2393983-76-9
Chemical Structure
PD-1/PD-L1-IN 6
- CAS No.: 2393983-76-9
- Formula:C25H26N2O3
- Molecular Weight:402.49
IUPAC Name: (4-(((2-hydroxyethyl)amino)methyl)-3-methoxyphenyl)(4-phenylindolin-1-yl)methanone
InChIKey: SBBYNJFHJDJZJK-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(CNCCO)C(OC)=C1)N2CCC3=C2C=CC=C3C4=CC=CC=C4
Biological Activity: PD-1/PD-L1-IN 6 (compound A13) is a potent PD-1/PD-L1 interaction inhibitor, with an IC50 of 132.8 nM. PD-1/PD-L1-IN 6 exhibits outstanding immunoregulatory activity. PD-1/PD-L1-IN 6 significantly elevates interferon-γ secretion in a Hep3B/OS-8/hPD-L1 and CD3 T cell co-culture model, without significant toxic effect. PD-1/PD-L1-IN 6 restores the immune response in a T cell-tumor co-culture model[1].
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PD-1/PD-L1-IN 6 | PD-1/PD-L1-IN 6 (compound A13) is a potent PD-1/PD-L1 interaction inhibitor, with an IC50 of 132.8 nM. PD-1/PD-L1-IN 6 exhibits outstanding immunoregulatory activity. PD-1/PD-L1-IN 6 significantly elevates interferon-γ secretion in a Hep3B/OS-8/hPD-L1 and CD3 T cell co-culture model, without significant toxic effect. PD-1/PD-L1-IN 6 restores the immune response in a T cell-tumor co-culture model. | |||||||||||||||||||||
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