ICOSLG - inducible T cell costimulator ligand Gene
Also Known as B7h; B7H2; GL50; B7-H2; B7RP1; CD275; ICOSL; LICOS; B7RP-1; ICOS-L
Species: Homo sapiens
About ICOSLG
This gene has 17 transcripts (splice variants), 124 orthologues and 15 paralogues. Ubiquitous expression in brain (RPKM 4.2), lymph node (RPKM 3.4) and 23 other tissues.
Summary
Enables identical protein binding activity. Predicted to be involved in T cell receptor signaling pathway and positive regulation of interleukin-4 production. Located in cytoplasmic ribonucleoprotein granule and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
ICOSLG Products (6)
| mRNA | Protein | Name |
|---|---|---|
| NM_001283050.2 | NP_001269979.1 | ICOS ligand isoform b precursor |
| NM_001283051.2 | NP_001269980.1 | ICOS ligand isoform c precursor |
| NM_001283052.2 | NP_001269981.1 | ICOS ligand isoform d |
| NM_001365759.2 | NP_001352688.1 | ICOS ligand isoform e |
| NM_001395918.1 | NP_001382847.1 | ICOS ligand isoform f precursor |
| NM_015259.6 | NP_056074.1 | ICOS ligand isoform a precursor |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables identical protein binding |
IPI
IPI: Inferred from physical interaction
|
16951355 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
11956294 | GOA |
ICOSLG Protein Structure
V-set: Immunoglobulin V-set domain (20 - 124)
C2-set_2: CD80-like C2-set immunoglobulin domain (151 - 224)
- 0
- 100
- 200
- 300
- 400
- 473 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
ICOS ligand |
|
Recombinant ICOSLG Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P7324 | B7-H2/ICOSLG Protein, Human (HEK293, Fc) | O75144-1 (D19-S258) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P7325 | B7-H2/ICOSLG Protein, Human (HEK293, His) | O75144-1 (D19-S258) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P78075 | B7-H2/ICOSLG Protein, Human (Biotinylated, HEK293, His-Avi) | O75144-1 (D19-S258) | ≥ 95%, as determined by Bis-Tris PAGE. |
| HY-P78392 | B7-H2/ICOSLG Protein, Human (HEK293, His-Avi) | O75144-1 (D19-S258) | ≥ 95%, as determined by Bis-Tris PAGE. |
ICOSLG Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P81706 | B7H2/ICOSL Antibody (YA1451) | FC, ELISA | Human |
| HY-P83319 | B7H3/ICOSL Antibody (YA3064) | WB, IP | Human |
| HY-P83319A | B7H3/ICOSL Antibody (YA3064)(PBS only) | WB, IP | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Combined Immunodeficiency |
|
|
| Respiratory Allergy |
|
|
| Cd40 Ligand Deficiency |
|
|
| Chronic Asthma |
|
|
| Autoimmune Disease Of Exocrine System |
|
|
| Autoimmune Disease Of Musculoskeletal System |
|
|
| Bone Inflammation Disease |
|
|
| Systemic Scleroderma |
|
|
| Integumentary System Disease |
|
|
| Primary Thrombocytopenia |
|
|
| Autoimmune Disease Of Central Nervous System |
|
|
| Leukocyte Disease |
|
|
| Parasitic Helminthiasis Infectious Disease |
|
|
| Autoimmune Disease Of Skin And Connective Tissue |
|
|
| Combined T And B Cell Immunodeficiency |
|
|
| Acute Asthma |
|
|
| Autoimmune Disease Of Gastrointestinal Tract |
|
|
| Autoimmune Disease Of Endocrine System |
|
|
| Autoimmune Peripheral Neuropathy |
|
|
| B Cell Deficiency |
|
|
| Bronchial Disease |
|
|
| Primary Bacterial Infectious Disease |
|
|
| Nose Disease |
|
|
| Nasal Cavity Disease |
|
|
| Autoimmune Cardiomyopathy |
