1. GPCR/G Protein Neuronal Signaling
  2. Orexin Receptor (OX Receptor)
  3. Cudarolimab

Cudarolimab  (Synonyms: IBI101)

Cat. No.: HY-P99836 Purity: 95.00%
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Cudarolimab (IBI101) is a completely human anti-OX40 (CD134, a co stimulating molecule expressed by activated immune cells) antibody. Cudarolimab inhibits the binding of OX40 to its ligand OX40L. Cudarolimab has antitumor activity and can be used in cancer related research.

For research use only. We do not sell to patients.

Cudarolimab Chemical Structure

Cudarolimab Chemical Structure

CAS No. : 2244739-29-3

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Description

Cudarolimab (IBI101) is a completely human anti-OX40 (CD134, a co stimulating molecule expressed by activated immune cells) antibody. Cudarolimab inhibits the binding of OX40 to its ligand OX40L. Cudarolimab has antitumor activity and can be used in cancer related research[1].

In Vitro

Cudarolimab (0.01, 1, 100 or 10000 nM) binds to OX40 and partially blocks the binding of OX40 to its ligand OX40L in CHO-S cells overexpressing human OX40 (CHO-S-hOX40). Cudarolimab activates OX40 dependent NF-κB reporters with an EC50 value of 4.432 nM in Jurkat-OX40 reporter cells co-cultured with Raji cells[1].
Cudarolimab (0.01, 0.1, 1, 10, 100 or 1000 nM) binds to activated human CD4+ T cells and activated cynomolgus monkey CD4+ T cells in a dose dependent manner[1].
Cudarolimab (0.4, 4.0 and 40.4 nM) increases IL-2 secretion with dose dependent manner in human CD4+ T cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Cudarolimab (10 mg/kg; i.p.; single dose on days 3, 7, 11, 14 and 15) significantly reduces tumor volume in humanized NOG mice bearing LoVo tumors[1].
Cudarolimab (0.1, 1 and 10 mg/kg; i.p.; single dose on days 6, 9, 12 and 16) significantly reduces tumor volume, increases IFN-γ+ and IFN-α+ expression in CD8+ T cells in tumor and spleen of human OX40 knock-in mice bearing MC38 tumors[1].
Cudarolimab (10 mg/kg; i.p.; single dose on days 10 and 14) significantly reduces the expression of CD3+CD8+, CD3+CD4+, CD4+CD25highFoxP3+ in the tumor and spleen of human OX40 knock-in mice bearing MC38 tumors[1].
Pharmacokinetic (PK) parameters of Cudarolimab in cynomolgus macaques[1]

Dose (mg/kg) Cmax (µg/mL ) Tmax (h) AUC0-∞ (h•µg/mL ) T1/2 (h) Cl (mL/h/kg) MRTlast (h)
0.1 3.07±0.40 0.08±0.00 347.98±99.30 162.98±103.01 0.31±0.08 186.34±110.68
0.5 9.78±3.27 0.40±0.78 1429.19±607.21 129.47±114.44 0.40±0.14 136.03±108.05
2.5 63.10±15.29 0.08±0.00 10304.06±3403.59 190.89±92.94 0.27±0.09 212.29±114.61
12.5 296.57±58.05 0.40±0.78 33511.65±14982.36 120.30±153.26 0.44±0.20 114.93±87.66

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Humanized NOG mice bearing LoVo tumors[1].
Dosage: 10 mg/kg.
Administration: Intraperitoneal injection; single dose on days 3, 7, 11, 14 and 15.
Result: Reduced tumor volume.
Animal Model: Human OX40 knock-in mice bearing MC38 tumors[1].
Dosage: 0.1, 1 and 10 mg/kg.
Administration: Intraperitoneal injection; single dose on days 6, 9, 10, 12, 14 and 16.
Result: Showed anti-tumor activity.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Cudarolimab]

Shipping

Shipping with dry ice.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Purity: 95.00%

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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