CO23
Based on 1 publication(s) in Google Scholar
CO23 is a selective thyroid hormone receptor (TR) α agonist and used for growth and development regulation.
For research use only. We do not sell to patients.
- Purity: 98.00%
- CAS No.: 1370363-74-8
- Formula: C19H18I2N2O4
- Molecular Weight:592.17
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) CO23
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Biological Activity
TRα[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | EC50 |
11 nM
Compound: CO23
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Effect on human TRalpha transactivation activity in HeLa cells by luciferase reporter assay
Effect on human TRalpha transactivation activity in HeLa cells by luciferase reporter assay
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[PMID: 17988877] |
| HeLa | EC50 |
58 nM
Compound: CO23
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Effect on human TRbeta transactivation activity in HeLa cells by luciferase reporter assay
Effect on human TRbeta transactivation activity in HeLa cells by luciferase reporter assay
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[PMID: 17988877] |
| U2OS | EC50 |
34 nM
Compound: CO23
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Effect on human TRalpha transactivation activity in U2OS cells by luciferase reporter assay
Effect on human TRalpha transactivation activity in U2OS cells by luciferase reporter assay
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[PMID: 17988877] |
| U2OS | EC50 |
390 nM
Compound: CO23
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Effect on human TRbeta transactivation activity in U2OS cells by luciferase reporter assay
Effect on human TRbeta transactivation activity in U2OS cells by luciferase reporter assay
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[PMID: 17988877] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Hypothyroid Wistar rats[1]
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Dosage:0.04, 0.8, 2.5, and 5.0 nmol/g
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Administration:Ip
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Result:Had ≈50% cholesterol reduction with 0.8 nmol/g dose and higher doses were equally effective.
Chemical Information
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CAS No. 1370363-74-8
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Appearance Solid
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Molecular Weight 592.17
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Formula C19H18I2N2O4
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Color Off-white to light yellow
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SMILES
O=C1NC(C(CC2=CC(I)=C(OC3=CC=C(O)C(C(C)C)=C3)C(I)=C2)N1)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Drug Metab Dispos
Metabolic flux analysis of bile acid biosynthesis acidic pathway in HepG2 cells reveals CYP8B1 inhibition of azole antifungals. [Abstract]2025 Nov;53(11):100168. PMID: 41124962
Solvent & Solubility
DMSO : 250 mg/mL (422.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6887 mL | 8.4435 mL | 16.8870 mL | 42.2176 mL |
| 5 mM | 0.3377 mL | 1.6887 mL | 3.3774 mL | 8.4435 mL | |
| 10 mM | 0.1689 mL | 0.8444 mL | 1.6887 mL | 4.2218 mL | |
| 15 mM | 0.1126 mL | 0.5629 mL | 1.1258 mL | 2.8145 mL | |
| 20 mM | 0.0844 mL | 0.4222 mL | 0.8444 mL | 2.1109 mL | |
| 25 mM | 0.0675 mL | 0.3377 mL | 0.6755 mL | 1.6887 mL | |
| 30 mM | 0.0563 mL | 0.2815 mL | 0.5629 mL | 1.4073 mL | |
| 40 mM | 0.0422 mL | 0.2111 mL | 0.4222 mL | 1.0554 mL | |
| 50 mM | 0.0338 mL | 0.1689 mL | 0.3377 mL | 0.8444 mL | |
| 60 mM | 0.0281 mL | 0.1407 mL | 0.2815 mL | 0.7036 mL | |
| 80 mM | 0.0211 mL | 0.1055 mL | 0.2111 mL | 0.5277 mL | |
| 100 mM | 0.0169 mL | 0.0844 mL | 0.1689 mL | 0.4222 mL |
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