1. Cell Cycle/DNA Damage
    Metabolic Enzyme/Protease
  2. HSP
    DNA/RNA Synthesis
  3. 116-9e

116-9e (Synonyms: MAL2-11B)

Cat. No.: HY-116683
Handling Instructions

116-9e (MAL2-11B) is a Hsp70 co-chaperone DNAJA1 inhibitor. 116-9e inhibits Simian Virus 40 (SV40) replication and DNA synthesis. 116-9e inhibits tumor antigen (TAg)’s endogenous ATPase activity and the TAg-mediated activation of Hsp70.

For research use only. We do not sell to patients.

116-9e Chemical Structure

116-9e Chemical Structure

CAS No. : 831217-43-7

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Description

116-9e (MAL2-11B) is a Hsp70 co-chaperone DNAJA1 inhibitor. 116-9e inhibits Simian Virus 40 (SV40) replication and DNA synthesis. 116-9e inhibits tumor antigen (TAg)’s endogenous ATPase activity and the TAg-mediated activation of Hsp70[1][2].

IC50 & Target

Simian Virus 40 (SV40) [1]
Hsp70 co-chaperone DNAJA1[2]

In Vitro

116-9e (MAL2-11B) inhibits TAg stimulation of Hsp70 with greater efficacy than MAL3-101, significantly reduces viral replication and DNA synthesis. MAL2-11B also inhibits the activity of the TAg ATPase domain[1].
116-9e (MAL2-11B; 15 µM; 5 days) significantly reduces the growth of BK virus in a human kidney cell line[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

512.60

Formula

C₃₁H₃₂N₂O₅

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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116-9e
Cat. No.:
HY-116683
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