CDC37 Protein, Mouse (sf9, His-GST)
The CDC37 protein is a co-chaperone that binds to kinases and promotes their interaction with Hsp90 complexes, thereby stabilizing and activating them. It inhibits the ATPase activity of HSP90AA1. CDC37 Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived CDC37 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.
- Species: Mouse
- Source: Sf9 insect cells
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
The CDC37 protein is a co-chaperone that binds to kinases and promotes their interaction with Hsp90 complexes, thereby stabilizing and activating them. It inhibits the ATPase activity of HSP90AA1. CDC37 Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived CDC37 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.
Background
CDC37 protein is a co-chaperone that binds to various kinases and facilitates their interaction with the Hsp90 complex, leading to the stabilization and activation of these kinases. It inhibits the ATPase activity of HSP90AA1. It is likely to form a complex consisting of chaperones HSP90 and HSP70, co-chaperones STIP1/HOP, CDC37, PPP5C, PTGES3/p23, TSC1, and client protein TSC2. This complex may also include CDK4, AKT, RAF1, and NR3C1, but does not contain STIP1/HOP and PTGES3/p23. CDC37 forms a separate complex with Hsp90/HSP90AB1 and CDK6. It interacts with several proteins including HSP90AA1, AR, CDK4, CDK6, EIF2AK1, RB1, KSR1, FLCN, FNIP1, and FNIP2.
Technical Parameters
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Species Mouse
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Source Sf9 insect cells
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Tag N-His;N-GST
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Accession
Q61081 (M1-A379)
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Molecular Construction
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N-term
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His-GST
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CDC37 (M1-A379)
Accession # Q61081 -
C-term
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Protein Length
Full Length
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Synonyms
CDC37; CDC37 Cell Division Cycle 37 Homolog; Cell Division Cycle 37, HSP90 Cochaperone; P50Cdc37; Hsp90 Co-Chaperone Cdc37; CDC37 Cell Division Cycle 37 Homolog (S. Cerevisiae); Hsp90 Chaperone Protein Kinase-Targeting Subunit; Cell Division Cycle 37 Homo
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AA Sequence
MVDYSVWDHIEVSDDEDETHPNIDTASLFRWRHQARVERMEQFQKEKEELDRGCRECKRKVAECQRKLKELEVAESDGQVELERLRAEAQQLRKEERSWEQKLEDMRKKEKNMPWNVDTLSKDGFSKSMVNTKPEKAEEDSEEAREQKHKTFVEKYEKQIKHFGMLHRWDDSQKYLSDNVHLVCEETANYLVIWCIDLEVEEKCALMEQVAHQTMVMQFILELAKSLKVDPRACFRQFFTKIKTADHQYMEGFKYELEAFKERVRGRAKLRIEKAMKEYEEEERKKRLGPGGLDPVEVYESLPEELQKCFDVKDVQMLQDAISKMDPTDAKYHMQRCIDSGLWVPNSKSGEAKEGEEAGPGDPLLEAVPKAGNEKDVSA
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Predicted Molecular Mass
72.4 kDa
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Molecular Weight
Approximately 66 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 85%, as determined by reducing SDS-PAGE.
Product Properties
Solution
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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