C2/Complement C2 Protein, Cynomolgus (HEK293, His)
Complement C2 is a component of the classical pathway of the complement system and is cleaved by activated factor C1, resulting in the formation of two distinct fragments: C2b and C2a. The subsequent serine protease activity of C2a is critical for its subsequent interaction with the complement factor C4b, leading to the formation of C3 or C5 convertase. C2/Complement C2 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived C2/Complement C2 protein, expressed by HEK293 , with C-His labeled tag.
- Species: Cynomolgus
- Source: HEK293
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Biological Activity
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Product Properties
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Biological Activity
Complement C2 is a component of the classical pathway of the complement system and is cleaved by activated factor C1, resulting in the formation of two distinct fragments: C2b and C2a. The subsequent serine protease activity of C2a is critical for its subsequent interaction with the complement factor C4b, leading to the formation of C3 or C5 convertase. C2/Complement C2 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived C2/Complement C2 protein, expressed by HEK293 , with C-His labeled tag.
Complement C2, a vital component of the classical pathway within the complement system, undergoes cleavage by activated factor C1 into two fragments: C2b and C2a. The generated C2a fragment, possessing serine protease activity, subsequently associates with complement factor C4b, culminating in the formation of the C3 or C5 convertase. This enzymatic complex plays a pivotal role in the activation cascade of the complement system, facilitating the downstream proteolytic cleavage of complement factors C3 and C5, which are integral steps in the immune response. The orchestrated interplay of C2 in the classical pathway underscores its significance in mediating immune defense mechanisms and maintaining immune homeostasis. (
Technical Parameters
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Species Cynomolgus
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Source HEK293
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Tag C-8*His
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Accession
A0A2K5U0I4/XP_005553508.1 (A21-L752)
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Molecular Construction
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N-term
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C2 (A21-L752)
Accession # A0A2K5U0I4/XP_005553508.1 -
8*His
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C-term
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Protein Length
Full Length of Mature Protein
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Synonyms
C2; Complement Component 2; Complement C2; Complement Protein; C3/C5 Convertase; ARMD14; Complement Component C2; CO2
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AA Sequence
ATSCPQNVNISGGTFTLSHGWAPGSLLIYSCPQGLYPSPASRLCKSSGQWQTPRATRSLTKAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTGSRFGHGDKVRYRCSSNLVLTGSAERECQGNGVWSGTEPICRQPYSYDFPEDVAPALGTSFSHMLGATNPTQRTKESLGRKIQIQRSGHLNLYLLLDSSQSVSENDFLIFKESASLMVDRIFSFEINVSVAIITFASEPKVLMSVLNVNSRDITEVISSLENAKYKDHENGTGTNTYAALNSVYLMMNNQMQLLGMKTMAWQEIRHAIILLTDGKSNMGGSPKTAVDQIREILNINQKRNDYLDIYAIGVGKLDVDWRELNELGSKKDGERHAFILQDTKALHQVFEHMLDVSKLTDTICGVGNMSANASDQERTPWHVTIKPKSQETCRGALISDQWVLTAAHCFRDGNDHSLWRVNVGDPKSQWGKEFLIEKAVISPGFDVFAKKNQGILEFYGDDIALLKLAQKVKMSTHARPICLPCTMEANLALRRPQGSTCRDHENELLNKQSVPAHFVALNGSKLNINLKMGVEWTSCAEVVSQEKTMFPNLTDVREVVTDQFLCSGTQEDESPCKGESGGAVFLERRFRFFQVGLVSWGLYNPCLGSADKNSRKRAPRSKVPPPRDFHINLFRMQPWLRQHLGDVLNFLPL
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Predicted Molecular Mass
82.2 kDa
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Molecular Weight
Approximately 90-110 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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