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  3. Primary Antibodies
  4. Monoclonal Antibodies Recombinant Antibodies
  5. B7H3/ICOSL Antibody (YA3064)

B7H3/ICOSL Antibody (YA3064)

Cat. No.: HY-P83319
User Guide for Antibodies Technical Support

B7H3/ICOSL Antibody (YA3064) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to B7H3/ICOSL.

For research use only. We do not sell to patients.

Size Price Stock Quantity
20 μL Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
50 μL Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
100 μL Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
250 μL   Get quote  
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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Documentation

Description

B7H3/ICOSL Antibody (YA3064) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to B7H3/ICOSL.
Host

Rabbit
Clonality

Recombinant, Monoclonal
Molecular Weight
Predicted band size: 33 kDa;
Observed band size: 75 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human
SwissProt ID
Gene ID
Immunogen

Recombinant protein of human ICOS Ligand
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:500-1:1000
IP
IP: Immunoprecipitation
1:20
Sensitivity Endogenous Purity Affinity Purified
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Background
Function：Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion (PubMed:11007762, PubMed:11023515, PubMed:30498080). Also induces B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (By similarity). In endothelial cells, required for proper neutrophil transmigration in response to chemoattractants, such as CXCL8/IL8 or N-formyl-methionyl peptides (fMLP) (PubMed:30498080)
Subcellular Localization：Cell membrane; Single-pass type I membrane protein; Cell membrane
Expression：
Tissue_specificity:It is expressed (protein level) on peripheral blood B cells and monocytes, as well as dendritic cells derived from monocytes; it is widely expressed in the brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, bone marrow, colon, ovary, prostate, testis, lymph nodes, leukocytes, spleen, thymus, and tonsils; it is detected only in lymph nodes, leukocytes, and spleen. It is expressed on activated monocytes and dendritic cells.

Induction:Constitutive expression is up-regulated by treatment with TNF in peripheral blood B-cells and monocytes, while it is decreased in dendritic cells (PubMed:11007762) . In monocytes, up-regulated by CCL3/macrophage inflammatory protein 1-alpha and IFNG (PubMed:10779774)
Isoforms & Post-Translational Modification：O75144 has 3 isomers: O75144-1: 33349 Da (predicted); O75144-2: 34225 Da (predicted); O75144-3: 20120 Da (predicted).
Subunit：Interacts with CTLA4 (in vitro)
Database

Entrez Gene: 23308 Human

SwissProt: O75144 Human

OMIM: 620825 Human

Research Field

Immunology
Synonyms
inducible T-cell co-stimulator ligand; B7H2; GL50; B7-H2; B7RP1; CD275; ICOSL; LICOS; B7RP-1; ICOS-L
Documentation
User Guide for Antibodies (1077 KB)

B7H3/ICOSL Antibody (YA3064) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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