2. GPCR/G Protein
  3. Apelin Receptor (APJ)
  4. APJ receptor agonist 1

APJ receptor agonist 1, a biphenyl acid derivative, is a potent APJ receptor (APJ-R) agonist (EC50s 0.093 and 0.12 nM for human and rat APJ-R, respectively). APJ receptor agonist 1 displays in vitro potency to apelin-13, the endogenous peptidic ligand for the APJ receptor. APJ receptor agonist 1 has the potential for the research of heart failure.

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APJ receptor agonist 1 Chemical Structure

APJ receptor agonist 1 Chemical Structure

CAS No. : 2287153-38-0

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APJ receptor agonist 1 Related Antibodies

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Description

APJ receptor agonist 1, a biphenyl acid derivative, is a potent APJ receptor (APJ-R) agonist (EC50s 0.093 and 0.12 nM for human and rat APJ-R, respectively). APJ receptor agonist 1 displays in vitro potency to apelin-13, the endogenous peptidic ligand for the APJ receptor. APJ receptor agonist 1 has the potential for the research of heart failure[1].

In Vitro

The S-atropisomer APJ receptor agonist 1 (compound 15a) is 200-fold more potent than the corresponding R-atropisomer.[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

APJ receptor agonist 1 Related Antibodies
In Vivo

APJ receptor agonist 1 (10-100 μg/min/kg; intravenous infusion) induces a 10% increase in CO with minimal impact on blood pressure (<5% transient blood pressure drop)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Isoflurane-anesthetized male Sprague Dawley rats[1]
Dosage: 10, 100, 1000 μg/kg/min
Administration: IV; infused into the jugular vein for 15 min
Result: Showed a dose-dependent improvement in the cardiac output in male Sprague Dawley rats with no significant changes in either mean arterial blood pressure or heart rate.
Molecular Weight

524.01

Formula

C31H26ClN3O3
CAS No.
SMILES

O=C(C1=CC(C(N[C@@H](C2=CC=CC=C2)CCC)=O)=CC=[C@]1[C@]3=C(Cl)C=CC=C3C4=NC5=CC=CC=C5N4)O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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APJ receptor agonist 1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

APJ receptor agonist 12287153-38-0APJ receptor agonist1APJ receptor agonist-1Apelin Receptor (APJ)heartfailureapelinligandCOcardiacoutputInhibitorinhibitorinhibit

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