Evidence for methoxatin (pyrroloquinolinequinone) as the cofactor in bovine plasma amine oxidase from resonance Raman spectroscopy

  • Proc Natl Acad Sci U S A. 1986 Nov;83(22):8435-9. doi: 10.1073/pnas.83.22.8435.
R S Moog ,  M A McGuirl ,  C E Cote ,  D M Dooley
PMID: 3464962 DOI: 10.1073/pnas.83.22.8435
Abstract

Resonance Raman spectra of the 2,4-dinitrophenylhydrazine derivatives of bovine plasma amine oxidase [amine:oxygen oxidoreductase (deaminating) (copper-containing), EC 1.4.3.6] have been measured. Detailed comparisons to the spectra of the corresponding derivatives of methoxatin (pyrroloquinolinequinone), pyridoxal, and Other aldehydes and diones provide further evidence that covalently bound methoxatin or a closely similar derivative is the organic cofactor in copper-containing amine oxidases.

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