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CDC37 Protein, Mouse (sf9, His-GST)

Cat. No.: HY-P75362
Handling Instructions

The CDC37 protein is a co-chaperone that binds to kinases and promotes their interaction with Hsp90 complexes, thereby stabilizing and activating them. It inhibits the ATPase activity of HSP90AA1. CDC37 Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived CDC37 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of CDC37 Protein, Mouse (sf9, His-GST) is 379 a.a., with molecular weight of ~66 kDa.

For research use only. We do not sell to patients.

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Description

The CDC37 protein is a co-chaperone that binds to kinases and promotes their interaction with Hsp90 complexes, thereby stabilizing and activating them. It inhibits the ATPase activity of HSP90AA1. CDC37 Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived CDC37 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of CDC37 Protein, Mouse (sf9, His-GST) is 379 a.a., with molecular weight of ~66 kDa.

Background

CDC37 protein is a co-chaperone that binds to various kinases and facilitates their interaction with the Hsp90 complex, leading to the stabilization and activation of these kinases. It inhibits the ATPase activity of HSP90AA1. It is likely to form a complex consisting of chaperones HSP90 and HSP70, co-chaperones STIP1/HOP, CDC37, PPP5C, PTGES3/p23, TSC1, and client protein TSC2. This complex may also include CDK4, AKT, RAF1, and NR3C1, but does not contain STIP1/HOP and PTGES3/p23. CDC37 forms a separate complex with Hsp90/HSP90AB1 and CDK6. It interacts with several proteins including HSP90AA1, AR, CDK4, CDK6, EIF2AK1, RB1, KSR1, FLCN, FNIP1, and FNIP2.

Species

Mouse

Source

Sf9 insect cells

Tag

N-His;N-GST

Accession

Q61081 (M1-A379)

Gene ID

12539  [NCBI]

Molecular Construction
N-term
His-GST
CDC37 (M1-A379)
Accession # Q61081
C-term
Synonyms
Hsp90 co-chaperone Cdc37; CDC37; CDC37A
Molecular Weight

Approximately 66 kDa

Purity

Greater than 85% as determined by reducing SDS-PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

CDC37 Protein, Mouse (sf9, His-GST) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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CDC37 Protein, Mouse (sf9, His-GST)
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HY-P75362
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