and pancreatic hormones. Ilatreotide can be used for the research of gastroenteropancreatic tumors .

HY-P4772

Me-CO-Lys(Cbo)-Gly-Arg-pNA

Peptides Others

Me-CO-Lys(Cbo)-Gly-Arg-pNA is a substrate for C1 esterase .

HY-P10061

Cathepsin K inhibitor 4	Cathepsin	Cancer
Cathepsin K inhibitor 4 is a potent carbohydrazide Cathepsin K inhibitor with IC₅₀s of 13 nM, 269 nM, 296 nM for human, rat, mouse Cathepsin K, respectively .

HY-16381

Pasireotide SOM230	Somatostatin Receptor	Endocrinology Cancer
Pasireotide (SOM230), a long-acting cyclohexapeptide somatostatin analogue, can improve agonist activity at somatostatin receptors (subtypes sst1/2/3/4/5, pK_i=8.2/9.0/9.1/<7.0/9.9, respectively). Pasireotide can suppress GH, IGF-I and ACTH secretion, indicating potential efficacy in acromegaly and Cushing's disease. Pasireotide also exhibits antisecretory, antiproliferative, and proapoptotic activity .

HY-P10032

NN1177 NNC9204-1177	GCGR GLP Receptor Cytochrome P450	Metabolic Disease
NN1177 is a long-acting GLP-1/glucagon receptor co-agonist. NN1177 can induce a dose-dependent body weight loss in diet-induced obese (DIO) mice .

HY-P10032A

NN1177 TFA NNC9204-1177 TFA	GCGR Cytochrome P450 GLP Receptor	Metabolic Disease
NN1177 (NNC9204-1177) TFA is a long-acting GLP-1/glucagon receptor co-agonist. NN1177 TFA can induce a dose-dependent body weight loss in diet-induced obese (DIO) mice .

HY-150093

CAM741	Peptides	Inflammation/Immunology Cancer
CAM741 is a selective VCAM-1 translocation inhibitor. CAM741 selectively inhibits VCAM-1 expression by inhibiting its co-translational translocation within the lumen of the endoplasmic reticulum (ER). CAM741 can be used as a molecular tool and can also be used in the research of chronic inflammation and cancer .

HY-P0084

Cyclic somatostatin SRIF-14; Somatostatin-14	Peptides	Cardiovascular Disease Neurological Disease
Cyclic somatostatin (SRIF-14) is a growth hormone-release inhibiting factor used in the research of severe, acute hemorrhages of gastroduodenal ulcers. Cyclic somatostatin is a neuropeptide co-stored with acetylcholine in the cardiac parasympathetic innervation, exerts influences directly on contraction of ventricular cardiomyocytes. Cyclic somatostatin inhibits the contractile response of isoprenaline with an IC₅₀ value of 13 nM. Cyclic somatostatin can be used for the research of cardiovascular disease .

HY-P1698

Reltecimod AB-103	Bacterial CD28	Infection Inflammation/Immunology
Reltecimod (AB-103) is a T-cell-specific surface glycoprotein CD28 (TP44) antagonist. Reltecimod has beneficial effects against different bacterial infections, their exotoxins and endotoxins, and ionizing radiation. Reltecimod modulates the inflammatory response by targeting and attenuating the critical CD28/B7-2 co-stimulatory pathway, without inhibiting it. Reltecimod can be used to research necrotizing soft-tissue infections (NSTIs) .

HY-P1698B

Reltecimod TFA AB-103 TFA	Bacterial CD28	Infection Inflammation/Immunology
Reltecimod (AB-103) TFA is a T-cell-specific surface glycoprotein CD28 (TP44) antagonist. Reltecimod TFA has beneficial effects against different bacterial infections, their exotoxins and endotoxins, and ionizing radiation. Reltecimod TFA modulates the inflammatory response by targeting and attenuating the critical CD28/B7-2 co-stimulatory pathway, without inhibiting it. Reltecimod TFA can be used to research necrotizing soft-tissue infections (NSTIs) .

HY-P3375

Mazdutide IBI-362; LY-3305677; OXM-3	GCGR GLP Receptor	Metabolic Disease
Mazdutide (IBI-362; LY-3305677) is a long-acting synthetic oxyntomodulin analog. Mazdutide is also a co-agonist of glucagon-like peptide (GLP-1R) and glucagon receptor (GCGR). Mazdutide binds human and mouse GCGR (K_i: 17.7 nM and 15.9 nM, respectively) and GLP-1R (K_i: 28.6 nM and 25.1 nM, respectively) and stimulates insulin secretion from mouse islets (EC₅₀: 5.2 nM). Mazdutide is used in studies of obesity and type 2 diabetes (T2D) .

HY-P3375A

Mazdutide TFA IBI-362 TFA; LY-3305677 TFA; OXM-3 TFA	GCGR GLP Receptor	Metabolic Disease
Mazdutide (IBI-362; LY-3305677) TFA is a long-acting synthetic oxyntomodulin analog. Mazdutide is also a co-agonist of glucagon-like peptide (GLP-1R) and glucagon receptor (GCGR). Mazdutide TFA binds human and mouse GCGR (K_i: 17.7 nM and 15.9 nM, respectively) and GLP-1R (K_i: 28.6 nM and 25.1 nM, respectively) and stimulates insulin secretion from mouse islets (EC₅₀: 5.2 nM). Mazdutide TFA is used in studies of obesity and type 2 diabetes (T2D) .

HY-P5357

SFNGGP-NH2	Protease Activated Receptor (PAR)	Others
SFNGGP-NH2 is a biological active peptide. (PAR-3 is a high-affinity thrombin receptor. PAR-3 mRNA is expressed in the cutaneous mast cells of humans. Protease-Activated Receptors (PARs) have been studied for their roles in itch and their itch-associated response through histamine-dependent/independent pathways have been reported. PAR-3 has been shown not to induce itching alone but possibly in conjunction with PAR-4. Co-expression of PAR-3 and PAR-4 enhances thrombin action suggesting that PAR-3 alone does not mediate transmembrane signaling but instead functions as a cofactor to activate PAR-4.)

Cat. No.	Product Name

HY-K0203

Protein A Magnetic Beads 10+ Cited Publications
Protein A Magnetic Beads provide a fast and convenient method for Immunoprecipitation and Co-Immunoprecipitation and Chromatin Immunoprecipitation.

HY-K0205

Protein L Magnetic Beads 5+ Cited Publications
Protein L Magnetic Beads provide a fast and convenient method for Immunuoprecipitaion, Co-Immunoprecipitation and Chromatin Immunoprecipitation.

HY-K0204

Protein G Magnetic Beads 10+ Cited Publications
Protein G Magnetic Beads provide a fast and convenient method for Immunoprecipitation and Co-Immunoprecipitation and Chromatin Immunoprecipitation.

HY-K0202

Protein A/G Magnetic Beads Maximum Cited Publications 492 Publications Verification
The MCE Protein A/G Magnetic Beads provide a fast and convenient method for Immunoprecipitation, Co-Immunoprecipitation and Chromatin Immunoprecipitation.

HY-K0207

Anti-Flag Magnetic Beads 65+ Cited Publications
MCE Anti-Flag Magnetic Beads are used for immunoprecipitation (IP) of specific Flag-tagged proteins expressed in bacterial and mammalian cells and in vitro expression systems, and also suitable for Co-immunoprecipitation and purification of Flag-tagged protein.

HY-K0207A

Anti-Flag Magnetic Beads (1 μm) 1 Publications Verification
MCE Anti-Flag Magnetic Beads are used for immunoprecipitation (IP) of specific Flag-tagged proteins expressed in bacterial and mammalian cells and in vitro expression systems, and also suitable for Co-immunoprecipitation and purification of Flag-tagged protein.

Cat. No.	Product Name	Target	Research Area

HY-P99231

Edrecolomab Panorex; Co17-1A	Inhibitory Antibodies	Cancer
Edrecolomab (Panorex) is a murine monoclonal antibody to the cell-surface glycoprotein 17-1A, expressed on epithelial tissues and on various carcinomas. Edrecolomab shows anti-tumor activity and can be used in colorectal carcinoma research .

