Art. -Nr.: HY-123011

Henagliflozin

(Synonyms: SHR3824)

Kundenbewertung

Based on 1 Customer Validation

Henagliflozin (SHR3824) is a potent selective sodium-glucose co-transporter 2 (SGLT2) inhibitor with the IC₅₀ values of 2.38 and 4324 nM for human SGLT2 and SGLT1, respectively. Henagliflozin can be used in diabetes research.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit: 98.05%
CAS. Nr.: 1623804-44-3
Formel: C₂₂H₂₄ClFO₇
Molecular Weight:454.87

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Henagliflozin Chemical Structure

CAS. Nr.: 1623804-44-3

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vivo
- Clinical Trial
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

SGLT2

Alle SGLT Isoform-spezifische Produkte anzeigen :

SGLT1
SGLT2

In Vivo

Henagliflozin (SHR3824) (p.o., 0.1-3.0 mg/kg, once) improves glucose tolerance in a dose-dependent manner in normal mice after exposure to glucose challenge^[1].
Henagliflozin (SHR3824) (p.o., 0.3-3.0 mg/kg, once daily, 41 days) increases urinary glucose excretion in a dose-dependent manner and significantly reduces blood glucose levels in GK rats, with no effect on body weight or food intake. The HbA1c values of GK rats treated with 0.3, 1.0 or 3.0 mg/kg are 5.47%, 5.19% and 5.04%, respectively^[1].
Henagliflozin (SHR3824) (p.o., 0.3-3.0 mg/kg, once daily, 43 days) causes a dose-dependent increase in urinary output and urinary glucose excretion in db/db mice, with a concomitant decrease in plasma glucose levels and no effect on body weight or food intake. The doses of 0.3, 1.0 or 3.0 mg/kg results in significant reductions in non-fasting and fasting glucose levels of 24.7%, 28.2% or 35.1% and 49.5%, 57.8% or 62.9%, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 1623804-44-3
Appearance Solid
Molecular Weight 454.87
Formel C₂₂H₂₄ClFO₇
Color White to off-white
SMILES

O[C@H]1[C@@]2(C3=CC(CC4=CC(F)=C(C=C4)OCC)=C(C=C3)Cl)O[C@](CO2)([C@H]([C@@H]1O)O)CO
Synonyms

SHR3824
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (219.84 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.1984 mL

10.9922 mL

21.9843 mL

5 mM

0.4397 mL

2.1984 mL

4.3969 mL

10 mM

0.2198 mL

1.0992 mL

2.1984 mL

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (5.50 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (5.50 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (5.50 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (281 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Pang-ke Yan, et al. SHR3824, a novel selective inhibitor of renal sodium glucose cotransporter 2, exhibits antidiabetic efficacy in rodent models. Acta Pharmacol Sin. 2014 May;35(5):613-24. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.1984 mL	10.9922 mL	21.9843 mL	54.9608 mL
	5 mM	0.4397 mL	2.1984 mL	4.3969 mL	10.9922 mL
	10 mM	0.2198 mL	1.0992 mL	2.1984 mL	5.4961 mL
	15 mM	0.1466 mL	0.7328 mL	1.4656 mL	3.6641 mL
	20 mM	0.1099 mL	0.5496 mL	1.0992 mL	2.7480 mL
	25 mM	0.0879 mL	0.4397 mL	0.8794 mL	2.1984 mL
	30 mM	0.0733 mL	0.3664 mL	0.7328 mL	1.8320 mL
	40 mM	0.0550 mL	0.2748 mL	0.5496 mL	1.3740 mL
	50 mM	0.0440 mL	0.2198 mL	0.4397 mL	1.0992 mL
	60 mM	0.0366 mL	0.1832 mL	0.3664 mL	0.9160 mL
	80 mM	0.0275 mL	0.1374 mL	0.2748 mL	0.6870 mL
	100 mM	0.0220 mL	0.1099 mL	0.2198 mL	0.5496 mL

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Henagliflozin

Anti-diabetic Compound Library

Anti-Cancer Metabolism Compound Library

Anti-Obesity Compound Library

Human Metabolite Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Highly Selective Inhibitors Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Drug Repurposing Compound Library Plus

Clinical Compound Library Plus

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Mass Spectrometry Human Metabolite Library

Membrane Transporter/Ion Channel Compound Library

Clinical Compound Library

Drug Repurposing Compound Library

Alle SGLT Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Henagliflozin

Anti-diabetic Compound Library

Anti-Cancer Metabolism Compound Library

Anti-Obesity Compound Library

Human Metabolite Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Highly Selective Inhibitors Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Drug Repurposing Compound Library Plus

Clinical Compound Library Plus

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Mass Spectrometry Human Metabolite Library

Membrane Transporter/Ion Channel Compound Library

Clinical Compound Library

Drug Repurposing Compound Library

Alle SGLT Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Henagliflozin Related Classifications

HY-123011 Related Classifications