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  3. Gemcitabine elaidate

Gemcitabine elaidate (Synonyms: CP-4126; CO-101; Gemcitabine 5'-elaidate)

Cat. No.: HY-13538 Purity: 99.24%
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Gemcitabine elaidate(CP-4126; CO-101) is a lipophilic, unsaturated fatty acid ester derivative of gemcitabine (dFdC), an antimetabolite deoxynucleoside analogue, with potential antineoplastic activity.

For research use only. We do not sell to patients.

Gemcitabine elaidate Chemical Structure

Gemcitabine elaidate Chemical Structure

CAS No. : 210829-30-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 146 In-stock
Estimated Time of Arrival: December 31
5 mg USD 126 In-stock
Estimated Time of Arrival: December 31
10 mg USD 174 In-stock
Estimated Time of Arrival: December 31
50 mg USD 534 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
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Based on 1 publication(s) in Google Scholar

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Description

Gemcitabine elaidate(CP-4126; CO-101) is a lipophilic, unsaturated fatty acid ester derivative of gemcitabine (dFdC), an antimetabolite deoxynucleoside analogue, with potential antineoplastic activity. IC50 value: Target: Gemcitabine analog Upon hydrolysis intracellularly by esterases, the prodrug gemcitabine is converted into the active metabolites difluorodeoxycytidine di- and tri-phosphate (dFdCDP and dFdCTP) by deoxycytidine kinase. dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis. Due to its lipophilicity, gemcitabine 5'-elaidic acid ester exhibits an increased cellular uptake and accumulation, resulting in an increased conversion to active metabolites, compared to gemcitabine. In addition, this formulation of gemcitabine may be less susceptible to deamination and deactivation by deoxycytidine deaminase. Check for active clinical trials or closed clinical trials using this agent.

Clinical Trial
Molecular Weight

527.64

Formula

C₂₇H₄₃F₂N₃O₅

CAS No.

210829-30-4

SMILES

O[[email protected]@H](C(F)(F)[[email protected]](N1C(N=C(C=C1)N)=O)O2)[[email protected]]2COC(CCCCCCC/C=C/CCCCCCCC)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 26 mg/mL (49.28 mM)

*"≥" means soluble, but saturation unknown.

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Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8952 mL 9.4762 mL 18.9523 mL
5 mM 0.3790 mL 1.8952 mL 3.7905 mL
10 mM 0.1895 mL 0.9476 mL 1.8952 mL
*Please refer to the solubility information to select the appropriate solvent.

Purity: 99.24%

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Gemcitabine elaidate
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