1. GPCR/G Protein
  2. LPL Receptor
  3. CYM-5520

CYM-5520 

Cat. No.: HY-100953 Purity: 99.79%
Handling Instructions

CYM-5520 is a selective and allosteric sphingosine 1-phosphate receptor 2 (S1PR2) agonist with an EC50 of 480 nM. CYM-5520 does not activate S1PR1, S1PR3, S1PR4 and S1PR5 receptors. CYM-5520 can co-bind in the S1PR2 receptor with S1P. CYM-5520 can be used for osteoporosis research.

For research use only. We do not sell to patients.

CYM-5520 Chemical Structure

CYM-5520 Chemical Structure

CAS No. : 1449747-00-5

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 130 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 130 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 118 In-stock
Estimated Time of Arrival: December 31
10 mg USD 178 In-stock
Estimated Time of Arrival: December 31
25 mg USD 320 In-stock
Estimated Time of Arrival: December 31
50 mg USD 480 In-stock
Estimated Time of Arrival: December 31
100 mg USD 720 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

CYM-5520 is a selective and allosteric sphingosine 1-phosphate receptor 2 (S1PR2) agonist with an EC50 of 480 nM. CYM-5520 does not activate S1PR1, S1PR3, S1PR4 and S1PR5 receptors. CYM-5520 can co-bind in the S1PR2 receptor with S1P. CYM-5520 can be used for osteoporosis research[1][2].

In Vitro

CYM-5520 (EC50 of 1.6 μM) is a full agonist for wild type S1PR2. Stimulation of cells expressing the triple mutant S1PR2 with S1P does not elicit a rise in luciferase activity, whereas the CYM-5520 is an agonist with an EC50 of 1.5 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CYM-5520 (10 mg/kg; i.p.; 5 consecutive days per week; for 6 weeks) treatment clearly increases long bone and vertebral bone mass in osteopenic ovariectomized mice. CYM-5520 also increases osteoblast number, osteoid surface and alkaline phosphatase, and plasma concentrations of the osteoanabolic marker procollagen I C-terminal propeptide are also elevated[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Ovariectomized 12 weeks old C57Bl6J mice[2]
Dosage: 10 mg/kg
Administration: i.p.; 5 consecutive days per week; for 6 weeks
Result: Corrected ovariectomy-induced osteopenia in mice by inducing new bone formation.
Molecular Weight

345.39

Formula

C₂₁H₁₉N₃O₂

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (144.76 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8953 mL 14.4764 mL 28.9528 mL
5 mM 0.5791 mL 2.8953 mL 5.7906 mL
10 mM 0.2895 mL 1.4476 mL 2.8953 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.24 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
CYM-5520
Cat. No.:
HY-100953
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