Cdc37 - cell division cycle 37 Gene

Also Known as p50; p50Cdc37

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12539

Summary

Enables HSP90 protein binding activity and kinase binding activity. Contributes to protein kinase regulator activity. Involved in positive regulation of Mitophagy in response to mitochondrial depolarization; posttranscriptional regulation of gene expression; and regulation of protein kinase activity. Located in cytosol. Part of HSP90-CDC37 chaperone complex. Is expressed in 2-cell stage embryo and 4-cell stage embryo. Orthologous to human CDC37 (cell division cycle 37, HSP90 cochaperone). [provided by Alliance of Genome Resources, Apr 2022]

Cdc37 Products (2)

mRNA Protein Name
NM_001378796.1 NP_001365725.1 hsp90 co-chaperone Cdc37 isoform 1
NM_016742.5 NP_058022.1 hsp90 co-chaperone Cdc37 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables Hsp90 protein binding IDA
IDA: Inferred from direct assay
17189825 MGI
enables kinase binding IPI
IPI: Inferred from physical interaction
21855797 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
23428871 MGI
contributes to protein kinase regulator activity IDA
IDA: Inferred from direct assay
21855797 MGI
Biological Process GO Annotation Evidence References Source
involved in positive regulation of type 2 mitophagy IDA
IDA: Inferred from direct assay
21855797 MGI
involved in post-transcriptional regulation of gene expression IDA
IDA: Inferred from direct assay
21855797 MGI
involved in regulation of protein kinase activity IDA
IDA: Inferred from direct assay
21855797 MGI
Cellular Component GO Annotation Evidence References Source
part of HSP90-CDC37 chaperone complex IDA
IDA: Inferred from direct assay
21855797 MGI
located in cytosol IDA
IDA: Inferred from direct assay
17189825 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

hsp90 co-chaperone Cdc37

  • cell division cycle 37 homolog

  • hsp90 chaperone protein kinase-targeting subunit

Recombinant Cdc37 Proteins

Cat. No. Product Name Accession Purity
HY-P75362 CDC37 Protein, Mouse (sf9, His-GST) Q61081 (M1-A379) ≥ 85%, as determined by reducing SDS-PAGE.
HY-P75363 CDC37 Protein, Mouse (sf9) Q61081 (N-G&P, M1-A379) ≥ 85%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (14)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-139301 DDO-5936 Inhibitor 98.33% Unkown
HY-N1986 Cucurbitacin D 99.93% Unkown
HY-144650 Hsp90-Cdc37-IN-3 98.09% Unkown
HY-119906 Conglobatin 95.48% Unkown
HY-169947 DDO-6079 Inhibitor 98.92% Unkown
HY-111414 Hsp90-Cdc37-IN-1 Inhibitor 99.66% Unkown
HY-147125 DDO-6600 99.2% Unkown
HY-N3417 Kongensin A 98.0% Unkown
HY-130624 Hsp90-Cdc37-IN-2 / Unkown
HY-174347 Hsp90-Cdc37-IN-4 / Unkown
HY-RS02297 CDC37 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02298 CDC37L1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17502 Cdc37 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23959 Cdc37 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cdc37 NCBI NCBI:11140