Poloxamer 183 (L63)  (Synonyms: PEG-PPG-PEG, 2650 (Average))

Poloxamer 183 L63 is a block copolymer of polyoxyethylene and polyoxypropylene with an average molecular weight of 2000. Poloxamer has the ability to inhibit P-gp. Poloxamer 183 exhibits antimicrobial activity and can inhibit Mycobacterium avium. Poloxamer 183 can be used as a cosmetic ingredient^[1][2].

Poloxamer 183 (1 mg/mL) can inhibit 80% of Mycobacterium avium^[1].
Poloxamer has the ability to inhibit P-gp^[2].
Poloxamer has been proposed as an agent carrier to improve agent efficacy and reduce side effects^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2650 (Average)

9003-11-6

[Poloxamer 183 (L63)]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Singh-Joy SD, et al., Safety assessment of poloxamers 101, 105, 108, 122, 123, 124, 181, 182, 183, 184, 185, 188, 212, 215, 217, 231, 234, 235, 237, 238, 282, 284, 288, 331, 333, 334, 335, 338, 401, 402, 403, and 407, poloxamer 105 benzoate, and poloxamer 182 dibenzoate as used in cosmetics. Int J Toxicol. 2008;27 Suppl 2:93-128.  [Content Brief]

  [2]. Hunter RL, et al., Enhancement of antibiotic susceptibility and suppression of Mycobacterium avium complex growth by poloxamer 331. antimicrob Agents Chemother. 1995 Feb;39(2):435-9.  [Content Brief]

  [3]. Mello JC, et al. Enhancement of chlorpromazine antitumor activity by Pluronics F127/L81 nanostructured system against human multidrug resistant leukemia. Pharmacol Res. 2016 Sep;111:102-112.  [Content Brief]