HY-P99387

TSR-033	LAG-3	Cancer
TSR-033 is a high affinity human IgG4 antibody targeting LAG-3 (lymphocyte activation gene-3), a co-receptor associated with impaired T cell function and often co-expressed with PD-1, that enhances T cell function and PD-1 blocking activity in vitro and in vivo. TSR-033 has anti-tumor activity .

HY-P99836

Cudarolimab IBI101	Orexin Receptor (OX Receptor)	Inflammation/Immunology Cancer
Cudarolimab (IBI101) is a completely human anti-OX40 (CD134, a co stimulating molecule expressed by activated immune cells) antibody. Cudarolimab inhibits the binding of OX40 to its ligand OX40L. Cudarolimab has antitumor activity and can be used in cancer related research .

HY-108829

Abatacept CTLA4lg; BMS-188667	CTLA-4	Inflammation/Immunology Cancer
Abatacept (CTLA4lg) is a soluble fusion protein consisting of the extra-cellular domain of human CTLA4 and a fragment of the Fc portion of human IgG1 (hinge and CH2 and 3 domains) . Abatacept is a selective T-cell co-stimulation modulator and a protein agent for the autoimmune diseases .

HY-108829A

Abatacept (powder) CTLA4lg (powder); BMS-188667 (powder)	CTLA-4	Inflammation/Immunology Cancer
Abatacept (CTLA4lg; BMS-188667) powder is a soluble fusion protein consisting of the extra-cellular domain of human CTLA4 and a fragment of the Fc portion of human IgG1 (hinge and CH2 and 3 domains). Abatacept powder is a selective T-cell co-stimulation modulator and a protein agent for the autoimmune diseases .

HY-P990093

Stapokibart CM310	Interleukin Related	Inflammation/Immunology
Stapokibart (CM310) is a humanised monoclonal antibody targeting IL-4Rα and efficiently blocks the interaction of cytokines IL-4 and IL-13 with their co-receptor subunit IL-4Rα. Stapokibart has the capacity to interact with IL-4Rα in humans, cynomolgus monkeys, and rats .

HY-P99382

Vopratelimab JTX 2011	Inhibitory Antibodies	Inflammation/Immunology Cancer
Vopratelimab (JTX-2011) is a humanized immunoglobulin G1-kappa agonist monoclonal antibody that pecifically binds to the Inducible CO-Stimulator of T cells (ICOS). Vopratelimab retains species cross-reactivity with affinities of 0.93 nM to hICOS, 0.46 nM to cynomolgus ICOS, 3.7 nM to rat ICOS, and 0.64 nM to mICOS. Vopratelimab has antitumor immune response .

HY-P990033

Anzurstobart CC-95251; BMS-986351	Inhibitory Antibodies	Cancer
Anzurstobart (CC-95251; BMS-986351) is a high-affinity, fully human monoclonal anti-SIRPα antibody that blocks the binding of CD47 to SIRPα. Anzurstobart enhances macrophage phagocytic activity against DLBCL cell lines in co-culture models when combined with the antibody Rituximab (HY-P9913). Anzurstobart has the potential for solid and hematologic malignancies research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-107799

Castor oil 2 Publications Verification	Structural Classification Natural Products Classification of Application Fields Ricinus communis L. Source classification Other Diseases Euphorbiaceae Plants Disease Research Fields	Biochemical Assay Reagents
Castor oil is a natural triglyceride and a solvent. Castor oil has a laxative effect and induces labor in pregnant females. Castor oil can be used as a solvent, co-solvent, stabilizing agent and polyol for the formation of polymer-nanoparticle composites .

HY-N11684

Cocoa butter	Structural Classification Natural Products Source classification Sterculiaceae Theobroma cacao Linn. Plants	Biochemical Assay Reagents
Cocoa butter can be used as an excipient, such as lubricants, suppository bases. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs .

HY-131591

Digalacturonic acid	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Digalacturonic acid is a metabolite of pectin or pectic acid. Digalacturonic acid can be used for the co-crystallization of enzymes such as proteinase K .

HY-123174

Demethoxyrapamycin AY-24668	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Antibiotic Fungal
Demethoxyrapamycin (AY-24668) is a potent antifungal antibiotic which is co-produced with rapamycin by Streptomyces hygroscopicus .

HY-N8224

5-O-Cinnamoylquinic acid	Hydrangea macrophylla (Thunb.) Ser. Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Pigments Plants Saxifragaceae Disease Research Fields Food Research	Others
5-O-Cinnamoylquinic acid is a co-pigment. 5-O-Cinnamoylquinic acid could form the stable blue solution .

HY-113451

3-Hydroxysebacic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
3-Hydroxysebacic acid is an endogenous metabolite present in Urine that can be used for the research of Medium Chain Acyl Co A Dehydrogenase Deficiency .

HY-W004297

1-Nonadecanol	Natural Products other families Classification of Application Fields Source classification Other Diseases Plants Disease Research Fields	Others
1-Nonadecanol is one of the compositions of supercritical carbon dioxide (SC-CO₂) essential oil of Heracleum thomsonii. 1-Nonadecanol is also an important aroma compound in Neotinea ustulata .

HY-100196A

Pyrroloquinoline quinone disodium salt 2 Publications Verification PQQ disodium salt; Methoxatin disodium salt	Quinones Structural Classification Microorganisms Classification of Application Fields Source classification Benzene Quinones Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite
Pyrroloquinoline quinone disodium salt, a redox co-factor, is an anionic, redox-cycling orthoquinone. Pyrroloquinoline quinone disodium salt is isolated from cultures of methylotropic bacteria and tissues of mammals. Pyrroloquinoline quinone disodium salt is an essential nutrient for mammals and is important for immune function .

HY-N12534

Monaspin B	Structural Classification Natural Products Microorganisms Source classification	Apoptosis
Monaspin B is a natural product produced by the co-culture of Monascus purpureus and Aspergillus oryzae. Monaspin B exerts anti-proliferation activity by inducing apoptosis of HL-60 cells, IC₅₀ 160 nM. Monaspin B has antitumor activity .

HY-N8224A

(E)-5-O-Cinnamoylquinic acid	Animals Ketones, Aldehydes, Acids Source classification Phenylpropanoids	Others
(E)-5-O-Cinnamoylquinic acid is the isomer of 5-O-Cinnamoylquinic acid. 5-O-Cinnamoylquinic acid is a co-pigment. 5-O-Cinnamoylquinic acid could form the stable blue solution to clarify the mechanism of blue sepal-color development of hydrangea .

HY-Y0966

Glycine 4 Publications Verification	Structural Classification Human Gut Microbiota Metabolites Microorganisms Neurological Disease Classification of Application Fields Anti-aging Ketones, Aldehydes, Acids Source classification Disease markers Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite iGluR VEGFR Small Interfering RNA (siRNA)
Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors. Glycine is orally active. Glycine can be used to study cell protection, cancer, neurological diseases, and angiogenesis .

HY-122341

Thrazarine FR 900840	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Antibiotic
Thrazarine (FR 900840) is an oncology antibiotic that can be produced by Streptomyces coerulescens MH802-fF5. Thrazarine directly inhibits DNA synthesis and tumor cell growth. Thrazarine can specifically induce lysis of tumor cells co-cultured with non-activated macrophages. Thrazarine is used in cancer research .

HY-B1746

Pyridoxamine 5′-phosphate	Structural Classification Alkaloids Human Gut Microbiota Metabolites Neurological Disease Classification of Application Fields Source classification Pyridine Alkaloids Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Pyridoxamine 5′-phosphate is the active form of vitamin B6 bound to phosphoric acid. Pyridoxamine 5′-phosphate is the aminated form of pyridoxal 5'-phosphate hydrate (HY-W011727A) and as co-factor of a variety of enzymes central metabolite, potent antioxidant, vitamin B6 vitamer and enzyme substrate. Pyridoxamine 5′-phosphate can be interconverted with pyridoxal 5'-phosphate hydrate .

