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Cat. No.: HY-130624

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Hsp90-Cdc37-IN-2

Hsp90-Cdc37-IN-2 (Compound 41) is an inhibitor for the interaction between heat shock protein 90 (Hsp90) and cyclin 37 (Cdc37). Hsp90-Cdc37-IN-2 inhibits the proliferation of cancer cell A549, MCF-7, HOS and HepG2 with IC₅₀ of 0.41-0.94 μM. Hsp90-Cdc37-IN-2 decreases the mitochondrial membrane potential, induces apoptosis, and arrest cell cycle at G0/G1 phase in A549.

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CAS No.: 2413849-81-5
Formule: C₄₂H₄₈FNO₆
Masse moléculaire:681.83

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Hsp90-Cdc37-IN-2 Chemical Structure

CAS No.: 2413849-81-5

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Activité biologique
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- Cellular Effect
Chemical Information
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Activité biologique

Description

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Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.41 μM Compound: 41	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 31725288]
HepG2	IC₅₀	0.94 μM Compound: 41	Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 31725288]
HOS	IC₅₀	0.9 μM Compound: 41	Antiproliferative activity against human HOS cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human HOS cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 31725288]
MCF7	IC₅₀	0.64 μM Compound: 41	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 31725288]

Chemical Information

CAS No. 2413849-81-5
Masse moléculaire 681.83
Formule C₄₂H₄₈FNO₆
SMILES

C[C@@]12[C@]([C@@]3([H])[C@@](CC1)(CC[C@](C)(C3)C(OCCCOC(/C=C(C4=CC=C(C=C4)F)\C#N)=O)=O)C)(CC[C@@]5(C2=CC=C6C5=CC(C(O)=C6C)=O)C)C
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Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Li N, et al., Discovery of Novel Celastrol Derivatives as Hsp90-Cdc37 Interaction Disruptors with Antitumor Activity. J Med Chem. 2019 Dec 12;62(23):10798-10815. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
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Chemical Information
Pureté et documentation
Références

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Hsp90-Cdc37-IN-2

Voir tous les produits spécifiques à Isoform HSP

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Hsp90-Cdc37-IN-2 Related Classifications

HY-130624 Related Classifications