212200-21-0
212200-21-0
Chemical Structure
MRS 1477
- CAS No.: 212200-21-0
- Formula:C21H27NO4S
- Molecular Weight:389.51
IUPAC Name: ethyl 4-ethyl-5-(((2-methoxyethyl)thio)carbonyl)-6-methyl-2-phenyl-1,4-dihydropyridine-3-carboxylate
InChIKey: DMVMFYWYJCPZGS-UHFFFAOYSA-N
SMILES: CCOC(C1=C(C2=CC=CC=C2)NC(C)=C(C(SCCOC)=O)C1CC)=O
Biological Activity: MRS 1477, a dihydropyridine derivative, is a positive allosteric modulator of TRPV1 in the presence of capsaicin. MRS 1477 itself does not induce apoptosis, but the co-existence of MRS 1477 and capsaicin can induce apoptosis[1][2].
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MRS 1477 | MRS 1477, a dihydropyridine derivative, is a positive allosteric modulator of TRPV1 in the presence of capsaicin. MRS 1477 itself does not induce apoptosis, but the co-existence of MRS 1477 and capsaicin can induce apoptosis. | |||||||||||||||||||||
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References
- [1]. Nazıroğlu M, et, al. Targeting breast cancer cells by MRS1477, a positive allosteric modulator of TRPV1 channels. PLoS One. 2017 Jun 22;12(6):e0179950. [Content Brief]
- [2]. Kaszas K, et, al. Small molecule positive allosteric modulation of TRPV1 activation by vanilloids and acidic pH. J Pharmacol Exp Ther. 2012 Jan;340(1):152-60. [Content Brief]