HY-B0399

L-Carnitine 5+ Cited Publications (R)-Carnitine; Levocarnitine	Structural Classification Natural Products Neurological Disease Source classification Endocrine diseases Endogenous metabolite Human Gut Microbiota Metabolites Microorganisms Immune System Disorder Disease markers Nervous System Disorder Disease Research Fields Cancer	Endogenous Metabolite
L-Carnitine ((R)-Carnitine), a highly polar, small zwitterion, is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine is an antioxidant. L-Carnitine can ameliorate metabolic imbalances in many inborn errors of metabolism .

HY-B2246

L-Carnitine hydrochloride 5+ Cited Publications (R)-Carnitine hydrochloride; Levocarnitine hydrochloride	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
L-Carnitine hydrochloride ((R)-Carnitine hydrochloride), a highly polar, small zwitterion, is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine hydrochloride functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine hydrochloride is an antioxidant. L-Carnitine hydrochloride can ameliorate metabolic imbalances in many inborn errors of metabolism .

HY-B1659

Glycerol Trihydroxypropane	Cardiovascular Disease Structural Classification Natural Products Classification of Application Fields Anti-aging Source classification Endocrine diseases Endogenous metabolite Human Gut Microbiota Metabolites Microorganisms Immune System Disorder Disease markers Inflammation/Immunology Disease Research Fields Cardiovascular System Disorder Cancer	Endogenous Metabolite
Glycerol is used in sample preparation and gel formation for polyacrylamide gel electrophoresis.

HY-Y0921

(±)-1,2-Propanediol 1 Publications Verification 1,2-(RS)-Propanediol; 1,2-Propylene glyCol; Propylene glyCol	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease markers Other Diseases Endogenous metabolite Disease Research Fields Cardiovascular System Disorder	Endogenous Metabolite
(±)-1, 2-propanediol (1,2-(RS)-Propanediol) is an aliphatic alcohol that is often used as an excipient in many active molecular preparations to increase the solubility and stability of the active molecule. (±)-1, 2-propanediol can affect the neurobehavior of zebrafish .

HY-Y0842

Formamide Methanamide; Formimidic acid	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Biochemical Assay Reagents
Formamide is a denaturant of DNA which can lower DNA stability in aqueous buffer solutions. Formamide is also used as a solvent for many ionic compounds, resins and plasticizers or as a chemical feedstock .

HY-Y0320

Dimethyl sulfoxide Maximum Cited Publications 89 Publications Verification DMSO	Microorganisms Source classification	Bacterial Cholinesterase (ChE)
Dimethyl sulfoxide (DMSO) is an aprotic solvent that dissolves polar and non-polar compounds, including water-insoluble therapeutic and toxic agents. Dimethyl sulfoxide (DMSO) has a strong affinity for water and can rapidly penetrate or enhance the penetration of other substances into biological membranes. Dimethyl sulfoxide also has potential free radical scavenging and anticholinesterase effects and may affect coagulation activity. Dimethyl sulfoxide also induces histamine release from mast cells but is thought to have low systemic toxicity. Dimethyl sulfoxide also exhibits antifreeze and antibacterial properties . MCE provides Dimethyl sulfoxide that complies with the inspection standards (Ch.P) of Part 4 of the Chinese Pharmacopoeia (2020 Edition).

HY-W250795

Maltodextrin, dextrose equivalent 16.5-19.5 Maltodextrin; Dextrin maize starch	Structural Classification Polysaccharides Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields Saccharides	Endogenous Metabolite
Maltodextrin, dextrose equivalent 16.5-19.5 can be used as an excipient. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs .

HY-134664

8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Compositae Vachellia nilotica (L.) P. J. H. Hurter & Mabb.	Cytochrome P450 Monoamine Oxidase
8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate is an irreversible CYP2A6 inhibitor with IC₅₀s of 8.64 μM and 22.3 μM with pre-incubation and co-incubaition, respectively. 8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate also inhibits MAO-A and MAO-B with IC₅₀s of 60.2 and 38.6 μM, respectively .

HY-W145516

Guar gum	Structural Classification Natural Products Leguminosae Source classification Cyamopsis tetragonoloba (L.) Taub. Plants	Biochemical Assay Reagents
Guar gum is a versatile polymer for drug delivery applications. Guar gum diaplays thickening, emulsifying, binding and gelling properties, quick solubility in cold water, wide pH stability, film forming ability and biodegradability, it finds applications in large number of industries. Guar gum can be isolated from the powdered endosperm of the seeds of the Cyamopsis tetragonolobus. Guar gum can be used as an excipient, such as thickener, suspending agent. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs .

Species:	Human (21) Mouse (2) Cynomolgus (1)
Tag:	His (19) SUMO (4) Tag Free (2) Avi (6) GST (3) Fc (1)
Source:	HEK293 (10) E. coli Cell-free (1) Sf9 insect cells (3) E. coli (10)

Cat. No.	Compare	Product Name	Species	Source

HY-P76117

	TSPAN8 Protein, Human (HEK293, His) Tetraspanin-8; Tspan-8; Co-029; TSPAN8; TM4SF3	Human	HEK293
	TSPAN8 is a cell surface glycoprotein that is complexed with integrins and belongs to the four-span protein family. It has four hydrophobic domains. TSPAN8 mediates extracellular signal transduction processes and regulates cell development, activation, growth, and movement. In addition, TSPAN8 is expressed in different cancers and has potential roles in cancer prognosis and targeted therapy. TSPAN8 Protein, Human (HEK293, His) is the recombinant human-derived TSPAN8 protein, expressed by HEK293 , with N-His, N-6*His labeled tag. The total length of TSPAN8 Protein, Human (HEK293, His) is 96 a.a., with molecular weight of ~17 & 13 kDa, respectively.

HY-P72086

	AQP1 Protein, Human (GST) AQP 1; AQP CHIP; AQP-1; AQP1; AQP1_HUMAN; aquaporin 1 channel-forming integral protein; 28kDa; Co blood group; ; aquaporin 1 Colton blood group; ; Aquaporin CHIP; Aquaporin-1; Aquaporin-CHIP; Aquaporin1; Channel forming integral protein 28kDa; Channel like integral membrane protein 28 kDa; CHIP 28; CHIP28; Co;	Human	E. coli
	The AQP1 protein forms water-specific channels that allow water to cross red blood cells and renal proximal tubule membranes. AQP1 Protein, Human (GST) is the recombinant human-derived AQP1 protein, expressed by E. coli , with N-GST labeled tag. The total length of AQP1 Protein, Human (GST) is 50 a.a., with molecular weight of ~31 kDa.

HY-P76118

	TSPAN8 Protein, Human (HEK293, Fc) Tetraspanin-8; Tspan-8; Co-029; TSPAN8; TM4SF3	Human	HEK293
	TSPAN8 is a cell surface glycoprotein that is complexed with integrins and belongs to the four-span protein family. It has four hydrophobic domains. TSPAN8 mediates extracellular signal transduction processes and regulates cell development, activation, growth, and movement. In addition, TSPAN8 is expressed in different cancers and has potential roles in cancer prognosis and targeted therapy. TSPAN8 Protein, Human (HEK293, Fc) is the recombinant human-derived TSPAN8 protein, expressed by HEK293 , with N-mFc labeled tag. The total length of TSPAN8 Protein, Human (HEK293, Fc) is 96 a.a., with molecular weight of ~46 kDa.

HY-P700697

	C2/Complement C2 Protein, Cynomolgus (HEK293, His) Complement C2; C3/C5 Convertase; C2; ARMD14; Co2	Cynomolgus	HEK293
	Complement C2 is a component of the classical pathway of the complement system and is cleaved by activated factor C1, resulting in the formation of two distinct fragments: C2b and C2a. The subsequent serine protease activity of C2a is critical for its subsequent interaction with the complement factor C4b, leading to the formation of C3 or C5 convertase. C2/Complement C2 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived C2/Complement C2 protein, expressed by HEK293 , with C-His labeled tag. The total length of C2/Complement C2 Protein, Cynomolgus (HEK293, His) is 732 a.a., with molecular weight of 90-110 kDa.

