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USH1C Protein, Human (His-SUMO)

Cat. No.: HY-P71659
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USH1C is an anchoring and scaffolding protein critical for cochlear hair cell mechanotransduction. It forms a network with USH1G, CDH23 and MYO7A and contributes to the development and maintenance of hair cell bundles. USH1C Protein, Human (His-SUMO) is the recombinant human-derived USH1C protein, expressed by E. coli , with N-His, N-SUMO labeled tag. The total length of USH1C Protein, Human (His-SUMO) is 533 a.a., with molecular weight of ~76.3 kDa.

For research use only. We do not sell to patients.

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Description

USH1C is an anchoring and scaffolding protein critical for cochlear hair cell mechanotransduction. It forms a network with USH1G, CDH23 and MYO7A and contributes to the development and maintenance of hair cell bundles. USH1C Protein, Human (His-SUMO) is the recombinant human-derived USH1C protein, expressed by E. coli , with N-His, N-SUMO labeled tag. The total length of USH1C Protein, Human (His-SUMO) is 533 a.a., with molecular weight of ~76.3 kDa.

Background

USH1C, an anchoring and scaffolding protein, plays a crucial role in the mechanotransduction process within cochlear hair cells, forming an intricate network with USH1G, CDH23, and MYO7A. It is essential for the normal development and maintenance of cochlear hair cell bundles. As a component of the intermicrovillar adhesion complex (IMAC), USH1C contributes to brush border differentiation, exerting control over microvilli organization and length. Its regulatory significance is evident in the assembly of the complex, where it recruits CDHR2, CDHR5, and MYO7B to the tips of microvilli. USH1C participates in various complexes, including IMAC and the complex composed of USH1C, USH1G, and MYO7A. Its interactions extend to F-actin, USH2A, SLC4A7, USHBP1, CDH23, USH1G, MYO7B, CDHR2, CDHR5, and ANKS4B, emphasizing its multifaceted role in cellular processes and protein associations.

Species

Human

Source

E. coli

Tag

N-His;N-SUMO

Accession

Q9Y6N9-4(M1-F533)

Gene ID
Molecular Construction
N-term
6*His-SUMO
USH1C (M1-F533)
Accession # Q9Y6N9-4
C-term
Synonyms
AIE 75; AIE75; Antigen NY CO 38/NY CO 37; Deafness autosomal recessive 18; DFNB 18; DFNB18
AA Sequence

MDRKVAREFRHKVDFLIENDAEKDYLYDVLRMYHQTMDVAVLVGDLKLVINEPSRLPLFDAIRPLIPLKHQVEYDQLTPRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKGGQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPLTWQYVDQFVSESGGVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKPGIFISHVKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEGRELFMTDRERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRKEMEQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPKYDQGVEPELEPADDLDGGTEEQGEQDFRKYEEGFDPYSMFTPEQIMGKDVRLLRIKKEGSLDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVKGDEIMAINGKIVTDYTLAEAEAALQKAWNQGGDWIDLVVAVCPPKEYDDELTFF

Molecular Weight

Approximately 76.3 kDa

Purity

Greater than 90% as determined by reducing SDS-PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

USH1C Protein, Human (His-SUMO) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Product Name:
USH1C Protein, Human (His-SUMO)
Cat. No.:
HY-P71659
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