Poloxamer 181 (L61)  (Synonyms: PEG-PPG-PEG, 2000 (Average))

Poloxamer 181 L61 is a block polymer of polyethylene oxide and polypropylene oxide with an average molecular weight of 2000. Poloxamer has the ability to inhibit P-gp. Poloxamer 181 has antimicrobial activity and can inhibit Mycobacterium avium. Poloxamer 181 can form a thermally reversible hydrogel and is used as a food additive, and as an agent delivery carrier in cosmetics, pharmaceuticals and tissue engineering^[1][2][3].

Poloxamer 181 (1 mg/mL) inhibits 91% of Mycobacterium avium^[1].
Poloxamers have the ability to inhibit P-gp^[3].
Poloxamers have been proposed as agent carriers to improve efficacy and reduce side effects^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Poloxamer 181 (p.o. via diet) has little effect on the ACF number in the rats, as compared to controls^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2000 (Average)

9003-11-6

Liquid (Density: 1.095 g/cm³)

Colorless to light yellow

[Poloxamer 181 (L61)]

Room temperature in continental US; may vary elsewhere.

Store at room temperature 3 years

• [1]. Singh-Joy SD, et al., Safety assessment of poloxamers 101, 105, 108, 122, 123, 124, 181, 182, 183, 184, 185, 188, 212, 215, 217, 231, 234, 235, 237, 238, 282, 284, 288, 331, 333, 334, 335, 338, 401, 402, 403, and 407, poloxamer 105 benzoate, and poloxamer 182 dibenzoate as used in cosmetics. Int J Toxicol. 2008;27 Suppl 2:93-128.  [Content Brief]

  [2]. Hunter RL, et al., Enhancement of antibiotic susceptibility and suppression of Mycobacterium avium complex growth by poloxamer 331. antimicrob Agents Chemother. 1995 Feb;39(2):435-9.  [Content Brief]

  [3]. Mello JC, et al. Enhancement of chlorpromazine antitumor activity by Pluronics F127/L81 nanostructured system against human multidrug resistant leukemia. Pharmacol Res. 2016 Sep;111:102-112.  [Content Brief]