HY-P72147

	COL4A2 Protein, Human (His) 1 Publications Verification Canstatin; Co4A2_HUMAN; CoL4A 2; Col4a2; Collagen alpha 2IV; chain; Collagen; type IV; alpha 2	Human	E. coli
	COL4A2 protein is a key type IV collagen element that forms the main structural component of the glomerular basement membrane (GBM), forming a unique "chicken wire" network structure with laminin, proteoglycans and nestin/nesidin. . Canstatin is a cleavage product of the NC1 domain of collagen α 2(IV) and has potent anti-angiogenic and anti-tumor activities. COL4A2 Protein, Human (His) is the recombinant human-derived COL4A2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of COL4A2 Protein, Human (His) is 220 a.a., with molecular weight of ~28.3 kDa.

HY-P72085

	AQP1 Protein, Human (His-SUMO) AQP 1; AQP CHIP; AQP-1; AQP1; AQP1_HUMAN; aquaporin 1 channel-forming integral protein; 28kDa; Co blood group; ; aquaporin 1 Colton blood group; ; Aquaporin CHIP; Aquaporin-1; Aquaporin-CHIP; Aquaporin1; Channel forming integral protein 28kDa; Channel like integral membrane protein 28 kDa; CHIP 28; CHIP28; Co; Colton blood group; Growth factor induced delayed early response protein; MGC26324; Urine water channel; Water channel protein CHIP 29; Water channel protein CHIP29; Water channel protein for red blood cells and kidney proximal tubule	Human	E. coli
	The AQP1 protein forms water-specific channels that allow water to cross red blood cells and renal proximal tubule membranes. AQP1 Protein, Human (His-SUMO) is the recombinant human-derived AQP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of AQP1 Protein, Human (His-SUMO) is 50 a.a., with molecular weight of ~21.6 kDa.

HY-P700377

	Aquaporin-1/AQP1 Protein, Human (Cell-Free, His-SUMO) AQP CHIP; AQP-1; AQP1; AQP1_HUMAN; aquaporin 1 channel-forming integral protein; 28kDa; Co blood group; ; aquaporin 1 Colton blood group; ; Aquaporin CHIP; Aquaporin-1; Aquaporin-CHIP; Aquaporin1; Channel forming integral protein 28kDa; Channel like integral membrane protein 28 kDa; CHIP 28; CHIP28; Co; Colton blood group; Growth factor induced delayed early response protein; MGC26324; Urine water channel; Water channel protein CHIP 29; Water channel protein CHIP29; Water channel protein for red blood cells and kidney proximal tubule	Human	E. coli Cell-free
	The AQP1 protein forms water-specific channels that allow water to cross red blood cells and renal proximal tubule membranes. Aquaporin-1/AQP1 Protein, Human (Cell-Free, His-SUMO) is the recombinant human-derived Aquaporin-1/AQP1 protein, expressed by E. coli Cell-free , with N-SUMO, N-6*His labeled tag. The total length of Aquaporin-1/AQP1 Protein, Human (Cell-Free, His-SUMO) is 268 a.a., with molecular weight of 41.3 kDa.

HY-P72183

	EpCAM/TROP1 Protein, Human (His-SUMO) 17 1A; 323/A3; Adenocarcinoma associated antigen; Adenocarcinoma-associated antigen; Antigen identified by monoclonal AUA1; AUA1; CD326; CD326 antigen; Cell surface glyCoprotein Trop 1; Cell surface glyCoprotein Trop 2; Cell surface glyCoprotein Trop-1; Co 17A; Co17 1A; Co17A; DIAR5; EGP 2; EGP; EGP2; EGP314; EGP40; Ep CAM; Ep-CAM; EPCAM; EPCAM_HUMAN; EpCAM1; Epithelial cell adhesion molecule; Epithelial Cell Adhesion Molecule Intracellular Domain EpCAM-ICD; ; Epithelial cell surface antigen; Epithelial cellular adhesion molecule; Epithelial glyCoprotein 1; Epithelial glyCoprotein 314; Epithelial glyCoprotein; ESA; GA733 1; GA733 2; GA733-2; gastrointestinal tumor-associated antigen 2; 35-KD glyCoprotein; gp4; hEGP 2; hEGP314; HNPCC8; Human epithelial glyCoprotein 2; KS 1/4 antigen; KS1/4; KSA; Ly74; Lymphocyte antigen 74; M1S 1; M1S2; M4S1; Major gastrointestinal tumor associated protein GA733 2; Major gastrointestinal tumor-associated protein GA733-2; mEGP314; Membrane Component chro	Human	E. coli
	The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of EpCAM/TROP1 Protein, Human (His-SUMO) is 242 a.a., with molecular weight of ~40.4 kDa.

HY-P72148

	COL4A3 Protein, Human (His) Alpha 3 type IV Collagen; Alpha3 type IV Collagen; Co4A3_HUMAN; CoL4A 3; Col4a3; Collagen alpha 3IV; chain; Collagen IV alpha 3 polypeptide; Collagen type IV alpha 3 Goodpasture antigen; ; Collagen type IV alpha 3; Collagen type IV alpha 3 chain; Goodpasture antigen; OTTHUMP00000195044; Tumstatin	Human	E. coli
	The COL4A3 protein is an important type IV collagen component that, together with laminin, proteoglycans, and nestin/nesidin, plays a role in forming the "chicken wire" network structure in the glomerular basement membrane (GBM). Key role. Its cleavage product tumstatin is derived from the NC1 domain of collagen α 3(IV) and has dual anti-angiogenic and anti-tumor cell activities. COL4A3 Protein, Human (His) is the recombinant human-derived COL4A3 protein, expressed by E. coli , with N-6*His labeled tag. The total length of COL4A3 Protein, Human (His) is 242 a.a., with molecular weight of ~30.6 kDa.

HY-P76966

	USH1C Protein, Human (His) Harmonin; Antigen NY-Co-38/NY-Co-37; Protein PDZ-73; AIE75	Human	E. coli
	USH1C, an anchoring and scaffolding protein, is crucial for cochlear hair cell mechanotransduction. It forms a network with USH1G, CDH23, and MYO7A, contributing to the development and maintenance of hair cell bundles. As part of the intermicrovillar adhesion complex (IMAC), USH1C regulates brush border differentiation, influencing microvilli organization and length. It recruits CDHR2, CDHR5, and MYO7B to microvilli tips, participating in complexes like IMAC, USH1C/USH1G/MYO7A, and interacting with various proteins, highlighting its multifaceted role. USH1C Protein, Human (His) is the recombinant human-derived USH1C protein, expressed by E. coli, with N-6*His labeled tag. The total length of USH1C Protein, Human (His) is 552 a.a., with molecular weight of ~70 kDa.

HY-P71659

	USH1C Protein, Human (His-SUMO) AIE 75; AIE75; Antigen NY Co 38/NY Co 37; Deafness autosomal recessive 18; DFNB 18; DFNB18	Human	E. coli
	USH1C is an anchoring and scaffolding protein critical for cochlear hair cell mechanotransduction. It forms a network with USH1G, CDH23 and MYO7A and contributes to the development and maintenance of hair cell bundles. USH1C Protein, Human (His-SUMO) is the recombinant human-derived USH1C protein, expressed by E. coli , with N-His, N-SUMO labeled tag. The total length of USH1C Protein, Human (His-SUMO) is 533 a.a., with molecular weight of ~76.3 kDa.

