Croscarmellose sodium
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Croscarmellose sodium is a commonly used pharmaceutical additive approved by the US Food and Drug Administration (FDA). Croscarmellose sodium is used as excipients, such as the suspending agent, binder, glidant, antiadherent, and disintegrants.
For research use only. We do not sell to patients.
- CAS No.: 74811-65-7
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Biological Activity
Croscarmellose sodium is a commonly used pharmaceutical excipient. Pharmaceutical excipient refers to the inactive chemical substances used in the pharmaceutical process other than pharmaceutical ingredients, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[2].
Croscarmellose sodium promotes the dissolution of poorly soluble compounds in water, and can be used as suspending agent in injections. Croscarmellose sodium improves the fluidity of drugs as a lubricant in tables. Croscarmellose sodium prevents drug particles from adhering to the mold as an anti-adherent agent. Croscarmellose sodium acts as a disintegrant that rapidly absorbs water and swells, causing the drug to disintegrate rapidly in the gastrointestinal tract, thereby accelerating drug release and absorption. Croscarmellose sodium acts also as an additive in the food industry for thickening or stabilization[1][3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 74811-65-7
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Appearance Solid
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Color White to off-white
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SMILES
[Croscarmellose sodium]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Purity & Documentation
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Data Sheet (267 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Mumoli N, et al. Allergic reaction to Croscarmellose sodium used as excipient of a generic drug. QJM. 2011 Aug;104(8):709-10. [Content Brief]
[2]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99. [Content Brief]
[3]. Gordon MS, et al., Effect of the mode of croscarmellose sodium incorporation on tablet dissolution and friability. J Pharm Sci. 1990 Jan;79(1):43-7. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)