Hydroxypropyl Cellulose
Based on 1 Customer Validation
Hydroxypropyl Cellulose is an orally active cellulose ether and surfactant. Hydroxypropyl cellulose is divided into high-substituted HPC (HHPC) and low-substituted HPC (LHPC). Hydroxypropyl Cellulose reduces inflammatory mediators (IL-6, IL-1β). Hydroxypropyl Cellulose improves colitis and obesity. Hydroxypropyl Cellulose can be used as a pharmaceutical excipient, such as coating agent, emulsifier, suspension, tablet, thickener, viscosifier.
For research use only. We do not sell to patients.
- CAS No.: 9004-64-2
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Storage:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Hydroxypropyl methylcellulose (HHPC; 12.5-1600 μg/mL; 24 h) promotes the growth of RAW 264.7 cells and inhibits inflammation[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Hydroxypropyl methylcellulose (6% in diet; p.o.; 5 weeks) ameliorates the effects of a high-fat diet on intestinal permeability, insulin resistance, hepatic lipid accumulation, glucocorticoid related bile acid recycling, oxidative stress, and weight gain in DIO mice[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Balb/c male mice (DSS-induced colitis model)[3]
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Dosage:150 mg/kg, 300 mg/kg (suspended in water)
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Administration:Oral administration, 8 days
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Result:Mitigated the pathological damage of colon tissue.
Suppressed spleen edema, preserved thymus index, reduced the serum level of inflammatory mediators (TNF-α, IL-6, IL-1β, and MPO).
Increased the secretion of sIgA in the colon, and restored the balance of the intestinal flora.
Chemical Information
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CAS No. 9004-64-2
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Appearance Solid
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Color White to off-white
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SMILES
CO[C@H]1C(O[R])[C@@H](O[R])[C@H](C)O[C@@H]1CO[R].[n].[R=H or CH2CH(OH)CH3]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
H2O : 50 mg/mL (Need ultrasonic)
Purity & Documentation
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Data Sheet (278 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[2]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99. [Content Brief]
[3]. Li X, et al. The potential therapeutic effects of hydroxypropyl cellulose on acute murine colitis induced by DSS. Carbohydr Polym. 2022 Aug 1;289:119430. [Content Brief]
[4]. Kim H, et al. Altered hepatic gene expression profiles associated with improved fatty liver, insulin resistance, and intestinal permeability after hydroxypropyl methylcellulose (HPMC) supplementation in diet-induced obese mice. J Agric Food Chem. 2013 Jul 3;61(26):6404-11. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Hydroxypropyl Cellulose Related Classifications
Cat. No.: HY-100557
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- Hydroxypropyl Cellulose
- 9004-64-2
- Environmental Pollutants
- Interleukin Related
- Biochemical Assay Reagents
- pharmaceutical excipient
- pharmaceutical auxiliarie
- pharmaceutical ingredients
- inactive ingredients
- stability
- solubility
- processability
- absorption
- distribution
- metabolism
- and elimination (ADME)
- Inhibitor
- inhibitor
- inhibit