Art. -Nr.: HY-124805

MAL3-101

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MAL3-101 is a potent HSP70 allosteric inhibitor. MAL3-101 inhibits HSP70 ATPase activity by blocking Hsp40 co-chaperone interaction. MAL3-101 can be used for researching muscle invasive bladder cancer (MIBC).

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Reinheit: 98.22%
CAS. Nr.: 831217-40-4
Formel: C₅₄H₆₆N₄O₁₀
Molecular Weight:931.12

Speicherung:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

MAL3-101 Chemical Structure

CAS. Nr.: 831217-40-4

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

HSP70

Alle HSP Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
HT-29	GI₅₀	>50 μM Compound: MAL3-101	Antiproliferative activity against human HT29 cells after 96 hrs by MTS assay Antiproliferative activity against human HT29 cells after 96 hrs by MTS assay	[PMID: 18164205]
MCF7	GI₅₀	14.7 μM Compound: MAL3-101	Antiproliferative activity against human MCF7 cells after 96 hrs by MTS assay Antiproliferative activity against human MCF7 cells after 96 hrs by MTS assay	[PMID: 18164205]
MCF7	GI₅₀	6 μM Compound: MAL3-101	Cytotoxicity against human MCF7 cells assessed as cell growth inhibition after 48 hrs by cell titer-glo assay Cytotoxicity against human MCF7 cells assessed as cell growth inhibition after 48 hrs by cell titer-glo assay	[PMID: 27624078]
SK-BR-3	ED₅₀	8 μM Compound: MAL3-101	Antiproliferative activity against human SK-BR3 cells after 96 hrs by MTS assay Antiproliferative activity against human SK-BR3 cells after 96 hrs by MTS assay	[PMID: 18164205]
SK-BR-3	GI₅₀	27 μM Compound: MAL3-101	Antiproliferative activity against human SK-BR3 cells after 96 hrs by MTS assay Antiproliferative activity against human SK-BR3 cells after 96 hrs by MTS assay	[PMID: 18164205]

In Vitro

MAL3-101 (10 μM; 24, 48, 72 hours) induces cell viability in MIBC cell lines UMUC3, T24, SW780 and J82^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 831217-40-4
Appearance Solid
Molecular Weight 931.12
Formel C₅₄H₆₆N₄O₁₀
Color Off-white to light brown
SMILES

CC(N(C(NC1C2=CC=C(C3=CC=CC=C3)C=C2)=O)CCCCCC(N(CCCCCC)C(C(NCCCC)=O)C4=CC=C(C(C(OC)=O)=C4)OCC(OC)=O)=O)=C1C(OCC5=CC=CC=C5)=O
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 50 mg/mL (53.70 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.0740 mL

5.3699 mL

10.7398 mL

5 mM

0.2148 mL

1.0740 mL

2.1480 mL

10 mM

0.1074 mL

0.5370 mL

1.0740 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 1.25 mg/mL (1.34 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Prince T, et al. Dual targeting of HSP70 does not induce the heat shock response and synergistically reduces cell viability in muscle invasive bladder cancer. Oncotarget. 2018 Aug 24;9(66):32702-32717. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.0740 mL	5.3699 mL	10.7398 mL	26.8494 mL
	5 mM	0.2148 mL	1.0740 mL	2.1480 mL	5.3699 mL
	10 mM	0.1074 mL	0.5370 mL	1.0740 mL	2.6849 mL
	15 mM	0.0716 mL	0.3580 mL	0.7160 mL	1.7900 mL
	20 mM	0.0537 mL	0.2685 mL	0.5370 mL	1.3425 mL
	25 mM	0.0430 mL	0.2148 mL	0.4296 mL	1.0740 mL
	30 mM	0.0358 mL	0.1790 mL	0.3580 mL	0.8950 mL
	40 mM	0.0268 mL	0.1342 mL	0.2685 mL	0.6712 mL
	50 mM	0.0215 mL	0.1074 mL	0.2148 mL	0.5370 mL

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MAL3-101

MCE Bioactive Compound Library

Alle HSP Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

MAL3-101 Related Classifications

Art. -Nr.: HY-124805