HY-P75363

	CDC37 Protein, Mouse (sf9) Hsp90 Co-chaperone Cdc37; CDC37; CDC37A	Mouse	Sf9 insect cells
	CDC37 protein, a co-chaperone, binds to kinases and promotes their interaction with the Hsp90 complex, stabilizing and activating them. It inhibits HSP90AA1's ATPase activity. CDC37 likely forms a complex with HSP90, HSP70, STIP1/HOP, PPP5C, PTGES3/p23, TSC1, and TSC2. This complex may include CDK4, AKT, RAF1, and NR3C1 but lacks STIP1/HOP and PTGES3/p23. CDC37 also forms a separate complex with Hsp90/HSP90AB1 and CDK6. It interacts with HSP90AA1, AR, CDK4, CDK6, EIF2AK1, RB1, KSR1, FLCN, FNIP1, and FNIP2. CDC37 Protein, Mouse (sf9) is the recombinant mouse-derived CDC37 protein, expressed by Sf9 insect cells , with tag free. and with residual Gly-Pro in N-terminal (not related to functional changes) mutation. The total length of CDC37 Protein, Mouse (sf9) is 379 a.a., with molecular weight of ~46 kDa.

HY-P75364

	CDC37 Protein, Human (sf9, GST) Hsp90 Co-chaperone Cdc37; CDC37; CDC37A	Human	Sf9 insect cells
	The CDC37 protein is a co-chaperone that binds multiple kinases and promotes their interaction with the Hsp90 complex, resulting in stability and enhanced activity. CDC37 Protein, Human (sf9, GST) is the recombinant human-derived CDC37 protein, expressed by Sf9 insect cells , with C-GST labeled tag. The total length of CDC37 Protein, Human (sf9, GST) is 378 a.a., with molecular weight of ~70.7 kDa.

HY-P75362

	CDC37 Protein, Mouse (sf9, His-GST) Hsp90 Co-chaperone Cdc37; CDC37; CDC37A	Mouse	Sf9 insect cells
	The CDC37 protein is a co-chaperone that binds to kinases and promotes their interaction with Hsp90 complexes, thereby stabilizing and activating them. It inhibits the ATPase activity of HSP90AA1. CDC37 Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived CDC37 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of CDC37 Protein, Mouse (sf9, His-GST) is 379 a.a., with molecular weight of ~66 kDa.

HY-P72638

	Galectin-4/LGALS4 Protein, Human (His) Galectin-4; Gal-4; L36LBP; Antigen NY-Co-27; LGALS4	Human	E. coli
	Galectin-4/LGALS4 is a lactose-binding galectin protein with affinity for a variety of sugars. It is associated with the formation of adherens junctions, suggesting its potential role in cell adhesion processes. Galectin-4/LGALS4 Protein, Human (His) is the recombinant human-derived Galectin-4/LGALS4 protein, expressed by E. coli , with C-6*His labeled tag. The total length of Galectin-4/LGALS4 Protein, Human (His) is 323 a.a., with molecular weight of 35-38 kDa.

HY-P72638AF

	Animal-Free Galectin-4/LGALS4 Protein, Human (His) Galectin-4; Gal-4; L36LBP; Antigen NY-Co-27; LGALS4	Human	E. coli
	Galectin-4/LGALS4 is a lactose-binding galectin protein with affinity for a variety of sugars. It is associated with the formation of adherens junctions, suggesting its potential role in cell adhesion processes. Animal-Free Galectin-4/LGALS4 Protein, Human (His) is the recombinant human-derived animal-FreeGalectin-4/LGALS4 protein, expressed by E. coli , with N-His, N-His labeled tag. The total length of Animal-Free Galectin-4/LGALS4 Protein, Human (His) is 322 a.a., with molecular weight of ~36.8 kDa.

HY-P77778

	*HLA-A0201 P53 WT Protein, Human (HEK293, His-Avi)** MHC; HLA-A; P53; TP53; Antigen NY-Co-13; BCC7; FLJ92943; LFS1; TRP53	Human	HEK293
	HLA-A0201 MAGE-A4 Complex Protein, a member of the major histocompatibility complex (MHC) class I family, is highlighted. Additionally, the Chimeric HLA-A0201 WT-1 Complex Tetramer is recognized within the MHC class I family. HLA-A0201 P53 WT Protein, Human (HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived HLA-A0201 P53 WT protein, expressed by HEK293 , with C-Avi, C-His labeled tag. HLA-A*0201 P53 WT Protein, Human (HEK293, His-Avi), has molecular weight of 52-62 kDa.

HY-P77780

	*HLA-A0201 P53 WT Tetramer Protein, Human (HEK293, His-Avi)** MHC; HLA-A; P53; TP53; Antigen NY-Co-13; BCC7; FLJ92943; LFS1; TRP53	Human	HEK293
	HLA-A0201 MAGE-A4 Complex Protein, a member of the major histocompatibility complex (MHC) class I family, is highlighted. Additionally, the Chimeric HLA-A0201 WT-1 Complex Tetramer is recognized within the MHC class I family. HLA-A0201 P53 WT Tetramer Protein, Human (HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived HLA-A0201 P53 WT Tetramer protein, expressed by HEK293 , with C-Avi, C-His labeled tag. HLA-A*0201 P53 WT Tetramer Protein, Human (HEK293, His-Avi), has molecular weight of 260-265 kDa.

HY-P77779

	*HLA-A0201 P53 WT Complex Protein, Human (Biotinylated, HEK293, His-Avi)** MHC; HLA-A; P53; TP53; Antigen NY-Co-13; BCC7; FLJ92943; LFS1; TRP53	Human	HEK293
	HLA-A0201 MAGE-A4 Complex Protein, a member of the major histocompatibility complex (MHC) class I family, is highlighted. Additionally, the Chimeric HLA-A0201 WT-1 Complex Tetramer is recognized within the MHC class I family. HLA-A0201 P53 WT Complex Protein, Human (Biotinylated, HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived HLA-A0201 P53 WT Complex protein, expressed by HEK293 , with C-Avi, C-His labeled tag. HLA-A*0201 P53 WT Complex Protein, Human (Biotinylated, HEK293, His-Avi), has molecular weight of 51-60 kDa.

HY-P77775

	*HLA-A0201 P53 R175H Complex Protein, Human (HEK293, His-Avi)** MHC; HLA-A; P53; TP53; Antigen NY-Co-13; BCC7; FLJ92943; LFS1; TRP53	Human	HEK293
	HLA-A0201 MAGE-A4 Complex Protein, a member of the major histocompatibility complex (MHC) class I family, is highlighted. Additionally, the Chimeric HLA-A0201 WT-1 Complex Tetramer is recognized within the MHC class I family. HLA-A0201 P53 R175H Complex Protein, Human (HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived HLA-A0201 P53 R175H Complex protein, expressed by HEK293 , with C-Avi, C-His labeled tag. HLA-A*0201 P53 R175H Complex Protein, Human (HEK293, His-Avi), has molecular weight of 51-60 kDa.

HY-P77776

	*HLA-A0201 P53 R175H Complex Protein, Human (Biotinylated, HEK293, His-Avi)** MHC; HLA-A; P53; TP53; Antigen NY-Co-13; BCC7; FLJ92943; LFS1; TRP53	Human	HEK293
	HLA-A0201 MAGE-A4 Complex Protein, a member of the major histocompatibility complex (MHC) class I family, is highlighted. Additionally, the Chimeric HLA-A0201 WT-1 Complex Tetramer is recognized within the MHC class I family. HLA-A0201 P53 R175H Complex Protein, Human (Biotinylated, HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived HLA-A0201 P53 R175H Complex protein, expressed by HEK293 , with C-Avi, C-His labeled tag. HLA-A*0201 P53 R175H Complex Protein, Human (Biotinylated, HEK293, His-Avi), has molecular weight of 51-60 kDa.

HY-P77777

	*HLA-A0201 P53 R175H Complex Tetramer Protein, Human (HEK293, His-Avi)** MHC; HLA-A; P53; TP53; Antigen NY-Co-13; BCC7; FLJ92943; LFS1; TRP53	Human	HEK293
	HLA-A0201 MAGE-A4 Complex Protein, a member of the major histocompatibility complex (MHC) class I family, is highlighted. Additionally, the Chimeric HLA-A0201 WT-1 Complex Tetramer is recognized within the MHC class I family. HLA-A0201 P53 R175H Complex Tetramer Protein, Human (HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived HLA-A0201 P53 R175H Complex Tetramer protein, expressed by HEK293 , with C-Avi, C-His labeled tag. HLA-A*0201 P53 R175H Complex Tetramer Protein, Human (HEK293, His-Avi), has molecular weight of 260-265 kDa.

