Polyoxyl 40 stearate
Based on 1 Customer Validation
Polyoxyl 40 stearate (PEG 40 stearate) is a nonionic surfactant formed by the esterification of stearic acid with polyethylene glycol (PEG) containing approximately 40 ethoxy units, it is widely used in pharmaceutical preparations, nanodrug carriers, emulsification systems and biomedical materials. Polyoxyl 40 stearate can serve as a matrix component of solid lipid nanoparticles to achieve controlled release of encapsulated antifungal drugs; it can also act as a base material for solid lipid nanoparticles for vaginal administration, and polymerizable groups can be introduced via modification with acryloyl chloride.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 171286-89-8
- Formula: C98H196O42
- Molecular Weight:2046.58
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Polyoxyl 40 stearate can serve as a matrix component of solid lipid nanoparticles to achieve controlled release of encapsulated antifungal agents; it can also act as a base material for solid lipid nanoparticles for vaginal administration, and polymerizable groups can be introduced via modification with acryloyl chloride[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 171286-89-8
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Appearance Solid
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Molecular Weight 2046.58
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Formula C98H196O42
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Color White to off-white
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SMILES
O=C(OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO)CCCCCCCCCCCCCCCCC
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Synonyms
PEG 40 stearate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 175 mg/mL (85.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
[1]. Owen J, et al. The Role of PEG-40-stearate in the Production, Morphology, and Stability of Microbubbles. Langmuir. 2019 Aug 6;35(31):10014-10024. [Content Brief]
[2]. Cassano R, et al. Preparation, characterization and in vitro activities evaluation of solid lipid nanoparticles based on PEG-40 stearate for antifungal drugs vaginal delivery. Drug Deliv. 2016;23(3):1047-56. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.4886 mL | 2.4431 mL | 4.8862 mL | 12.2155 mL |
| 5 mM | 0.0977 mL | 0.4886 mL | 0.9772 mL | 2.4431 mL | |
| 10 mM | 0.0489 mL | 0.2443 mL | 0.4886 mL | 1.2216 mL | |
| 15 mM | 0.0326 mL | 0.1629 mL | 0.3257 mL | 0.8144 mL | |
| 20 mM | 0.0244 mL | 0.1222 mL | 0.2443 mL | 0.6108 mL | |
| 25 mM | 0.0195 mL | 0.0977 mL | 0.1954 mL | 0.4886 mL | |
| 30 mM | 0.0163 mL | 0.0814 mL | 0.1629 mL | 0.4072 mL | |
| 40 mM | 0.0122 mL | 0.0611 mL | 0.1222 mL | 0.3054 mL | |
| 50 mM | 0.0098 mL | 0.0489 mL | 0.0977 mL | 0.2443 mL | |
| 60 mM | 0.0081 mL | 0.0407 mL | 0.0814 mL | 0.2036 mL | |
| 80 mM | 0.0061 mL | 0.0305 mL | 0.0611 mL | 0.1527 mL |
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