|
|
| Thymic Dysplasia |
|
|
| Persistent Severe Asthma |
|
|
| Hypersensitivity Reaction Type Iv Disease |
|
|
| Immunodeficiency 16 |
|
|
| Immune System Disease |
|
|
| Exanthem |
|
|
| Inflammatory Bowel Disease 5 |
|
|
| Trichinosis |
|
|
| Salivary Gland Disease |
|
|
| Childhood Type Dermatomyositis |
|
|
| Parasitic Protozoa Infectious Disease |
|
|
| Autoimmune Myocarditis |
|
|
| Near-Fatal Asthma |
|
|
| Immune-Complex Glomerulonephritis |
|
|
| Lacrimal Apparatus Disease |
|
|
| Igg4-Related Disease |
|
|
| Autoimmune Disease Of Cardiovascular System |
|
|
| Upper Respiratory Tract Disease |
|
|
| Autoimmune Disease Of Blood |
|
|
| Immunodysregulation, Polyendocrinopathy, And Enteropathy, X-Linked |
|
|
| Respiratory System Disease |
|
|
| Angioimmunoblastic T-Cell Lymphoma |
|
|
| Skin Carcinoma |
|
|
| Uveal Disease |
|
|
| Autoimmune Glomerulonephritis |
|
|
| Monoclonal Gammopathy Of Uncertain Significance |
|
|
| Immunodeficiency 13 |
|
|
| T Cell Deficiency |
|
|
| Immunodeficiency 20 |
|
|
| Alopecia Areata |
|
|
| Intestinal Schistosomiasis |
|
|
| Autoimmune Disease Of Peripheral Nervous System |
|
|
| Thymus Gland Disease |
|
|
| Lymphatic System Disease |
|
|
| Potocki-Shaffer Syndrome |
|
|
| Lymphatic System Cancer |
|
|
| Extrinsic Cardiomyopathy |
|
|
| Immunodeficiency With Hyper-Igm, Type 3 |
|
|
| Intestinal Disease |
|
|
| Autoimmune Disease Of Eyes, Ear, Nose And Throat |
|
|
| Immunodeficiency 14 |
|
|
| Bone Marrow Cancer |
|
|
| Disease By Infectious Agent |
|
|
| Mikulicz Disease |
|
|
| Endocrine System Disease |
|
|
| Carbohydrate Metabolic Disorder |
|
|
| Immunodeficiency With Hyper-Igm, Type 1 |
|
|
| Commensal Bacterial Infectious Disease |
|
|
| Autoimmune Neuropathy |
|
|
| Psoriasis 12 |
|
|
| Sialadenitis |
|
|
| Urinary System Disease |
|
|
| Dacryoadenitis |
|
|
| Glucose Metabolism Disease |
|
|
| Lichen Disease |
|
|
| Malignant Ovarian Surface Epithelial-Stromal Neoplasm |
|
|
| Crescentic Glomerulonephritis |
|
|
| Acute Proliferative Glomerulonephritis |
|
|
| Ovary Epithelial Cancer |
|
|
| Immunoglobulin Alpha Deficiency |
|
|
| Listeriosis |
|
|
| Blood Protein Disease |
|
|
| Cutaneous Lupus Erythematosus |
|
|
| Chronic Conjunctivitis |
|
|
| Progressive Multifocal Leukoencephalopathy |
|
|
| Autoimmune Uveitis |
|
|
| Gastrointestinal System Disease |
|
|
| Chromosomal Deletion Syndrome |
|
|
| Inherited Metabolic Disorder |
|
|
| Polyclonal Hypergammaglobulinemia |
|
|
| Polyradiculopathy |
|
|
| Myositis |
|
|
| Rhinitis |
|
|
| Autoimmune Disease Of Urogenital Tract |
|
|
| Coccidiosis |
|
|
| Autoimmune Pancreatitis |
|
|
| Legume Allergy |
|
|
| Bardet-Biedl Syndrome 2 |
|
|
| Human Papillomavirus Infectious Disease |
|
|
| Mature T-Cell And Nk-Cell Lymphoma |
|
|
| Chronic Inflammatory Demyelinating Polyradiculoneuropathy |
|
|
| Thrombocytopenia Due To Platelet Alloimmunization |
|
|
| Smoldering Myeloma |
|
|
| Common Cold |
|
|
| Interstitial Nephritis |
|
|
| Progressive Relapsing Multiple Sclerosis |
|
|
| Contact Dermatitis |
|
|
| Dry Eye Syndrome |
|
|
| Thyroid Gland Disease |
|
|
| Primary Progressive Multiple Sclerosis |
|
|
| Autoimmune Polyendocrine Syndrome |
|
|
| Allergic Disease |
|
|
| Malignant Exocrine Pancreas Neoplasm |
|
|
| Selective Immunoglobulin Deficiency Disease |