HY-P71340

	STUB1 Protein, Human E3 Ubiquitin-Protein Ligase CHIP; Antigen NY-Co-7; CLL-Associated Antigen KW-8; Carboxy Terminus of Hsp70-Interacting Protein; STIP1 Homology and U Box-Containing Protein 1; STUB1; CHIP	Human	E. coli
	STUB1 protein is an E3 ubiquitin protein ligase that cooperates with ATXN3 to regulate ubiquitin chain length on substrates and prevent chain extension. It ubiquitinates NOS1 through Hsp70/Hsp40 and regulates chaperone complexes (Hsp70, Hsc70, Hsp90). STUB1 Protein, Human is the recombinant human-derived STUB1 protein, expressed by E. coli , with tag free. The total length of STUB1 Protein, Human is 303 a.a., with molecular weight of ~33.0 kDa.

HY-P71662

	CD8 alpha Protein, Human (HEK293, His) p32; T cell antigen Leu2; T cell Co receptor; T-cell surface glyCoprotein CD8 alpha chain; T-lymphocyte differentiation antigen T8/Leu-2; T8 T cell antigen; T8/Leu-2 T-lymphocyte differentiation antigen	Human	HEK293
	CD8 alpha Protein is expressed on the surface of cytotoxic T cells. It plays a crucial role in immune responses by binding to major histocompatibility complex class I molecules on target cells, enhancing T cell activation and cytotoxicity. CD8 alpha Protein is also involved in immune regulation and tolerance. Understanding its functions can aid in developing immunotherapies and vaccines. CD8 alpha Protein, Human (HEK293, His) is the recombinant human-derived CD8 alpha protein, expressed by HEK293 , with N-6*His labeled tag. The total length of CD8 alpha Protein, Human (HEK293, His) is 161 a.a., with molecular weight of ~28 kDa.

Cat. No.	Product Name	Chemical Structure

HY-B0511S

Biotin-d2-1

Biotin-d₂-1 is the deuterium labeled Biotin. Biotin is an enzyme co-factor present in minute amounts in every living cell.
HY-B0511S1

rel-Biotin-d4

rel-Biotin-d₄ is the deuterium labeled Biotin. Biotin is an enzyme co-factor present in minute amounts in every living cell.

HY-Y0966S1

Glycine-d2
Glycine-d₂ is the deuterium labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.

HY-Y0966S8

Glycine-d5
Glycine-d₅ is the deuterium labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.

HY-B0511S2

Biotin-d2

Biotin-d₂ is the deuterium labeled Biotin. Biotin is an enzyme co-factor present in minute amounts in every living cell.

HY-Y0966S10

Glycine-d3
Glycine-d₃ is the deuterium labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.

HY-Y0966S3

Glycine-13C2
Glycine- ¹³C₂ is the ¹³C-labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.

HY-117727S

Leriglitazone-d4

Leriglitazone-d₄ (MIN-102-d₄; Hydroxypioglitazone-d₄) is deuterium labeled Leriglitazone. Leriglitazone (Hydroxypioglitazone), a metabolite of pioglitazone.Leriglitazone (Hydroxypioglitazone) PioOH is a PPARγ agonist, stabilizes the PPARγ activation function-2 (AF-2) co-activator binding surface and enhances co-activator binding, affording slightly better transcriptional efficacy.Leriglitazone (Hydroxypioglitazone) binds to the PPARγ C-terminal ligand-binding domain (LBD) with Ki of 1.2 μM，induces transcriptional efficacy of the PPARγ (LBD) with EC50 of 680 nM .

HY-Y0966S

Glycine-15N
Glycine- ¹⁵N is the ¹⁵N-labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors[1].

HY-Y0966S2

Glycine-2-13C
Glycine-2- ¹³C is the ¹³C-labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.

HY-Y0966S4

Glycine-1-13C
Glycine-1- ¹³C is the ¹³C-labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.

HY-Y0966S6

Glycine-13C2,15N
Glycine- ¹³C₂, ¹⁵N is the ¹³C- and ¹⁵N-labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.

HY-Y0966S9

Glycine-15N,d2
Glycine- ¹⁵N,d₂ is the deuterium and ¹⁵N-labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.

HY-Y0966S5

Glycine-1-13C,15N
Glycine-1- ¹³C, ¹⁵N is the ¹³C- and ¹⁵N-labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.

HY-Y0966S7

Glycine-2-13C,15N
Glycine-2- ¹³C, ¹⁵N is the ¹³C- and ¹⁵N-labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.

HY-100196S1

Pyrroloquinoline quinone-13C3 sodium
Pyrroloquinoline quinone-13C3 (sodium) is an isotope of Pyrroloquinoline quinone. Pyrroloquinoline quinone (PQQ), a redox co-factor, is an anionic, redox-cycling orthoquinone. Pyrroloquinoline quinone is isolated from cultures of methylotropic bacteria and tissues of mammals. Pyrroloquinoline quinone is an essential nutrient for mammals and is important for immune function .

HY-Y0966S11

Glycine-13C2,15N,d2
Glycine- ¹³C₂, ¹⁵N,d₂ is the deuterium, ¹³C and ¹⁵N labeled Glycine[1]. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors[2].

HY-101037S1

Sarcosine-d3
Sarcosine-d₃ is the deuterium labeled Sarcosine. Sarcosine (N-Methylglycine), an endogenous amino acid, is a competitive glycine transporter type I (GlyT1) inhibitor and N-methyl-D-aspartate (NMDA) receptor co-agonist. Sarcosine increases the glycine concentration, resulting in an indirect potentiation of the NMDA receptor. Sarcosine is commonly used for the research of schizophrenia[1][2].

HY-101037S

Sarcosine-15N
Sarcosine- ¹⁵N is the ¹⁵N-labeled Sarcosine. Sarcosine (N-Methylglycine), an endogenous amino acid, is a competitive glycine transporter type I (GlyT1) inhibitor and N-methyl-D-aspartate (NMDA) receptor co-agonist. Sarcosine increases the glycine concentration, resulting in an indirect potentiation of the NMDA receptor. Sarcosine is commonly used for the research of schizophrenia[1][2].

HY-B2246S

L-Carnitine-d9 chloride

L-Carnitine-d₉ (chloride)e is the deuterium labeled L-Carnitine chloride. L-Carnitine chloride, a highly polar, small zwitterion, is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine chloride functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine chloride is an antioxidant. L-Carnitine chloride can ameliorate metabolic imbalances in many inborn errors of metabolism[1][2][3].

HY-100808S

D-Serine-d3

D-Serine-d₃ ((R)-Serine-d₃) is a deuterium labeled D-Serine (HY-100808). D-Serine ((R)-Serine), an endogenous amino acid involved in glia-synapse interactions that has unique neurotransmitter characteristics, is a potent co-agonist at the NMDA glutamate receptor. D-Serinee has a cardinal modulatory role in major NMDAR-dependent processes including NMDAR-mediated neurotransmission, neurotoxicity, synaptic plasticity, and cell migration .

Cat. No.	Product Name	Application	Reactivity

HY-P83509

MTCO2 Antibody (YA3254)

MT-Co2; CoX2; Co2; Cytochrome c oxidase II; MTCo2; CoII; CoXII
WB, IHC-F, IHC-P, ICC/IF, IP Human

HY-P81048

Collagen VI Antibody (YA893) Alpha 1 (VI) chain (61 AA) antibody; Co6A1_HUMAN antibody; CoL6A1 antibody; Collagen alpha-1(VI) chain antibody; Collagen type VI alpha 1 antibody; Collagen VI alpha 1 polypeptide antibody; Collagen VI antibody; Human mRNA for Collagen VI alpha 2 C terminal globular domain antibody; OPLL antibody; PP3610 antibody	WB, IF-Cell, IF-Tissue, IHC-P	Human, Mouse, Rat
Collagen VI Antibody (YA893) is an unconjugated, approximately 109 kDa, rabbit-derived, anti-Collagen VI (YA893) monoclonal antibody. Collagen VI Antibody (YA893) can be used for: WB, IF-Cell, IF-Tissue, IHC-P expriments in human, mouse, rat background without labeling.

