USH1C Protein, Human (His-SUMO)
USH1C is an anchoring and scaffolding protein critical for cochlear hair cell mechanotransduction. It forms a network with USH1G, CDH23 and MYO7A and contributes to the development and maintenance of hair cell bundles. USH1C Protein, Human (His-SUMO) is the recombinant human-derived USH1C protein, expressed by E. coli , with N-His, N-SUMO labeled tag.
- Species: Human
- Source: E. coli
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
USH1C is an anchoring and scaffolding protein critical for cochlear hair cell mechanotransduction. It forms a network with USH1G, CDH23 and MYO7A and contributes to the development and maintenance of hair cell bundles. USH1C Protein, Human (His-SUMO) is the recombinant human-derived USH1C protein, expressed by E. coli , with N-His, N-SUMO labeled tag.
Background
USH1C, an anchoring and scaffolding protein, plays a crucial role in the mechanotransduction process within cochlear hair cells, forming an intricate network with USH1G, CDH23, and MYO7A. It is essential for the normal development and maintenance of cochlear hair cell bundles. As a component of the intermicrovillar adhesion complex (IMAC), USH1C contributes to brush border differentiation, exerting control over microvilli organization and length. Its regulatory significance is evident in the assembly of the complex, where it recruits CDHR2, CDHR5, and MYO7B to the tips of microvilli. USH1C participates in various complexes, including IMAC and the complex composed of USH1C, USH1G, and MYO7A. Its interactions extend to F-actin, USH2A, SLC4A7, USHBP1, CDH23, USH1G, MYO7B, CDHR2, CDHR5, and ANKS4B, emphasizing its multifaceted role in cellular processes and protein associations.
Technical Parameters
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Species Human
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Source E. coli
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Tag N-His;N-SUMO
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Accession
Q9Y6N9-4 (M1-F533)
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Molecular Construction
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N-term
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6*His-SUMO
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USH1C (M1-F533)
Accession # Q9Y6N9-4 -
C-term
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Protein Length
Full Length of Isoform-4
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Synonyms
USH1C; USH1 Protein Network Component; Harmonin; DFNB18; NY-CO-37; NY-CO-38; PDZ-73; AIE-75; PDZD7C; PDZ73; Usher Syndrome 1C (Autosomal Recessive, Severe); Autoimmune Enteropathy-Related Antigen AIE-75; Renal Carcinoma Antigen NY-REN-3; Usher Syndrome Type-1C Protein; Antigen NY-CO-38/NY-CO-37; Usher Syndrome 1C (Autosomal Recessive, Severe), Isoform CRA_a; Deafness, Autosomal Recessive 18; Usher Syndrome 1C Isoform 1; Usher Syndrome 1C; PDZ-73/NY-CO-38; Protein PDZ-73; Ush1cpst; DFNB18A; PDZ-45; AIE75
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AA Sequence
MDRKVAREFRHKVDFLIENDAEKDYLYDVLRMYHQTMDVAVLVGDLKLVINEPSRLPLFDAIRPLIPLKHQVEYDQLTPRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKGGQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPLTWQYVDQFVSESGGVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKPGIFISHVKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEGRELFMTDRERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRKEMEQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPKYDQGVEPELEPADDLDGGTEEQGEQDFRKYEEGFDPYSMFTPEQIMGKDVRLLRIKKEGSLDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVKGDEIMAINGKIVTDYTLAEAEAALQKAWNQGGDWIDLVVAVCPPKEYDDELTFF
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Predicted Molecular Mass
76.3 kDa
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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