PD-1/PD-L1-IN 6
PD-1/PD-L1-IN 6 (compound A13) is a potent PD-1/PD-L1 interaction inhibitor, with an IC50 of 132.8 nM. PD-1/PD-L1-IN 6 exhibits outstanding immunoregulatory activity. PD-1/PD-L1-IN 6 significantly elevates interferon-γ secretion in a Hep3B/OS-8/hPD-L1 and CD3 T cell co-culture model, without significant toxic effect. PD-1/PD-L1-IN 6 restores the immune response in a T cell-tumor co-culture model.
For research use only. We do not sell to patients.
- CAS No.: 2393983-76-9
- Formula: C25H26N2O3
- Molecular Weight:402.49
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
IC50: 132.8 ± 6.9 nM (PD-1/PD-L1 interaction)
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Jurkat | EC50 |
44.7 μM
Compound: A13
|
Cytotoxicity against human Jurkat T cells assessed as reduction in cell viability measured after 72 hrs by CCK-8 assay
Cytotoxicity against human Jurkat T cells assessed as reduction in cell viability measured after 72 hrs by CCK-8 assay
|
[PMID: 31734021] |
| Jurkat | IC50 |
38.6 μM
Compound: 1
|
Cytotoxicity against human Jurkat cells incubated for 48 hrs by CCK-8 assay
Cytotoxicity against human Jurkat cells incubated for 48 hrs by CCK-8 assay
|
[PMID: 33938739] |
| T-cell | EC50 |
0.41 μM
Compound: 1
|
Prevention of antiCD3 antibody/PD-L1-repressed mouse T cell proliferation incubated for 72 hrs by flow cytometry
Prevention of antiCD3 antibody/PD-L1-repressed mouse T cell proliferation incubated for 72 hrs by flow cytometry
|
[PMID: 33938739] |
Chemical Information
-
CAS No. 2393983-76-9
-
Molecular Weight 402.49
-
Formula C25H26N2O3
-
SMILES
O=C(C1=CC=C(CNCCO)C(OC)=C1)N2CCC3=C2C=CC=C3C4=CC=CC=C4
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)