DL-Penicillamine (Synonyms: (±)-Penicillamine)

Cat. No.: HY-W017457 Purity: 99.10%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

DL-Penicillamine [(±)-Penicillamine] is a copper chelating agent. DL-Penicillamine has antidotal effects in thallotoxicosis rats when co-treated with Prussian blue (HY-106594A). DL-Penicillamine can cause pyridoxine deficiency and then induce optic axial neuritis. DL-Penicillamine can also depress primary immune response.

For research use only. We do not sell to patients.

DL-Penicillamine Chemical Structure

CAS No. : 52-66-4

Size	Price	Stock	Quantity
Solid + Solvent
10 mM * 1 mL in DMSO ready for reconstitution	USD 44	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 44	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 25	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 40	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 87	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 130	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 195	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

Other Forms of DL-Penicillamine:

Penicillamine In-stock
Penicillamine-d₃ Get quote

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Purity & Documentation
References
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Description

In Vivo

DL-Penicillamine (25 mg/kg; i.p.; twice daily, for 5 days) has antidotal effects in thallotoxicosis rats when co-treated with Prussian blue (HY-106594A)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Wistar rats, NIH strain (intoxicated by i.p. injection of 32 mg/kg thallium (I) acetate)^[2]
Dosage:	25 mg/kg
Administration:	i.p.; twice daily, for 5 days
Result:	Decreased slightly the thallium content in blood, organs and brain. Increased the probability survival when co-treated with Prussian blue (50 mg/kg; p.o.).

Molecular Weight

149.21

Formula

C₅H₁₁NO₂S

CAS No.

52-66-4

Appearance

Solid

SMILES

CC(C(N)C(O)=O)(S)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

H₂O : 33.33 mg/mL (223.38 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.7020 mL	33.5098 mL	67.0196 mL
5 mM	1.3404 mL	6.7020 mL	13.4039 mL
10 mM	0.6702 mL	3.3510 mL	6.7020 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.10%

Select Batch:

Data Sheet (272 KB) SDS (0 KB)

COA (246 KB) HNMR (112 KB) LCMS (234 KB)

Handling Instructions (2659 KB)

References

[1]. TU J, BLACKWELL RQ, LEE PF. DL-penicillamine as a cause of optic axial neuritis. JAMA. 1963 Jul 13;185:83-6. [Content Brief]

[2]. Montes S, et al. Additive effect of DL-penicillamine plus Prussian blue for the antidotal treatment of thallotoxicosis in rats. Environ Toxicol Pharmacol. 2011 Nov;32(3):349-55. [Content Brief]

[3]. Huebner Kf, Gengozian N. Depression Of The Primary Immune Response By Dl-Penicillamine. Proc Soc Exp Biol Med. 1965 Feb;118:561-5. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	6.7020 mL	33.5098 mL	67.0196 mL	167.5491 mL
	5 mM	1.3404 mL	6.7020 mL	13.4039 mL	33.5098 mL
	10 mM	0.6702 mL	3.3510 mL	6.7020 mL	16.7549 mL
	15 mM	0.4468 mL	2.2340 mL	4.4680 mL	11.1699 mL
	20 mM	0.3351 mL	1.6755 mL	3.3510 mL	8.3775 mL
	25 mM	0.2681 mL	1.3404 mL	2.6808 mL	6.7020 mL
	30 mM	0.2234 mL	1.1170 mL	2.2340 mL	5.5850 mL
	40 mM	0.1675 mL	0.8377 mL	1.6755 mL	4.1887 mL
	50 mM	0.1340 mL	0.6702 mL	1.3404 mL	3.3510 mL
	60 mM	0.1117 mL	0.5585 mL	1.1170 mL	2.7925 mL
	80 mM	0.0838 mL	0.4189 mL	0.8377 mL	2.0944 mL
	100 mM	0.0670 mL	0.3351 mL	0.6702 mL	1.6755 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

DL-Penicillamine Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DL-Penicillamine52-66-4(±)-PenicillamineOtherscopperchelatingthalliumPrussian blueInhibitorinhibitorinhibit

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