HY-P81227

Collagen I Antibody Collagen type I; Alpha 1 type I Collagen; Alpha 2 type I Collagen; CoL1A1; CoL1A2; Collagen I alpha 1 polypeptide; Collagen I alpha 2 polypeptide; Collagen Of Skin Tendon And Bone; Collagen Type 1; Collagen type I alpha 1; Collagen type I alpha 2; OI4; Osteogenesis Imperfecta Type IV; Pro alpha 1(I) Collagen; Type I proCollagen; Co1A1_HUMAN.	WB; ELISA; IHC-P; IHC-F; Flow-Cyt; IF	Human, Mouse, Rat, Rabbit(predicted: Chicken, Dog, Cow, Sheep)
Collagen I Antibody is an unconjugated, approximately 130 kDa, rabbit-derived, anti-Collagen I polyclonal antibody. Collagen I Antibody can be used for: WB, ELISA, IHC-P, IHC-F, Flow-Cyt, IF expriments in human, mouse, rat, rabbit, and predicted: chicken, dog, cow, sheep background without labeling.

HY-P81101

Collagen III Antibody CoL 3A1; CoL3A1; Collagen alpha 1(III) chain; Collagen III alpha 1 chain precursor; Collagen III alpha 1 polypeptide; Collagen type III alpha 1 (Ehlers Danlos syndrome type IV autosomal dominant); Collagen type III alpha 1; Collagen type III alpha; EDS4A; Ehlers Danlos syndrome type IV, autosomal dominant; Fetal Collagen; Type III Collagen; Co3A1_HUMAN; Collagen alpha-1(III) chain; Type III Collagen; type III preproCollagen alpha 1 chain.	WB; ELISA; IHC-P; IHC-F; IF	Human, Dog, Rabbit(predicted: Mouse, Rat, Chicken, Cow)
Collagen III Antibody is an unconjugated, approximately 117 kDa, rabbit-derived, anti-Collagen III polyclonal antibody. Collagen III Antibody can be used for: WB, ELISA, IHC-P, IHC-F, IF expriments in human, dog, rabbit, and predicted: mouse, rat, chicken, cow background without labeling.

HY-P81047

Collagen II Antibody Collagen II alpha 1; CoL2A1; CoL2A1 protein; Collagen, type II, alpha 1; Collagen alpha-1(II); type II Collagen; alpha-1 type II Collagen; alpha1 type II Collagen; Col2a1; AOM; Cartilage Collagen; Chondrocalcin; CoL11A3; Collagen alpha 1(II) chain precursor; Collagen II alpha 1 polypeptide; Collagen type II alpha 1 (primary osteoarthritis spondyloepiphyseal dysplasia Congenital); MGC131516; SEDC; Collagen alpha-1(II) chain; Alpha-1 type II Collagen; Co2A1_HUMAN.; CollagenII;	WB, ELISA, IHC-P, IF	Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Guinea Pig
Collagen II Antibody is an unconjugated, approximately 117 KDa, rabbit-derived, anti-Collagen II polyclonal antibody. Collagen II Antibody can be used for: WB, ELISA, IHC-P, IF expriments in human, mouse, rat, chicken, dog, pig, cow, rabbit, guinea pig background without labeling.

HY-P81201

Collagen IV Antibody Arresten; Canstatin; CoL4A1; HANAC; ICH; POREN1; Collagen Alpha 1(IV) Chain; Collagen IV Alpha 1 Polypeptide; Collagen Of Basement Membrane Alpha 1 Chain; Collagen Of Basement Membrane Alpha 2 Chain; Collagen Type IV Alpha 1; DKFZp686I14213; FLJ22259; Collagen alpha-1(IV) chain preproprotein; Collagen alpha-1(IV) chain preproprotein; Col4a1 protein; Collagen of basement membrane, alpha-1 chain; Collagen IV, alpha-1 polypeptide; Collagen alpha-1(IV) chain; CoL4A1 NC1 domain; Co4A1_HUMAN; Collagen Ⅳ; Collagen Type Ⅳ.	ELISA; IHC-P; IHC-F; Flow-Cyt; IF	Human, Mouse, Rat(predicted: Chicken, Dog, Pig, Cow, Horse, Rabbit)
Collagen IV Antibody is an unconjugated, approximately 165 kDa, rabbit-derived, anti-Collagen IV polyclonal antibody. Collagen IV Antibody can be used for: ELISA, IHC-P, IHC-F, Flow-Cyt, IF expriments in human, mouse, rat, and predicted: chicken, dog, pig, cow, horse, rabbit background without labeling.

HY-P82351

STUB1 Antibody (YA2096)

STUB1; CHIP; HSPABP2; NY-Co-7; SDCCAG7; UBOX1
WB, ICC/IF, IP Human, Mouse, Rat

HY-P80938

p53 Antibody TP53; P53; Cellular tumor antigen p53; Antigen NY-Co-13; Phosphoprotein p53; Tumor suppressor p53	WB, IHC, IF, ELISA	Human, Mouse, Rat, Monkey
p53 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 44 kDa, targeting to p53 tumor protein. It can be used for WB,IHC,IF, ELISA assays in the background of Human, Mouse, Rat, Monkey.

HY-P80843

Phospho-p53 (Ser37) Antibody 1 Publications Verification TP53; P53; Cellular tumor antigen p53; Antigen NY-Co-13; Phosphoprotein p53; Tumor suppressor p53	WB, ICC/IF	Human, Mouse, Rat
Phospho-p53 (Ser37) Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 44 kDa, targeting to Phospho-p53 (Ser37). It can be used for WB,ICC/IF assays with tag free, in the background of Human, Mouse, Rat.

HY-P80844

Phospho-p53 (Ser6) Antibody TP53; P53; Cellular tumor antigen p53; Antigen NY-Co-13; Phosphoprotein p53; Tumor suppressor p53	WB, IHC-P, IP	Human
Phospho-p53 (Ser6) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 44 kDa, targeting to Phospho-p53 (Ser6). It can be used for WB,IHC-P,IP assays with tag free, in the background of Human.

HY-P82868

Hsp110 Antibody (YA2613)

Antigen NY-Co-25; Heat shock protein 105 kDa; HS105; HSP105; HSP105A; HSP105B; HSP110; HSPH1
WB, IHC-P, ICC/IF, IP Human, Mouse, Rat

HY-P81286

LYRIC Antibody (YA995) MTDH; AEG1; LYRIC; Protein LYRIC; 3D3/LYRIC; Astrocyte elevated gene-1 protein; AEG-1; Lysine-rich CEACAM1 Co-isolated protein; Metadherin; Metastasis adhesion protein	WB, IHC-P, FC	Human

HY-P81286A

LYRIC Antibody (YA996) MTDH; AEG1; LYRIC; Protein LYRIC; 3D3/LYRIC; Astrocyte elevated gene-1 protein; AEG-1; Lysine-rich CEACAM1 Co-isolated protein; Metadherin; Metastasis adhesion protein	WB, IHC-F, IHC-P, ICC/IF, IP	Human

HY-P83319

ICOS Ligand Antibody (YA3064)

inducible T-cell Co-stimulator ligand; B7H2; GL50; B7-H2; B7RP1; CD275; ICoSL; LICoS; B7RP-1; ICoS-L
WB, IP Human

HY-P83386

p23 Antibody (YA3131) PTGES3; P23; TEBP; Prostaglandin E synthase 3; Cytosolic prostaglandin E2 synthase; cPGES; Hsp90 Co-chaperone; Progesterone receptor Complex p23; Telomerase-binding protein p23	WB, ICC/IF, IP	Human, Mouse, Rat

HY-P81706

B7H2 Antibody (YA1451)

inducible T-cell Co-stimulator ligand; B7H2; GL50; B7-H2; B7RP1; CD275; ICoSL; LICoS; B7RP-1; ICoS-L
FC, ELISA Human

