Pyrene-1,3,6,8-tetrasulfonic acid tetrasodium
Based on 1 Customer Validation
Pyrene-1,3,6,8-tetrasulfonic acid tetrasodium is a fluorescent dye and pH indicator, also as a ligand of multifunctional metal-organic framework. Pyrene-1,3,6,8-tetrasulfonic acid tetrasodium has been used to detect CO2 release. Pyrene-1,3,6,8-tetrasulfonic acid tetrasodium acts as a water-soluble fluorescent dye for fluorescence quenching assays monitoring gramicidin ion-channel activity. Ex/Em = 396/404 nm.
For research use only. We do not sell to patients.
- Purity : 99.0%
- CAS No.: 59572-10-0
- Formula: C16H6Na4O12S4
- Molecular Weight:610.43
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
In Vitro
Pyrene-1,3,6,8-tetrasulfonic acid (4.16 mM; 90-100 min) enables detection of preserved gramicidin ion-channel activity in sol-gel immobilized EyPC LUVs, as shown by a KSV of 1.03 that matches the free vesicle system[2].
Pyrene-1,3,6,8-tetrasulfonic acid (4.16 mM; 90-100 min) enables detection of preserved gramicidin ion-channel activity in sol-gel immobilized EyPG LUVs, as shown by a KSV of 1.23[2].
Pyrene-1,3,6,8-tetrasulfonic acid exhibits consistent long fluorescence mean-lifetimes across acidic, neutral, and basic aqueous solutions, with measured values of 13.0 ns (pH 4), 12.4 ns (pH ~7), and 12.4 ns (pH 10)[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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CAS No. 59572-10-0
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Appearance Solid
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Molecular Weight 610.43
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Formula C16H6Na4O12S4
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Color Light yellow to yellow
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SMILES
[Na].O=S(=O)(O)C1=CC(=C2C=CC=3C=4C(=CC=C1C24)C(=CC3S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
H2O : 100 mg/mL (163.82 mM; Need ultrasonic)
DMSO : 2 mg/mL (3.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (281 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Wang XB, et al. Probing the electronic stability of multiply charged anions: sulfonated pyrene tri- and tetraanions. J Am Chem Soc. 2009;131(28):9836-9842. [Content Brief]
[2]. Esquembre R, et al. Biophysical and functional characterization of an ion channel peptide confined in a sol-gel matrix. J Phys Chem B. 2009;113(21):7534-7540. [Content Brief]
[3]. Zhang, J. Rational designed of graphene dispersant. 30 Nov 2016
[4]. Boni L, et al. Fluorescence Mean-Lifetimes of a Series of Small and Bright Fluorescent Dyes. Luminescence. 2026;41(1):e70392. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 1.6382 mL | 8.1909 mL | 16.3819 mL | 40.9547 mL |
| H2O | 5 mM | 0.3276 mL | 1.6382 mL | 3.2764 mL | 8.1909 mL |
| 10 mM | 0.1638 mL | 0.8191 mL | 1.6382 mL | 4.0955 mL | |
| 15 mM | 0.1092 mL | 0.5461 mL | 1.0921 mL | 2.7303 mL | |
| 20 mM | 0.0819 mL | 0.4095 mL | 0.8191 mL | 2.0477 mL | |
| 25 mM | 0.0655 mL | 0.3276 mL | 0.6553 mL | 1.6382 mL | |
| 30 mM | 0.0546 mL | 0.2730 mL | 0.5461 mL | 1.3652 mL | |
| 40 mM | 0.0410 mL | 0.2048 mL | 0.4095 mL | 1.0239 mL | |
| 50 mM | 0.0328 mL | 0.1638 mL | 0.3276 mL | 0.8191 mL | |
| 60 mM | 0.0273 mL | 0.1365 mL | 0.2730 mL | 0.6826 mL | |
| 80 mM | 0.0205 mL | 0.1024 mL | 0.2048 mL | 0.5119 mL | |
| 100 mM | 0.0164 mL | 0.0819 mL | 0.1638 mL | 0.4095 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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