|
|
| Urinary Schistosomiasis |
|
|
| Thrombocytopenic Purpura, Autoimmune |
|
|
| Keratoconjunctivitis Sicca |
|
|
| Lymph Node Disease |
|
|
| Endocervical Carcinoma |
|
|
| Peanut Allergy |
|
|
| Fruit Allergy |
|
|
| Mature B-Cell Neoplasm |
|
|
| Nontoxic Goiter |
|
|
| Proliferative Glomerulonephritis |
|
|
| Sensory System Disease |
|
|
| Graves' Disease |
|
|
| Thymus Cancer |
|
|
| Short Syndrome |
|
|
| Female Reproductive System Disease |
|
|
| Secondary Progressive Multiple Sclerosis |
|
|
| Demyelinating Disease |
|
|
| Central Nervous System Disease |
|
|
| Sclerosing Cholangitis |
|
|
| Spinal Cord Disease |
|
|
| Panuveitis |
|
|
| Agammaglobulinemia, X-Linked |
|
|
| Head And Neck Cancer |
|
|
| Xerophthalmia |
|
|
| Colonic Disease |
|
|
| Anemia, Autoimmune Hemolytic |
|
|
| Colitis |
|
|
| Bullous Skin Disease |
|
|
| Thoracic Cancer |
|
|
| Uterine Body Mixed Cancer |
|
|
| Herpangina |
|
|
| Allergic Contact Dermatitis |
|
|
| Pollen Allergy |
|
|
| Allergic Conjunctivitis |
|
|
| Capillary Disease |
|
|
| Hypersensitivity Vasculitis |
|
|
| Dysgammaglobulinemia |
|
|
| Chromosomal Disease |
|
|
| Blood Coagulation Disease |
|
|
| Large Intestine Cancer |
|
|
| Muscular Disease |
|
|
| Crohn'S Disease |
|
|
| Agammaglobulinemia |
|
|
| Immune Deficiency Disease |
|
|
| Hypersensitivity Reaction Type Iii Disease |
|
|
| Celiac Disease 1 |
|
|
| Reproductive System Disease |
|
|
| Connective Tissue Cancer |
|
|
| Fungal Infectious Disease |
|
|
| Food Allergy |
|
|
| Ovarian Cystadenocarcinoma |
|
|
| Autoimmune Polyendocrine Syndrome Type 1 |
|
|
| Henoch-Schoenlein Purpura |
|
|
| Hematologic Cancer |
|
|
| Spinal Disease |
|
|
| Anterior Uveitis |
|
|
| Muscle Tissue Disease |
|
|
| Paranasal Sinus Disease |
|
|
| Sjogren Syndrome |
|
|
| Vogt-Koyanagi-Harada Disease |
|
|
| Spondyloarthropathy 1 |
|
|
| Respiratory System Cancer |
|
|
| Pancreas Disease |
|
|
| Immunodeficiency With Hyper-Igm, Type 2 |
|
|
| Cranial Nerve Disease |
|
|
| T2-High Asthma |
|
|
| Capillary Leak Syndrome |
|
|
| Renal Cell Carcinoma, Nonpapillary |
|
|
| Posterior Uveitis |
|
|
| Opportunistic Mycosis |
|
|
| Brain Glioma |
|
|
| Malaria |
|
|
| Erysipelas |
|
|
| Chromophobe Renal Cell Carcinoma |
|
|
| Colorectal Cancer |
|
|
| Vitiligo-Associated Multiple Autoimmune Disease Susceptibility 1 |
|
|
| Conjunctival Disease |
|
|
| Connective Tissue Disease |
|
|
| Spondyloarthropathy |
|
|
| Asthma |
|
|
| Sarcoidosis 1 |
|
|
| Autoimmune Gastritis |
|
|
| Lymphoma, Non-Hodgkin, Familial |
|
|
| Central Nervous System Cancer |
|
|
| Marginal Zone B-Cell Lymphoma |
|
|
| Male Reproductive Organ Cancer |
|
|
| Juvenile Rheumatoid Arthritis |
|
|
| Gastrointestinal System Cancer |
|
|
| Hashimoto Thyroiditis |
|
|
| Pemphigus Vulgaris, Familial |
|
|
| Bladder Disease |
|
|
| Malignant Astrocytoma |
|
|
| Bile Duct Disease |
|
|
| Acquired Metabolic Disease |
|
|
| Blood Platelet Disease |
|
|
| Bacterial Infectious Disease |
|
|
| Autoimmune Lymphoproliferative Syndrome |
|
|
| Arteries, Anomalies Of |
|
|
| Male Reproductive System Disease |
|
|
| Bone Disease |
|
|
| Adult T-Cell Leukemia/Lymphoma |
|
|
| Endocervical Adenocarcinoma |
|
|
| Viral Infectious Disease |
|
|
| Merkel Cell Carcinoma |
|
|
| Relapsing-Remitting Multiple Sclerosis |
