1. GPCR/G Protein
  2. LPL Receptor
  3. GLPG2938

GLPG2938 

Cat. No.: HY-139310
Handling Instructions

GLPG2938 is a potent and selective S1P2 antagonist. GLPG2938 can be used for the research of idiopathic pulmonary fibrosis.

For research use only. We do not sell to patients.

GLPG2938 Chemical Structure

GLPG2938 Chemical Structure

CAS No. : 2130996-00-6

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 221 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 200 In-stock
Estimated Time of Arrival: December 31
10 mg USD 350 In-stock
Estimated Time of Arrival: December 31
25 mg USD 700 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1200 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1750 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

GLPG2938 is a potent and selective S1P2 antagonist. GLPG2938 can be used for the research of idiopathic pulmonary fibrosis[1].

IC50 & Target[1]

S1PR2

 

In Vitro

GLPG2938 (0.5~5 μM; HPF cells) significantly prevents the S1P-mediated contraction at all tested concentrations[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

GLPG2938 (1~10 mg/kg; p.o.) displays a marked protective effect at all dosed tested, resulting in statistically significant reduction of the Ashcroft score[1].
GLPG2938 shows good pharmacokinetics, with long half-life, low clearance, and good bioavailability in all species, especially in dogs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6 mice[1]
Dosage: 1~10 mg/kg
Administration: P.o.
Result: Displayed a marked protective effect at all dosed tested, resulting in statistically significant reduction of the Ashcroft score.  
Molecular Weight

503.40

Formula

C₂₀H₁₉F₆N₇O₂

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
References
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Product Name:
GLPG2938
Cat. No.:
HY-139310
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