MRS 1477 

MRS 1477, a dihydropyridine derivative, is a positive allosteric modulator of TRPV1 in the presence of capsaicin. MRS 1477 itself does not induce apoptosis, but the co-existence of MRS 1477 and capsaicin can induce apoptosis^[1][2].

MRS1477 evokes Ca²⁺ signals in MCF7 breast cancer cells, but not in primary breast epithelial cells^[1].
MRS1477 (2 μM; 72 h) with capsaicine (10 μM) induces apoptosis and increases reactive oxygen species production and caspase activity^[1].
MRS1477 (2 μM) increases capsaicin-evoked TRPV1-mediated current density levels^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

389.51

C₂₁H₂₇NO₄S

212200-21-0

CCOC(C1=C(C2=CC=CC=C2)NC(C)=C(C(SCCOC)=O)C1CC)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Nazıroğlu M, et, al. Targeting breast cancer cells by MRS1477, a positive allosteric modulator of TRPV1 channels. PLoS One. 2017 Jun 22;12(6):e0179950.  [Content Brief]

  [2]. Kaszas K, et, al. Small molecule positive allosteric modulation of TRPV1 activation by vanilloids and acidic pH. J Pharmacol Exp Ther. 2012 Jan;340(1):152-60.  [Content Brief]