Hydroxypropyl Cellulose

Name: Hydroxypropyl Cellulose
Brand: MedChemExpress
SKU: HY-100557
Rating: 4.5 (1 reviews)

Cat. No.: HY-100557 Purity: 97.0%: Data Sheet
COA

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Hydroxypropyl Cellulose is an orally active cellulose ether and surfactant. Hydroxypropyl cellulose is divided into high-substituted HPC (HHPC) and low-substituted HPC (LHPC). Hydroxypropyl Cellulose reduces inflammatory mediators (IL-6, IL-1β). Hydroxypropyl Cellulose improves colitis and obesity. Hydroxypropyl Cellulose can be used as a pharmaceutical excipient, such as coating agent, emulsifier, suspension, tablet, thickener, viscosifier.

For research use only. We do not sell to patients.

Hydroxypropyl Cellulose Chemical Structure

CAS No. : 9004-64-2

Size	Stock	Quantity
10 g	In-stock	Estimated Time of Arrival: December 31
25 g	In-stock	Estimated Time of Arrival: December 31
50 g	In-stock	Estimated Time of Arrival: December 31
100 g	In-stock	Estimated Time of Arrival: December 31
500 g	Get quote	Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Hydroxypropyl Cellulose:

HPC, Viscosity(1%):150-400mPa.s Get quote
HPC, Viscosity(1%):4000-6500mPa.s Get quote
HPC, Viscosity(5%):75-150mPa.s Get quote
HPC, Viscosity(1%):1275-3500mPa.s Get quote
HPC, Viscosity(2%):95000-105000mPa.s Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Hydroxypropyl methylcellulose (HHPC; 12.5-1600 μg/mL; 24 h) promotes the growth of RAW 264.7 cells and inhibits inflammation^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Hydroxypropyl methylcellulose (150-300 mg/kg; p.o.; 8 days) ameliorates DSS-induced colitis in Balb/c mice^[3].
Hydroxypropyl methylcellulose (6% in diet; p.o.; 5 weeks) ameliorates the effects of a high-fat diet on intestinal permeability, insulin resistance, hepatic lipid accumulation, glucocorticoid related bile acid recycling, oxidative stress, and weight gain in DIO mice^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Balb/c male mice (DSS-induced colitis model)^[3]
Dosage:	150 mg/kg, 300 mg/kg (suspended in water)
Administration:	Oral administration, 8 days
Result:	Mitigated the pathological damage of colon tissue. Suppressed spleen edema, preserved thymus index, reduced the serum level of inflammatory mediators (TNF-α, IL-6, IL-1β, and MPO). Increased the secretion of sIgA in the colon, and restored the balance of the intestinal flora.

CAS No.

9004-64-2

Appearance

Solid

Color

White to off-white

SMILES

CO[C@H]1C(O[R])[C@@H](O[R])[C@H](C)O[C@@H]1CO[R].[n].[R=H or CH2CH(OH)CH3]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature 3 years

In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

H₂O : 50 mg/mL (Need ultrasonic)

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

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Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 97.0%

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Data Sheet (278 KB) SDS (394 KB)

COA (255 KB) HNMR (117 KB)

Handling Instructions (2659 KB)

References

[1]. Werbowyj R S, et al. Liquid crystalline structure in aqueous hydroxypropyl cellulose solutions[J]. Molecular Crystals and Liquid Crystals, 1976, 34(4): 97-103.

[2]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99. [Content Brief]

[3]. Li X, et al. The potential therapeutic effects of hydroxypropyl cellulose on acute murine colitis induced by DSS. Carbohydr Polym. 2022 Aug 1;289:119430. [Content Brief]

[4]. Kim H, et al. Altered hepatic gene expression profiles associated with improved fatty liver, insulin resistance, and intestinal permeability after hydroxypropyl methylcellulose (HPMC) supplementation in diet-induced obese mice. J Agric Food Chem. 2013 Jul 3;61(26):6404-11. [Content Brief]