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Celite (Diatomaceous earth) is a filter aid. Celite induces hepatic tryptophan oxygenase activity and reduces hepatic glycogen in mouse experiments. Celite can be used for studies of endotoxemia.

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Celite

Celite Chemical Structure

CAS No. : 61790-53-2

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Based on 1 publication(s) in Google Scholar

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Description

Celite (Diatomaceous earth) is a filter aid. Celite induces hepatic tryptophan oxygenase activity and reduces hepatic glycogen in mouse experiments. Celite can be used for studies of endotoxemia[1].

In Vivo

Celite (5 mg; i.p.; daily; 5 days) induces sustained activation of hepatic tryptophan oxygenase in mice, reduces the level of endogenous hepatic glycogen, and exerts no effect on the carbon clearance function of the reticuloendothelial system[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss albino (male, 25 ± 2 g)[1]
Dosage: 5 mg
Administration: i.p.; daily; 5 days
Result: Achieved 45% survival rate following LD50 endotoxin challenge without concurrent cortisone treatment, and 100% survival rate with concurrent cortisone treatment.
Induced fully elevated liver TO activity, significantly above saline control levels.
Reduced the level of endogenous hepatic glycogen.
Showed a carbon clearance K value of 0.048, not significantly different from saline control levels.
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[Celite]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Store at room temperature, keep dry and cool

In solvent -80°C 1 year
-20°C 6 months
Purity & Documentation

SDS (418 KB)

COA (250 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Celite61790-53-2Diatomaceous earthBiochemical Assay ReagentsEnvironmental PollutantsEnvironmental Contaminantsliver tryptophan oxygenase micecarbon clearanceratesInhibitorinhibitorinhibit

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