2. Vitamin D Related/Nuclear Receptor
  3. Thyroid Hormone Receptor
  4. CO23

CO23 is a selective thyroid hormone receptor (TR) α agonist and used for growth and development regulation. CO23 was able to be transported through the blood-brain barrier.

For research use only. We do not sell to patients.

CO23 Chemical Structure

CO23 Chemical Structure

CAS No. : 1370363-74-8

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10 mg USD 1450 In-stock
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Based on 1 publication(s) in Google Scholar

CO23 Related Antibodies

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Description

CO23 is a selective thyroid hormone receptor (TR) α agonist and used for growth and development regulation. CO23 was able to be transported through the blood-brain barrier[1].

IC50 & Target

TRα[1]
In Vivo

CO23 (ip; 0.04-5.0 nmol/g) has ≈50% cholesterol reduction with 0.8 nmol/g dose and higher doses are equally effective. CO23 has no effect at the lowest dose of 0.04 nmol/g and increases Dio1 mRNA 5-, 10-, and 15-fold at the doses of 0.8, 2.5, and 5 nmol/g, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Hypothyroid Wistar rats[1]
Dosage: 0.04, 0.8, 2.5, and 5.0 nmol/g
Administration: Ip
Result: Had ≈50% cholesterol reduction with 0.8 nmol/g dose and higher doses were equally effective.
Molecular Weight

592.17

Formula

C19H18I2N2O4
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C1NC(C(CC2=CC(I)=C(OC3=CC=C(O)C(C(C)C)=C3)C(I)=C2)N1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (422.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6887 mL 8.4435 mL 16.8870 mL
5 mM 0.3377 mL 1.6887 mL 3.3774 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6887 mL 8.4435 mL 16.8870 mL 42.2176 mL
5 mM 0.3377 mL 1.6887 mL 3.3774 mL 8.4435 mL
10 mM 0.1689 mL 0.8444 mL 1.6887 mL 4.2218 mL
15 mM 0.1126 mL 0.5629 mL 1.1258 mL 2.8145 mL
20 mM 0.0844 mL 0.4222 mL 0.8444 mL 2.1109 mL
25 mM 0.0675 mL 0.3377 mL 0.6755 mL 1.6887 mL
30 mM 0.0563 mL 0.2815 mL 0.5629 mL 1.4073 mL
40 mM 0.0422 mL 0.2111 mL 0.4222 mL 1.0554 mL
50 mM 0.0338 mL 0.1689 mL 0.3377 mL 0.8444 mL
60 mM 0.0281 mL 0.1407 mL 0.2815 mL 0.7036 mL
80 mM 0.0211 mL 0.1055 mL 0.2111 mL 0.5277 mL
100 mM 0.0169 mL 0.0844 mL 0.1689 mL 0.4222 mL
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CO23 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CO231370363-74-8CO 23CO-23Thyroid Hormone ReceptorTHRInhibitorinhibitorinhibit

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