52-66-4
52-66-4
Chemical Structure
DL-Penicillamine
Synonym(s): (±)-Penicillamine
- CAS No.: 52-66-4
- Formula:C5H11NO2S
- Molecular Weight:149.22
IUPAC Name: 2-amino-3-mercapto-3-methylbutanoic acid
InChIKey: VVNCNSJFMMFHPL-UHFFFAOYSA-N
SMILES: CC(C(N)C(O)=O)(S)C
Biological Activity: DL-Penicillamine [(±)-Penicillamine] is a copper chelating agent. DL-Penicillamine has antidotal effects in thallotoxicosis rats when co-treated with Prussian blue (HY-106594A). DL-Penicillamine can cause pyridoxine deficiency and then induce optic axial neuritis. DL-Penicillamine can also depress primary immune response[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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DL-Penicillamine | 98.0% | DL-Penicillamine [(±)-Penicillamine] is a copper chelating agent. DL-Penicillamine has antidotal effects in thallotoxicosis rats when co-treated with Prussian blue (HY-106594A). DL-Penicillamine can cause pyridoxine deficiency and then induce optic axial neuritis. DL-Penicillamine can also depress primary immune response. | ||||||||||||||||||||
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DL-Penicillamine (Standard) | ≥98% | DL-Penicillamine (Standard) is the analytical standard of DL-Penicillamine. This product is intended for research and analytical applications. DL-Penicillamine [(±)-Penicillamine] is a copper chelating agent. DL-Penicillamine has antidotal effects in thallotoxicosis rats when co-treated with Prussian blue (HY-106594A). DL-Penicillamine can cause pyridoxine deficiency and then induce optic axial neuritis. DL-Penicillamine can also depress primary immune response. | ||||||||||||||||||||
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L-Penicillamine | 99.71% | L-Penicillamine is an orally active serine palmitoyltransferase (SPT) inhibitor. L-Penicillamine inactivates the PLP cofactor by forming adducts, thereby inhibiting SPT activity and reducing sphingolipid biosynthesis. L-Penicillamine not only blocks tumor access to vitamin B6, but also stabilizes the human papillomavirus 16 E6 oncoprotein monomer and inhibits its polymerization, exhibiting a unique anticancer mechanism. L-Penicillamine effectively delays the growth of Sarcoma-180, induces tumor necrosis and prolongs survival (though long-term use may lead to Pyridoxine (HY-B1328) deficiency and weight loss). | ||||||||||||||||||||
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L-Valine-d1 | L-Valine-d is the deuterium labeled L-Valine (HY-N0717). L-Valine ((S)-Valine) is a nonlinear semiorganic material. L-Valine causes lipid peroxidation and accumulation of malondialdehyde (MDA), exhibits inhibitory activity against cyanobacteria. L-Valine inhibits multidrug-resistant bacteria through activation of PI3K/Akt signaling pathway and inhibition of arginase. | |||||||||||||||||||||
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(S)-2-Amino-3,3-dimethylbutanoic acid | 98.0% | (S)-2-amino-3,3-dimethylbutanoic acid is a leucine derivative. | ||||||||||||||||||||
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4-Methyl-L-leucine | 97.0% | 4-Methyl-L-leucine is a Glycine (HY-Y0966) derivative. | ||||||||||||||||||||
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Penicillamine (Standard) | ≥98% | Penicillamine (Standard) is the analytical standard of Penicillamine. This product is intended for research and analytical applications. Penicillamine (D-(-)-Penicillamine) is a penicillin metabolic degradation product, can be used as a heavy metal chelator. Penicillamine increases free copper and increases oxidative stress. Penicillamine has effect of seizures through nitric oxide/NMDA pathways. Penicillamine is a potential immune modulator. Penicillamine can be used for the research of Wilson disease, rheumatoid arthritis, and cystinuria. | ||||||||||||||||||||
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D-a-tert-Butyl-Gly-OH | 98.0% | D-a-tert-Butyl-Gly-OH is a leucine derivative. | ||||||||||||||||||||
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2-Amino-3,3-dimethylbutanoic acid | 98.0% | 2-Amino-3,3-dimethylbutanoic acid is a leucine derivative. | ||||||||||||||||||||
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DL-Valine-d-1 | DL-Valine-d-1 is the deuterium labeled DL-Valine. | |||||||||||||||||||||
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3-Fluoro-DL-valine | 3-Fluoro-DL-valine (3-Fluorovaline) is an unnatural amino acid that has the activity of inhibiting the growth of certain bacteria. 3-Fluoro-DL-valine can also be used in peptide synthesis, providing a variety of options for the synthesis of specific bioactive peptides. The unique structure of 3-Fluoro-DL-valine makes it a potential application prospect in compound research and development. | |||||||||||||||||||||
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S-Methyl-D-penicillamine | S-Methyl-D-penicillamine is a metabolite of the chelating agent Penicillamine (HY-B0300). | |||||||||||||||||||||
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References
- [1]. TU J, BLACKWELL RQ, LEE PF. DL-penicillamine as a cause of optic axial neuritis. JAMA. 1963 Jul 13;185:83-6. [Content Brief]
- [2]. Montes S, et al. Additive effect of DL-penicillamine plus Prussian blue for the antidotal treatment of thallotoxicosis in rats. Environ Toxicol Pharmacol. 2011 Nov;32(3):349-55. [Content Brief]
- [3]. Huebner Kf, Gengozian N. Depression Of The Primary Immune Response By Dl-Penicillamine. Proc Soc Exp Biol Med. 1965 Feb;118:561-5. [Content Brief]
