Hsp90-Cdc37-IN-2
Hsp90-Cdc37-IN-2 (Compound 41) is an inhibitor for the interaction between heat shock protein 90 (Hsp90) and cyclin 37 (Cdc37). Hsp90-Cdc37-IN-2 inhibits the proliferation of cancer cell A549, MCF-7, HOS and HepG2 with IC50 of 0.41-0.94 μM. Hsp90-Cdc37-IN-2 decreases the mitochondrial membrane potential, induces apoptosis, and arrest cell cycle at G0/G1 phase in A549.
For research use only. We do not sell to patients.
- CAS No.: 2413849-81-5
- Formula: C42H48FNO6
- Molecular Weight:681.83
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
0.41 μM
Compound: 41
|
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
|
[PMID: 31725288] |
| HepG2 | IC50 |
0.94 μM
Compound: 41
|
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
|
[PMID: 31725288] |
| HOS | IC50 |
0.9 μM
Compound: 41
|
Antiproliferative activity against human HOS cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human HOS cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
|
[PMID: 31725288] |
| MCF7 | IC50 |
0.64 μM
Compound: 41
|
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
|
[PMID: 31725288] |
Chemical Information
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CAS No. 2413849-81-5
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Molecular Weight 681.83
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Formula C42H48FNO6
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SMILES
C[C@@]12[C@]([C@@]3([H])[C@@](CC1)(CC[C@](C)(C3)C(OCCCOC(/C=C(C4=CC=C(C=C4)F)\C#N)=O)=O)C)(CC[C@@]5(C2=CC=C6C5=CC(C(O)=C6C)=O)C)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)