1. PROTAC
  2. PROTAC Linkers
  3. Azido-PEG1-CH2CO2H

Azido-PEG1-CH2CO2H is a PROTAC linker, which refers to the alkyl/ether composition. Azido-PEG1-CH2CO2H can be used in the synthesis of PROTAC BRD4 Degrader-1. Azido-PEG1-CH2CO2H is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

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Azido-PEG1-CH2CO2H Chemical Structure

Azido-PEG1-CH2CO2H Chemical Structure

CAS No. : 79598-48-4

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50 mg USD 85 In-stock
100 mg USD 130 In-stock
250 mg USD 230 In-stock
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Description

Azido-PEG1-CH2CO2H is a PROTAC linker, which refers to the alkyl/ether composition. Azido-PEG1-CH2CO2H can be used in the synthesis of PROTAC BRD4 Degrader-1[1]. Azido-PEG1-CH2CO2H is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

IC50 & Target[1]

Alkyl/ether

 

Molecular Weight

145.12

Formula

C4H7N3O3

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

O=C(O)COCCN=[N+]=[N-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (344.54 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.8908 mL 34.4542 mL 68.9085 mL
5 mM 1.3782 mL 6.8908 mL 13.7817 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.58%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 6.8908 mL 34.4542 mL 68.9085 mL 172.2712 mL
5 mM 1.3782 mL 6.8908 mL 13.7817 mL 34.4542 mL
10 mM 0.6891 mL 3.4454 mL 6.8908 mL 17.2271 mL
15 mM 0.4594 mL 2.2969 mL 4.5939 mL 11.4847 mL
20 mM 0.3445 mL 1.7227 mL 3.4454 mL 8.6136 mL
25 mM 0.2756 mL 1.3782 mL 2.7563 mL 6.8908 mL
30 mM 0.2297 mL 1.1485 mL 2.2969 mL 5.7424 mL
40 mM 0.1723 mL 0.8614 mL 1.7227 mL 4.3068 mL
50 mM 0.1378 mL 0.6891 mL 1.3782 mL 3.4454 mL
60 mM 0.1148 mL 0.5742 mL 1.1485 mL 2.8712 mL
80 mM 0.0861 mL 0.4307 mL 0.8614 mL 2.1534 mL
100 mM 0.0689 mL 0.3445 mL 0.6891 mL 1.7227 mL
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Azido-PEG1-CH2CO2H Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Azido-PEG1-CH2CO2H
Cat. No.:
HY-108369
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