B7H3/ICOSL Antibody (YA3064)
(Synonyms: inducible T-cell co-stimulator ligand; B7H2; GL50; B7-H2; B7RP1; CD275; ICOSL; LICOS; B7RP-1; ICOS-L)B7H3/ICOSL Antibody (YA3064) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to B7H3/ICOSL.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IP
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Reactivity :
Human
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Formulation:
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IP
IP: Immunoprecipitation
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|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:20 |
Product Details
B7H3/ICOSL Antibody (YA3064) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to B7H3/ICOSL.
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Host Rabbit
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Clonality Recombinant, Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 75 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 33 kDa
Recombinant protein of human ICOS Ligand
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
B7H3/ICOSL is a Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion. Also induces B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function. In endothelial cells, required for proper neutrophil transmigration in response to chemoattractants, such as CXCL8/IL8 or N-formyl-methionyl peptides (fMLP)[1][2][3].
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Subcellular Localization
Cell membrane; Single-pass type I membrane protein; Cell membrane
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Expression
Tissue_specificity:It is expressed (protein level) on peripheral blood B cells and monocytes, as well as dendritic cells derived from monocytes; it is widely expressed in the brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, bone marrow, colon, ovary, prostate, testis, lymph nodes, leukocytes, spleen, thymus, and tonsils; it is detected only in lymph nodes, leukocytes, and spleen. It is expressed on activated monocytes and dendritic cells.
Induction:Constitutive expression is up-regulated by treatment with TNF in peripheral blood B-cells and monocytes, while it is decreased in dendritic cells (PubMed:11007762) . In monocytes, up-regulated by CCL3/macrophage inflammatory protein 1-alpha and IFNG (PubMed:10779774) -
Isoforms & Post-Translational Modification
O75144 has 3 isomers: O75144-1: 33349 Da (predicted); O75144-2: 34225 Da (predicted); O75144-3: 20120 Da (predicted).
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Subunit
Interacts with CTLA4 (in vitro)
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SwissProt ID
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Synonyms
inducible T-cell co-stimulator ligand; B7H2; GL50; B7-H2; B7RP1; CD275; ICOSL; LICOS; B7RP-1; ICOS-L
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Research Field
Immunology
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