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PLGA (Synonyms: poly(lactic-co-glycolic acid))

Cat. No.: HY-B2247 Purity: ≥99.0%
Handling Instructions

PLGA is a copolymer of poly lactic acid (PLA) and poly glycolic acid (PGA) which can be used to fabricate devices for drug delivery and tissue engineering applications.

For research use only. We do not sell to patients.

PLGA Chemical Structure

PLGA Chemical Structure

CAS No. : 34346-01-5

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Free Sample (0.5-1 mg)   Apply Now  
500 mg USD 65 In-stock
Estimated Time of Arrival: December 31
1 g USD 110 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 5 publication(s) in Google Scholar

Top Publications Citing Use of Products

    PLGA purchased from MCE. Usage Cited in: Biomed Pharmacother. 2020 Sep;129:110371.

    Immunofluorescence staining displays weaker Bcl-2 fluorescence intensity in lung cancer cells incubated with RBCm-Obatoclax Mesylate (OM)/PLGA, accompanied with stronger expression of pro-apoptotic signal Bax in comparison to the Con group.

    PLGA purchased from MCE. Usage Cited in: Biomed Pharmacother. 2020 Sep;129:110371.

    Bcl-2 and Bcl-xl protein expression levels are restrained in A549 and H1975 cells treated with RBCm-OM/PLGA; however, Bax, cleaved Caspase-3, Caspase-9 and PARP are up-regulated following RBCm-OM/PLGA incubation. Also, free Obatoclax Mesylate (OM) does not influence the expression change of all these proteins.
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    PLGA is a copolymer of poly lactic acid (PLA) and poly glycolic acid (PGA) which can be used to fabricate devices for drug delivery and tissue engineering applications.

    Clinical Trial
    Molecular Weight

    10000-20000

    CAS No.
    SMILES

    O=C(O)C(C)OC(CO[H])=O.[x].[y]

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 75 mg/mL (Need ultrasonic)

    H2O : < 0.1 mg/mL (insoluble)

    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: 3.75 mg/mL (Infinity mM); Suspended solution; Need ultrasonic

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 3.75 mg/mL (Infinity mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 3.75 mg/mL (Infinity mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References

    Purity: ≥99.0%

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    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Keywords:

    PLGApoly(lactic-co-glycolic acid)OthersInhibitorinhibitorinhibit

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    Product Name:
    PLGA
    Cat. No.:
    HY-B2247
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