MAL3-101
Based on 1 Customer Validation
MAL3-101 is a potent HSP70 allosteric inhibitor. MAL3-101 inhibits HSP70 ATPase activity by blocking Hsp40 co-chaperone interaction. MAL3-101 can be used for researching muscle invasive bladder cancer (MIBC).
For research use only. We do not sell to patients.
- Purity: 98.22%
- CAS No.: 831217-40-4
- Formula: C54H66N4O10
- Molecular Weight:931.12
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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HSP70 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HT-29 | GI50 |
>50 μM
Compound: MAL3-101
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Antiproliferative activity against human HT29 cells after 96 hrs by MTS assay
Antiproliferative activity against human HT29 cells after 96 hrs by MTS assay
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[PMID: 18164205] |
| MCF7 | GI50 |
14.7 μM
Compound: MAL3-101
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Antiproliferative activity against human MCF7 cells after 96 hrs by MTS assay
Antiproliferative activity against human MCF7 cells after 96 hrs by MTS assay
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[PMID: 18164205] |
| MCF7 | GI50 |
6 μM
Compound: MAL3-101
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Cytotoxicity against human MCF7 cells assessed as cell growth inhibition after 48 hrs by cell titer-glo assay
Cytotoxicity against human MCF7 cells assessed as cell growth inhibition after 48 hrs by cell titer-glo assay
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[PMID: 27624078] |
| SK-BR-3 | ED50 |
8 μM
Compound: MAL3-101
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Antiproliferative activity against human SK-BR3 cells after 96 hrs by MTS assay
Antiproliferative activity against human SK-BR3 cells after 96 hrs by MTS assay
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[PMID: 18164205] |
| SK-BR-3 | GI50 |
27 μM
Compound: MAL3-101
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Antiproliferative activity against human SK-BR3 cells after 96 hrs by MTS assay
Antiproliferative activity against human SK-BR3 cells after 96 hrs by MTS assay
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[PMID: 18164205] |
MAL3-101 (10 μM; 24, 48, 72 hours) induces cell viability in MIBC cell lines UMUC3, T24, SW780 and J82[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 831217-40-4
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Appearance Solid
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Molecular Weight 931.12
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Formula C54H66N4O10
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Color Off-white to light brown
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SMILES
CC(N(C(NC1C2=CC=C(C3=CC=CC=C3)C=C2)=O)CCCCCC(N(CCCCCC)C(C(NCCCC)=O)C4=CC=C(C(C(OC)=O)=C4)OCC(OC)=O)=O)=C1C(OCC5=CC=CC=C5)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (53.70 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.0740 mL | 5.3699 mL | 10.7398 mL | 26.8494 mL |
| 5 mM | 0.2148 mL | 1.0740 mL | 2.1480 mL | 5.3699 mL | |
| 10 mM | 0.1074 mL | 0.5370 mL | 1.0740 mL | 2.6849 mL | |
| 15 mM | 0.0716 mL | 0.3580 mL | 0.7160 mL | 1.7900 mL | |
| 20 mM | 0.0537 mL | 0.2685 mL | 0.5370 mL | 1.3425 mL | |
| 25 mM | 0.0430 mL | 0.2148 mL | 0.4296 mL | 1.0740 mL | |
| 30 mM | 0.0358 mL | 0.1790 mL | 0.3580 mL | 0.8950 mL | |
| 40 mM | 0.0268 mL | 0.1342 mL | 0.2685 mL | 0.6712 mL | |
| 50 mM | 0.0215 mL | 0.1074 mL | 0.2148 mL | 0.5370 mL |
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