|
|
| Biliary Tract Disease |
|
|
| Lymphoma, Hodgkin, Classic |
|
|
| Bare Lymphocyte Syndrome, Type Ii |
|
|
| Optic Nerve Disease |
|
|
| Lung Cancer |
|
|
| Omenn Syndrome |
|
|
| Autonomic Nervous System Neoplasm |
|
|
| Immunodeficiency 35 |
|
|
| Gastric Lymphoma |
|
|
| Periapical Periodontitis |
|
|
| Hyper Ige Syndrome |
|
|
| Peripheral Nervous System Neoplasm |
|
|
| Breast Disease |
|
|
| Human Immunodeficiency Virus Infectious Disease |
|
|
| Skin Disease |
|
|
| West Nile Encephalitis |
|
|
| Common Variable Immunodeficiency |
|
|
| Skin Melanoma |
|
|
| Peripheral Nervous System Disease |
|
|
| Lymphadenitis |
|
|
| Uterine Corpus Cancer |
|
|
| Bacterial Sepsis |
|
|
| Systemic Lupus Erythematosus |
|
|
| Lymphoma, Mucosa-Associated Lymphoid Type |
|
|
| Ovarian Serous Cystadenocarcinoma |
|
|
| Behcet Syndrome |
|
|
| Esophageal Disease |
|
|
| Endocrine Gland Cancer |
|
|
| Interstitial Lung Disease |
|
|
| Prostate Disease |
|
|
| Uterine Carcinosarcoma |
|
|
| Suppression Of Tumorigenicity 12 |
|
|
| Peripheral T-Cell Lymphoma |
|
|
| Dermatitis, Atopic |
|
|
| Coronavirus Infectious Disease |
|
|
| Myxofibrosarcoma |
|
|
| Pernicious Anemia |
|
|
| Kidney Cancer |
|
|
| Esophageal Cancer |
|
|
| Mast Cell Neoplasm |
|
|
| Bone Cancer |
|
|
| Pleural Cancer |
|
|
| Overnutrition |
|
|
| Adrenal Cortex Disease |
|
|
| Stomach Disease |
|
|
| Autoimmune Disease |
|
|
| Psoriatic Arthritis |
|
|
| Cholangitis, Primary Sclerosing |
|
|
| Nervous System Disease |
|
|
| Central Nervous System Vasculitis |
|
|
| Ovary Adenocarcinoma |
|
|
| Plasma Protein Metabolism Disease |
|
|
| Bacterial Pneumonia |
|
|
| Esophagitis, Eosinophilic, 1 |
|
|
| Diffuse Large B-Cell Lymphoma |
|
|
| Chronic Mucocutaneous Candidiasis |
|
|
| Nail Disease |
|
|
| Mycobacterium Tuberculosis 1 |
|
|
| Langerhans Cell Histiocytosis |
|
|
| Primary Biliary Cholangitis |
|
|
| Bile Duct Adenocarcinoma |
|
|
| Phenylketonuria |
|
|
| Pulmonary Disease, Chronic Obstructive |
|
|
| Rectal Disease |
|
|
| Eye Disease |
|
|
| Cervix Carcinoma |
|
|
| Cervix Disease |
|
|
| Mantle Cell Lymphoma |
|
|
| Pancreatic Ductal Adenocarcinoma |
|
|
| Granulomatosis With Polyangiitis |
|
|
| Type 1 Diabetes Mellitus |
|
|
| Amino Acid Metabolic Disorder |
|
|
| Cardiovascular System Disease |
|
|
| Leukemia, Acute Myeloid |
|
|
| Trypanosomiasis |
|
|
| Interstitial Lung Disease 2 |
|
|
| Ovarian Cancer |
|
|
| Pancreatic Cancer |
|
|
| Lung Squamous Cell Carcinoma |
|
|
| Brain Cancer |
|
|
| Severe Combined Immunodeficiency |
|
|
| Melanoma, Uveal |
|
|
| Adrenal Cortical Carcinoma |
|
|
| Plasma Cell Neoplasm |
|
|
| Squamous Cell Carcinoma, Head And Neck |
|
|
| Leukemia, Acute Lymphoblastic |
|
|
| Inflammatory Bowel Disease |
|
|
| Myeloma, Multiple |
|
|
| Deficiency Anemia |
|
|
| Basal Cell Carcinoma |
|
|
| Leukemia, Chronic Lymphocytic |
|
|
| Breast Cancer |
|
|
| T-Cell Acute Lymphoblastic Leukemia |
|
|
| Wilms Tumor 1 |
|
|
| Body Mass Index Quantitative Trait Locus 11 |
|
|
| Dilated Cardiomyopathy |
|
|
| Myelodysplastic Syndrome |
|
|
| Leukemia, Chronic Myeloid |
|
|
| Myopathy |
|
|
| Type 2 Diabetes Mellitus |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | ICOSLG | MGD | MGI:1354701 |
| Rattus norvegicus | ICOSLG | RGD | RGD:1562791 |