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  4. Tributyl citrate

Tributyl citrate is a low-toxicity and orally active citrate ester with no genotoxicity or skin sensitizing activity. Tributyl citrate also acts as a plasticizer, solvent, FDA-approved indirect food additive, and topical anesthetic, among other uses. Tributyl citrate induces a needle-prick insensitivity response that lasts for more than 2 hours, and a 5% suspension of it temporarily eliminates the corneal reflex in rabbits. Tributyl citrate causes no significant systemic toxicity in rats and cats at most tested doses, and only may cause growth retardation and gastrointestinal reactions such as diarrhea and nausea at high doses or with repeated oral administration.

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Tributyl citrate

Tributyl citrate Chemical Structure

CAS No. : 77-94-1

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Liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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10 mM * 1 mL in DMSO In-stock
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100 g In-stock
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Based on 1 publication(s) in Google Scholar

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Tributyl citrate Related Antibodies

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Description

Tributyl citrate is a low-toxicity and orally active citrate ester with no genotoxicity or skin sensitizing activity. Tributyl citrate also acts as a plasticizer, solvent, FDA-approved indirect food additive, and topical anesthetic, among other uses. Tributyl citrate induces a needle-prick insensitivity response that lasts for more than 2 hours, and a 5% suspension of it temporarily eliminates the corneal reflex in rabbits. Tributyl citrate causes no significant systemic toxicity in rats and cats at most tested doses, and only may cause growth retardation and gastrointestinal reactions such as diarrhea and nausea at high doses or with repeated oral administration[1][2].

In Vitro

Tributyl citrate does not induce chromosome aberrations in human peripheral blood lymphocytes in vitro[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tributyl citrate Related Antibodies
In Vivo

Tributyl citrate (dietary supplement, 5-10%, daily for 6 weeks) has no effect on body weight gain in rats, while the 10% concentration reduces body weight gain in rats, which may be related to diarrhea; no other toxic effects are observed[1].
Tributyl citrate (5 mL/kg; p.o.; daily; for consecutive 2 months) exerts no significant effects on cats[1].
Tributyl citrate (580 mg/kg; i.p.; daily; 14 days) reduces body weight gain in mice without causing hematological or histopathological changes[1].
Tributyl citrate (30 mL/kg; p.o.; single administration) does not cause death in brown rats and cats[1].
The intraperitoneal median lethal dose of Tributyl citrate in Swiss albino mice is 2900 mg/kg[1].
Tributyl citrate (5% gum arabic suspension; 3 drops; ocular administration; single dose) temporarily eliminates the corneal reflex in Oryctolagus cuniculus[1].
Tributyl citrate (2% solution, 0.1 mL; intradermal injection; single dose) induces more than 2 hours of sensory loss to acupuncture stimulation in guinea pigs[1].
Tributyl citrate (5-10%; p.o.; daily; for 6 weeks) causes growth inhibition (possibly induced by diarrhea) in immature Wistar rats only at the 10% dose, with no systemic toxicity, changes in blood cell counts or organ abnormalities[2].
Tributyl citrate (10-30 cc/kg; p.o.; single administration) causes transient hypokinesia and rectal leakage but no systemic toxicity in Wistar rats at a single oral dose up to 30 cc/kg[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rat[1]
Dosage: 5% (diet); 10% (diet)
Administration: diet; daily; 6 weeks
Result: Showed no effect on body weight gain in the 5% group.
Decreased body weight gains in the 10% group, possibly attributable to frequent diarrhea.
Reported no effects on blood counts.
Observed no microscopic lesions.
Animal Model: Wistar Rat (immature, 21 days old, 10 males and 12 females)[2]
Dosage: 5% concentration in diet; 10% concentration in diet
Administration: p.o.; daily; 6 weeks
Result: Showed no deleterious effect on growth curves at 5% concentration in diet.
Tended to depress growth at 10% concentration in diet, likely due to frequent diarrhea.
Displayed wide fluctuations in complete blood counts but no conspicuous differences from control values.
Showed no gross abnormalities in thoracic or abdominal organs.
Had histological sections of the heart, lungs, gastrointestinal tract, liver, pancreas, spleen, and kidneys indistinguishable from controls.
Molecular Weight

360.45

Formula

C18H32O7
CAS No.
Appearance

Liquid (Density: 1.080±0.06 g/cm3)

Color

Colorless to light yellow

SMILES

O=C(CC(C(OCCCC)=O)(O)CC(OCCCC)=O)OCCCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (277.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7743 mL 13.8715 mL 27.7431 mL
5 mM 0.5549 mL 2.7743 mL 5.5486 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  20% SBE-β-CD in Saline

    Solubility: 40 mg/mL (110.97 mM); Suspended solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.33%

SDS (396 KB)

COA (244 KB) HNMR (244 KB) RP-HPLC (246 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7743 mL 13.8715 mL 27.7431 mL 69.3577 mL
5 mM 0.5549 mL 2.7743 mL 5.5486 mL 13.8715 mL
10 mM 0.2774 mL 1.3872 mL 2.7743 mL 6.9358 mL
15 mM 0.1850 mL 0.9248 mL 1.8495 mL 4.6238 mL
20 mM 0.1387 mL 0.6936 mL 1.3872 mL 3.4679 mL
25 mM 0.1110 mL 0.5549 mL 1.1097 mL 2.7743 mL
30 mM 0.0925 mL 0.4624 mL 0.9248 mL 2.3119 mL
40 mM 0.0694 mL 0.3468 mL 0.6936 mL 1.7339 mL
50 mM 0.0555 mL 0.2774 mL 0.5549 mL 1.3872 mL
60 mM 0.0462 mL 0.2312 mL 0.4624 mL 1.1560 mL
80 mM 0.0347 mL 0.1734 mL 0.3468 mL 0.8670 mL
100 mM 0.0277 mL 0.1387 mL 0.2774 mL 0.6936 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tributyl77-94-1Biochemical Assay ReagentsEnvironmental PollutantsEnvironmental Contaminantsratshuman peripheral blood lymphocytesSwiss albino miceimmature Wistar ratscatsrabbit eyesguinea pigsskin sensitizer activitychromosome aberrationscorneal reflexInhibitorinhibitorinhibit

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