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APJ receptor agonist 1 

Cat. No.: HY-133036
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APJ receptor agonist 1, a biphenyl acid derivative, is a potent APJ receptor (APJ-R) agonist (EC50s 0.093 and 0.12 nM for human and rat APJ-R, respectively). APJ receptor agonist 1 displays in vitro potency to apelin-13, the endogenous peptidic ligand for the APJ receptor. APJ receptor agonist 1 has the potential for the research of heart failure.

For research use only. We do not sell to patients.

APJ receptor agonist 1 Chemical Structure

APJ receptor agonist 1 Chemical Structure

CAS No. : 2287153-38-0

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Description

APJ receptor agonist 1, a biphenyl acid derivative, is a potent APJ receptor (APJ-R) agonist (EC50s 0.093 and 0.12 nM for human and rat APJ-R, respectively). APJ receptor agonist 1 displays in vitro potency to apelin-13, the endogenous peptidic ligand for the APJ receptor. APJ receptor agonist 1 has the potential for the research of heart failure[1].

In Vitro

The S-atropisomer APJ receptor agonist 1 (compound 15a) is 200-fold more potent than the corresponding R-atropisomer.[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

APJ receptor agonist 1 (10-100 μg/min/kg; intravenous infusion) induces a 10% increase in CO with minimal impact on blood pressure (<5% transient blood pressure drop)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Isoflurane-anesthetized male Sprague Dawley rats[1]
Dosage: 10, 100, 1000 μg/kg/min
Administration: IV; infused into the jugular vein for 15 min
Result: Showed a dose-dependent improvement in the cardiac output in male Sprague Dawley rats with no significant changes in either mean arterial blood pressure or heart rate.
Molecular Weight

524.01

Formula

C₃₁H₂₆ClN₃O₃

CAS No.
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APJ receptor agonist 1
Cat. No.:
HY-133036
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