1. GPCR/G Protein
  2. GPCR19
  3. TGR5 Receptor Agonist

TGR5 Receptor Agonist (Synonyms: CCDC)

Cat. No.: HY-14229 Purity: 99.85%
Handling Instructions

TGR5 Receptor Agonist (CCDC), a potent TGR5(GPCR19) agonist, shows improved potency in the U2-OS cell assay (pEC50=6.8) and in melanophore cells (pEC50=7.5).

For research use only. We do not sell to patients.

TGR5 Receptor Agonist Chemical Structure

TGR5 Receptor Agonist Chemical Structure

CAS No. : 1197300-24-5

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 99 In-stock
Estimated Time of Arrival: December 31
5 mg USD 90 In-stock
Estimated Time of Arrival: December 31
10 mg USD 150 In-stock
Estimated Time of Arrival: December 31
50 mg USD 530 In-stock
Estimated Time of Arrival: December 31
100 mg USD 940 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

TGR5 Receptor Agonist (CCDC), a potent TGR5(GPCR19) agonist, shows improved potency in the U2-OS cell assay (pEC50=6.8) and in melanophore cells (pEC50=7.5)[1].

IC50 & Target

IC50 value: 6.8 (pEC50, U2-OS cell assay); 7.5 (pEC50, melanophore cell)[1]

Molecular Weight

361.22

Formula

C₁₈H₁₄Cl₂N₂O₂

CAS No.

1197300-24-5

SMILES

ClC1=CC=CC=C1C2=NOC(C)=C2C(N(C)C3=CC=C(Cl)C=C3)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 48 mg/mL (132.88 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7684 mL 13.8420 mL 27.6840 mL
5 mM 0.5537 mL 2.7684 mL 5.5368 mL
10 mM 0.2768 mL 1.3842 mL 2.7684 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 10 mg/mL (27.68 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 10 mg/mL (27.68 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

TGR5 Receptor AgonistCCDCGPCR19G-protein coupled receptor 19Inhibitorinhibitorinhibit

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Product Name:
TGR5 Receptor Agonist
Cat. No.:
HY-14229
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