HY-P81748

Cytokeratin 15 Antibody (YA1493) CK-15; CK15; cytokeratin15; K15; K1C15; K1Co; keratin 15; Keratin-15; keratin-15; beta; KRT15; KRTB; type I cytoskeletal 15	WB, IHC-P, ICC/IF, FC	Human, Mouse

HY-P81148

CD8 Antibody CD8 antigen, alpha polypeptide (p32); CD8a; CD8a antigen; CD8a molecule; CD8A_MOUSE; CD8A_HUMAN; Leu2; Leu2 T lymphocyte antigen; MAL; OKT8 T cell antigen; p32; T cell antigen Leu2; T cell Co receptor; T-cell surface glyCoprotein CD8 alpha chain; T-lymphocyte differentiation antigen T8/Leu-2; T8 T cell antigen.	WB; IHC-P; IHC-F; IF	Human, Mouse,
CD8 Antibody is an unconjugated, approximately 27 kDa, rabbit-derived, anti-CD8 polyclonal antibody. CD8 Antibody can be used for: WB, IHC-P, IHC-F, IF expriments in human, mouse, background without labeling.

Cat. No.	Product Name		Classification

HY-108369

Azido-PEG1-CH2CO2H		Azide PROTAC Synthesis
Azido-PEG1-CH2CO2H is a PROTAC linker, which refers to the alkyl/ether composition. Azido-PEG1-CH2CO2H can be used in the synthesis of PROTAC BRD4 Degrader-1 . Azido-PEG1-CH2CO2H is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-130194

Azido-PEG5-CH2CO2H		PROTAC Synthesis Azide ADC Synthesis
Azido-PEG5-CH2CO2H is a cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG5-CH2CO2H is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG5-CH2CO2H is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-140766

Azido-PEG5-CH2CO2-NHS		PROTAC Synthesis Azide
Azido-PEG5-CH2CO2-NHS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG5-CH2CO2-NHS is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-160077

Pomalidomide-CO-C5-azide		Azide
Pomalidomide-CO-C5-azide (Compound PA) is a ligand for E3 ligase bearing a bioorthogonal group azide. Pomalidomide-CO-C5-azide can be used to synthesize PROTACs with anticancer activity .

HY-140763

Azido-PEG1-CH2CO2-NHS		PROTAC Synthesis Azide
Azido-PEG1-CH2CO2-NHS is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG1-CH2CO2-NHS is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-140853

Azido-PEG3-CH2CO2Me		PROTAC Synthesis Azide
Azido-PEG3-CH2CO2Me is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG3-CH2CO2Me is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-138350

Azido-PEG10-CH2CO2-NHS		Azide PROTAC Synthesis
Azido-PEG10-CH2CO2-NHS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG10-CH2CO2-NHS is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-130693

Azido-PEG5-CH2CO2-PFP		Azide PROTAC Synthesis
Azido-PEG5-CH2CO2-PFP is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs . Azido-PEG5-CH2CO2-PFP is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-140349

AZD-CO-C2-Ph-amido-Ph-azide		PROTAC Synthesis Azide
AZD-CO-C2-Ph-amido-Ph-azide is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs . AZD-CO-C2-Ph-amido-Ph-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-157407

Cyclooctyne-O-amido-PEG4-VC-PAB-Gly-Gly-NH-O-CO-Exatecan

Alkynes

Cyclooctyne-O-amido-PEG4-VC-PAB-Gly-Gly-NH-O-CO-Exatecan is a drug-linker conjugate for ADC (ADC Cytotoxin: Exatecan) .

HY-133736

PROTAC BRD4 Degrader-5-CO-PEG3-N3		Azide
PROTAC BRD4 Degrader-5-CO-PEG3-N3 (Compound 2) is a PROTAC-linker Conjugate for PAC, comprises the BRD4 degrader GNE-987 and PEG-based linker . PROTAC BRD4 Degrader-5-CO-PEG3-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-151824

Boc-L-Phe(4-NH-Poc)-OH		Alkynes
Boc-L-Phe(4-NH-Poc)-OH is a click chemistry reagent containing an azide group. Used as an orthogonally protected building block in peptide synthesis. Propargyloxycarbonyl, commonly abbreviated as Poc or Pryoc, can either be used as alkyne component for standard Click conjugation or in combination with tetrazine linkers in copper-free Diels-Alder type Click reactions. It also has applications as unusual protecting group for amines, hydroxy functions and as esters. All 3 are stable to neat TFA, but can be cleaved at ambient temperature with Co2(CO)8 in TFA:DCM. Deprotection with other transition metals like palladium have also been reported . Boc-L-Phe(4-NH-Poc)-OH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-151837

H-L-Phe(4-NH-Poc)-OH hydrochloride		Alkynes
H-L-Phe(4-NH-Poc)-OH (hydrochloride) is a click chemistry reagent containing an azide group. Used as a modified Phe or Tyr analogue in protein and peptide biosynthesis. Propargyloxycarbonyl, commonly abbreviated as Poc or Pryoc, can either be used as alkyne component for standard Click conjugation or in combination with tetrazine linkers in copper-free Diels-Alder type Click reactions. It also has applications as unusual protecting group for amines, hydroxy functions and as esters. All 3 are stable to neat TFA, but can be cleaved at ambient temperature with Co2(CO)8 in TFA:DCM. Deprotection with other transition metals like palladium have also been reported . H-L-Phe(4-NH-Poc)-OH (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-147206A

Biotin-PEG-Alk (MW 1000)		Alkynes
Biotin-PEG-Alk (MW 1000) is a biotin labeled PEG derivative. Biotin is an enzyme co-factor, can be used for labeling protein; PEG is a hydrophilic and water-soluble polymer with low toxicity; Alk (Alkyne), acyclic (branched or unbranched) aliphatic hydrocarbon, can react with azido, which improve the efficiency of biotin binding targets. Biotin-PEG-Alk (MW 1000) is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-147206B

Biotin-PEG-Alk (MW 2000)		Alkynes
Biotin-PEG-Alk (MW 2000) is a biotin labeled PEG derivative. Biotin is an enzyme co-factor, can be used for labeling protein; PEG is a hydrophilic and water-soluble polymer with low toxicity; Alk (Alkyne), acyclic (branched or unbranched) aliphatic hydrocarbon, can react with azido, which improve the efficiency of biotin binding targets. Biotin-PEG-Alk (MW 2000) is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-147206C

Biotin-PEG-Alk (MW 3400)		Alkynes
Biotin-PEG-Alk (MW 3400) is a biotin labeled PEG derivative. Biotin is an enzyme co-factor, can be used for labeling protein; PEG is a hydrophilic and water-soluble polymer with low toxicity; Alk (Alkyne), acyclic (branched or unbranched) aliphatic hydrocarbon, can react with azido, which improve the efficiency of biotin binding targets. Biotin-PEG-Alk (MW 3400) is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-147206E

Biotin-PEG-Alk (MW 10000)		Alkynes
Biotin-PEG-Alk (MW 10000) is a biotin labeled PEG derivative. Biotin is an enzyme co-factor, can be used for labeling protein; PEG is a hydrophilic and water-soluble polymer with low toxicity; Alk (Alkyne), acyclic (branched or unbranched) aliphatic hydrocarbon, can react with azido, which improve the efficiency of biotin binding targets. Biotin-PEG-Alk (MW 10000) is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-147206F

Biotin-PEG-Alk (MW 20000)		Alkynes
Biotin-PEG-Alk (MW 20000) is a biotin labeled PEG derivative. Biotin is an enzyme co-factor, can be used for labeling protein; PEG is a hydrophilic and water-soluble polymer with low toxicity; Alk (Alkyne), acyclic (branched or unbranched) aliphatic hydrocarbon, can react with azido, which improve the efficiency of biotin binding targets. Biotin-PEG-Alk (MW 20000) is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.


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Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

MCE Kits

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Co

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

MCE Kits

Inhibitory Antibodies

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Natural
Products