2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Pyrroloquinoline quinone disodium salt

Pyrroloquinoline quinone disodium salt  (Synonyms: PQQ disodium salt; Methoxatin disodium salt)

Cat. No.: HY-100196A Purity: 98.0%
COA
SDS
Handling Instructions Technical Support

Pyrroloquinoline quinone disodium salt, a redox co-factor, is an anionic, redox-cycling orthoquinone. Pyrroloquinoline quinone disodium salt is isolated from cultures of methylotropic bacteria and tissues of mammals. Pyrroloquinoline quinone disodium salt is an essential nutrient for mammals and is important for immune function.

For research use only. We do not sell to patients.

CAS No. : 122628-50-6

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Based on 7 publication(s) in Google Scholar

Other Forms of Pyrroloquinoline quinone disodium salt:

Pyrroloquinoline quinone disodium salt Related Antibodies

Top Publications Citing Use of Products

    Pyrroloquinoline quinone disodium salt purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2026 Apr:153:157996.

    Cell viability of human articular chondrocytes (HACs) after 24 or 48 h treatment with Pyrroloquinoline quinone (PQQ, 1–100 μM).

    Pyrroloquinoline quinone disodium salt purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2026 Apr:153:157996.

    Western blotting and densitometric quantification of Lamin B1, P16, CDKN1A (P21) and MMP13 in indicated groups. The results showed that Pyrroloquinoline quinone (PQQ, 4 mg/kg; chow diet; 12 months) restored Lamin B1 levels while suppressing P16, P21 and MMP13 proteins in aged joint tissues.

    Pyrroloquinoline quinone disodium salt purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2026 Apr:153:157996.

    12‑month‑old wild-type (WT) male mice were given standard chow or Pyrroloquinoline quinone (PQQ)‑enriched chow (4 mg/kg) for 12 months and analyzed at 24 months (n = 6). Representative Safranin O–Fast Green (SO‑FG) staining of knee cartilage. The results showed that PQQ markedly improved cartilage integrity in 24-month-old mice.

    Pyrroloquinoline quinone disodium salt purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2026 Apr:153:157996.

    12‑month‑old wild-type (WT) male mice were given standard chow or Pyrroloquinoline quinone (PQQ)‑enriched chow (4 mg/kg) for 12 months and analyzed at 24 months (n = 6). Micro-CT analysis demonstrated that PQQ decreased bone volume (BV) of the calcified meniscus and synovial tissue in aged mice, indicating preserved joint architecture.

    Pyrroloquinoline quinone disodium salt purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2026 Apr:153:157996.

    Representative immunostaining of knee joint sections from 12‑month, 24‑month and Pyrroloquinoline quinone (PQQ, 4 mg/kg; chow diet; 12 months)‑treated 24‑month mice for 8‑hydroxy‑2′‑deoxyguanosine (8‑OHdG), cyclin‑dependent kinase inhibitor 2A (P16), IL‑1β, interleukin‑6 (IL‑6), COL2A1 and MMP13.

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    Human Endogenous Metabolite Microbial Metabolite

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Pyrroloquinoline quinone disodium salt, a redox co-factor, is an anionic, redox-cycling orthoquinone. Pyrroloquinoline quinone disodium salt is isolated from cultures of methylotropic bacteria and tissues of mammals. Pyrroloquinoline quinone disodium salt is an essential nutrient for mammals and is important for immune function[1][2].

    IC50 & Target[1]

    Microbial Metabolite

     

    Human Endogenous Metabolite

     

    In Vitro

    Mouse pups born to and nursing from Pyrroloquinoline quinone disodium salt-deprived dams have a compromised immune response as well as alopecia, a hunched posture, and a susceptibility to aortic aneurysms[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Pyrroloquinoline quinone disodium salt Related Antibodies
    Molecular Weight

    374.17

    Formula

    C14H4N2Na2O8
    CAS No.
    Appearance

    Solid

    Color

    Pink to red

    SMILES

    O=C(C(N1)=CC(C2=O)=C1C3=C(N=C(C(O[Na])=O)C=C3C(O)=O)C2=O)O[Na]
    Structure Classification
    Initial Source

    Guinea-pig neutrophils
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    0.5 M NaOH : 10 mg/mL (26.73 mM; Need ultrasonic)

    H2O : 1.25 mg/mL (3.34 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.6726 mL 13.3629 mL 26.7258 mL
    5 mM 0.5345 mL 2.6726 mL 5.3452 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

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    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 2 mg/mL (5.35 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

    • Protocol 2

      Add each solvent one by one:  0.5% CMC-Na/saline water

      Solubility: 5 mg/mL (13.36 mM); Suspended solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 98.0%

    SDS (393 KB)

    COA (255 KB) HNMR (253 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O / 0.5 M NaOH 1 mM 2.6726 mL 13.3629 mL 26.7258 mL 66.8145 mL
    0.5 M NaOH 5 mM 0.5345 mL 2.6726 mL 5.3452 mL 13.3629 mL
    10 mM 0.2673 mL 1.3363 mL 2.6726 mL 6.6815 mL
    15 mM 0.1782 mL 0.8909 mL 1.7817 mL 4.4543 mL
    20 mM 0.1336 mL 0.6681 mL 1.3363 mL 3.3407 mL
    25 mM 0.1069 mL 0.5345 mL 1.0690 mL 2.6726 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Pyrroloquinoline quinone disodium salt Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Pyrroloquinoline quinone disodium122628-50-6PQQ disodium Methoxatin disodiumEndogenous Metaboliteredoxco-factoranionicmethylotropicbacteriaessentialnutrientimmunefunctionInhibitorinhibitorinhibit

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