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  3. CO23

CO23 

Cat. No.: HY-130012
Handling Instructions

CO23 is a selective thyroid hormone receptor (TR) α agonist and used for growth and development regulation. CO23 was able to be transported through the blood-brain barrier.

For research use only. We do not sell to patients.

CO23 Chemical Structure

CO23 Chemical Structure

CAS No. : 1370363-74-8

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Description

CO23 is a selective thyroid hormone receptor (TR) α agonist and used for growth and development regulation. CO23 was able to be transported through the blood-brain barrier[1].

IC50 & Target

TRα[1]

In Vivo

CO23 (ip; 0.04-5.0 nmol/g) has ≈50% cholesterol reduction with 0.8 nmol/g dose and higher doses are equally effective. CO23 has no effect at the lowest dose of 0.04 nmol/g and increases Dio1 mRNA 5-, 10-, and 15-fold at the doses of 0.8, 2.5, and 5 nmol/g, respectively[1].

Animal Model: Hypothyroid Wistar rats[1]
Dosage: 0.04, 0.8, 2.5, and 5.0 nmol/g
Administration: Ip
Result: Had ≈50% cholesterol reduction with 0.8 nmol/g dose and higher doses were equally effective.
Molecular Weight

592.17

Formula

C₁₉H₁₈I₂N₂O₄

CAS No.

1370363-74-8

SMILES

O=C1NC(C(CC2=CC(I)=C(OC3=CC=C(O)C(C(C)C)=C3)C(I)=C2)N1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

CO23CO 23CO-23Thyroid Hormone ReceptorTHRInhibitorinhibitorinhibit

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