Sorbitan monopalmitate 

Sorbitan monopalmitate is a food-grade, non-ionic emulsifier that exhibits oral activity. Sorbitan monopalmitate functions as a crystallization modifier, promoting the aggregation of spherical mango butter crystals, introducing lattice defects, and regulating the crystallization rate of mango butter. Sorbitan monopalmitate serves as a component of precursor vesicle gels, enabling the controlled and sustained release of drugs and facilitating the preparation of stable transdermal delivery formulations^[1][2][3][4].

Sorbitan monopalmitate (0-5% w/w; 30 min) modulates the color properties of mango butter formulations. Compared with the group supplemented with 1% w/w Sorbitan monopalmitate, supplementation with 5% w/w Sorbitan monopalmitate reduces yellowness and increases whiteness^[2].
Sorbitan monopalmitate (1-5% w/w; 30 min) promotes the aggregation of spherical mango fat crystals and forms a denser fat crystal network, thereby modulating the crystal structure of mango fat^[2].
Sorbitan monopalmitate (1-5% w/w; 5 h) improves the mechanical stability of mango butter formulations^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sorbitan monopalmitate (E 495) (25 mg/kg; p.o.; continuously administered via diet daily; 2 years) produces no observable adverse effects on growth, survival, hematological parameters, or organ histopathology in male rats over their 2-year lifespan^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

26266-57-9

Solid

White to off-white

O=C(CCCCCCCCCCCCCCC)OC[C@H]([C@@H]1[C@@H]([C@H](CO1)O)O)O

Room temperature in continental US; may vary elsewhere.

Store at room temperature, keep dry and cool

• [1]. EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS), et al. Re-evaluation of sorbitan monostearate (E 491), sorbitan tristearate (E 492), sorbitan monolaurate (E 493), sorbitan monooleate (E 494) and sorbitan monopalmitate (E 495) when used as food additives. EFSA J. 2017;15(5):e04788. Published 2017 May 5.  [Content Brief]

  [2]. Das P, et al. Effect of sorbitan monopalmitate on the polymorphic transitions and physicochemical properties of mango butter. Food Chem. 2021;347:128987.

  [3]. Varshosaz J, et al. Sorbitan monopalmitate-based proniosomes for transdermal delivery of chlorpheniramine maleate. Drug Deliv. 2005;12(2):75-82.

  [4]. BELL JT Jr, et al. Polyoxyethylene sorbitan monopalmitate (tween 40) as a vehicle for oil red O fat stain. Stain Technol. 1959 Jul;34(4):219-21.