USH1C Protein, Human (His)

USH1C, an anchoring and scaffolding protein, is crucial for cochlear hair cell mechanotransduction. It forms a network with USH1G, CDH23, and MYO7A, contributing to the development and maintenance of hair cell bundles. As part of the intermicrovillar adhesion complex (IMAC), USH1C regulates brush border differentiation, influencing microvilli organization and length. It recruits CDHR2, CDHR5, and MYO7B to microvilli tips, participating in complexes like IMAC, USH1C/USH1G/MYO7A, and interacting with various proteins, highlighting its multifaceted role. USH1C Protein, Human (His) is the recombinant human-derived USH1C protein, expressed by E. coli, with N-6*His labeled tag. The total length of USH1C Protein, Human (His) is 552 a.a., with molecular weight of ~70 kDa.

USH1C, an anchoring and scaffolding protein, plays a crucial role in the mechanotransduction process within cochlear hair cells, forming an intricate network with USH1G, CDH23, and MYO7A. It is essential for the normal development and maintenance of cochlear hair cell bundles. As a component of the intermicrovillar adhesion complex (IMAC), USH1C contributes to brush border differentiation, exerting control over microvilli organization and length. Its regulatory significance is evident in the assembly of the complex, where it recruits CDHR2, CDHR5, and MYO7B to the tips of microvilli. USH1C participates in various complexes, including IMAC and the complex composed of USH1C, USH1G, and MYO7A. Its interactions extend to F-actin, USH2A, SLC4A7, USHBP1, CDH23, USH1G, MYO7B, CDHR2, CDHR5, and ANKS4B, emphasizing its multifaceted role in cellular processes and protein associations.

Data is not available.

Human

E. coli

N-6*His

Q9Y6N9 (M1-F552)

10083  [NCBI]

MDRKVAREFRHKVDFLIENDAEKDYLYDVLRMYHQTMDVAVLVGDLKLVINEPSRLPLFDAIRPLIPLKHQVEYDQLTPRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKGGQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPLTWQYVDQFVSESGGVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKPGIFISHVKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIVAAAGRELFMTDRERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRKEMEQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPKYDQGVEPELEPADDLDGGTEEQGEQDFRKYEEGFDPYSMFTPEQIMGKDVRLLRIKKEGSLDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVKGDEIMAINGKIVTDYTLAEAEAALQKAWNQGGDWIDLVVAVCPPKEYDDELTFF

Approximately 70 kDa

• 
  Greater than 95% as determined by reducing SDS-PAGE

Solution.

Supplied as a 0.2 μm filtered solution of 50 mM Tris, 300 mM NaCl, pH 7.4, 20% Glycerol.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.