Cobalt protoporphyrin IX
Cobalt protoporphyrin IX (Co-PPIX) is a potent and specific heme oxygenase-1 (HO-1) inducer. Cobalt protoporphyrin IX exhibits broad-spectrum antiviral activities against Influenza A virus (IAV).
For research use only. We do not sell to patients.
- CAS No.: 14325-03-2
- Formula: C34H32CoN4O4
- Molecular Weight:619.58
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Cobalt protoporphyrin IX (2 μM; 0-24 h) increases the intracellular protein levels of HO-1 in a time-dependent manner in MDCK cells and RAW264.7 cells[1].
Cobalt protoporphyrin IX shows antiviral activity against influenza viruses with IC50s of 0.40 ± 0.16, 0.42 ± 0.15, 0.46 ± 0.19, 0.34 ± 0.05 and 0.64 ± 0.30 μM against Empty Cell A/FortMonmouth /1/1947, A/TianjinJinnan /15/2009, A/Wuhan /359/1995, A/FujianTongan /196/2009 and BY/FujianXinluo /54/2006, respectively[1].
Cobalt protoporphyrin IX (0.25-2 μM; 18 or 24 h) inhibits IAV replication through augmenting IFN response, and the anti-IAV activity is not dependent on the catalytic function of HO-1[1].
Anti-IAV activity of HO-1 induced by Cobalt protoporphyrin IX (2 μM; 0-6 h) may depend on IRF3 phosphorylation and translocation, in order to enhance antiviral IFN response[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDCK cells and RAW264.7 cells
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Concentration:2 μM
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Incubation Time:0, 3, 6, 12 and 24 h
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Result:Significantly increased the intracellular protein levels of HO-1 in a time-dependent manner in MDCK cells and RAW264.7 cells.
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Cell Line:RAW264.7 cells were infected with IAV A/Fort Monmouth/1/1947 (0.2 MOI)
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Concentration:0.25, 0.5, 1 and 2 μM
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Incubation Time:18 h
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Result:Enhanced mRNA expressions of IFN-α/β, as well as protein expressions of some ISGs, such as IFN-inducible transmembrane protein 3 (IFITM3), double-stranded RNA-dependent protein kinase (PKR) and 2′-5′-oligoadenylate synthetase 1 (OAS1), in a dose-dependent manner.
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Cell Line:RAW264.7 cells or RAW264.7 cells infected with IAV A/Fort Monmouth/1/1947 (0.2 MOI)
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Concentration:2 μM
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Incubation Time:0, 2, 4 and 6 h
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Result:Increased protein levels of IRF3 and p-IRF3. Promoted the cytoplasmic protein levels of IRF3 and p-IRF3 in RAW264.7 cells following the enhancement of HO-1 protein expression after 6 h. Induced nuclear IRF3 and nuclear p-IRF3 accumulation within 6 h of treatment.
Chemical Information
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CAS No. 14325-03-2
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Appearance Solid
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Molecular Weight 619.58
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Formula C34H32CoN4O4
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Color Brown to black
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SMILES
CC1=C(CCC([O-])=O)C2=CC(C(CCC([O-])=O)=C3C)=[N]4C3=CC5=C(C)C(C=C)=C6C=C(C(C)=C7C=C)[N]8=C7C=C1[N-]2[Co+2]84[N-]56.[H+].[H+]
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Synonyms
Co-PPIX
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (282 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cobalt protoporphyrin IX Related Classifications
HY-134608 Related Classifications
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