PLGA-PEG-MAL (20kDA-5.0kDA, LA:GA ratio 50:50)
Based on 1 publication(s) in Google Scholar
PLGA-PEG-MAL (20kDA-5.0kDA, LA:GA ratio 50:50) is a degradable amphiphilic polymer nanocarrier of poly (lactic acid-co-glycolic acid)-block-poly (ethylene glycol) (PLGA-PEG-Mal) that allows covalent modification of functional molecules. PLGA-PEG-MAL (20kDA-5.0kDA, LA:GA ratio 50:50) serves as a core polymer for nanoparticle synthesis, and also acts as a nanoparticle component for site-specific antibody conjugation to construct artificial antigen-presenting cells. PLGA-PEG-MAL (20kDA-5.0kDA, LA:GA ratio 50:50) is applicable for drug delivery-related research.
For research use only. We do not sell to patients.
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Storage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) PLGA-PEG-MAL (20kDA-5.0kDA, LA:GA ratio 50:50)
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Biological Activity
Description
In Vitro
PLGA-PEG-MAL (20 kDa-5.0 kDa, LA:GA ratio 50:50) nanoparticles conjugated with MECA79 and anti-CD3 antibodies exhibit a stable spherical morphology, sustain the in vitro release of anti-CD3 monoclonal antibodies for up to one week, and possess long-term stability in NOD mouse plasma[1].
PLGA-PEG-MAL (20 kDa-5.0 kDa, LA:GA ratio 50:50)-modified artificial antigen-presenting cells (NP-Mal low and NP-Mal high) induce weaker calcium influx in human CD8+ T cells compared with azide-functionalized nanoparticles and boost granzyme B secretion[2].
PLGA-PEG-MAL (20kDA-5.0kDA, LA:GA ratio 50:50)-based aAPCs (NP-Mal low and NP-Mal high) modulate CD8+ T cell phenotype at a concentration of 200 μg/mL, with NP-Mal high promoting a more differentiated, central memory phenotype and NP-Mal low promoting a more effector memory phenotype[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Oil
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Color White to off-white
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SMILES
O=C(C=CC1=O)N1CCC(OCCOCC(COCC(C(O[H])C)=O)=O)=O.[x].[y]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Adv Sci (Weinh)
Targeting the SOX9/TIMP1 Axis with iRGD-Conjugated Nanoplatform Enhances Dendritic Cell Function and Photodynamic Immunotherapy in Gastric Cancer. [Abstract]2025 Nov 21:e10500. PMID: 41270217
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PLGA-PEG-MAL (20kDA-5.0kDA, LA:GA ratio 50:50) Related Classifications
HY-148776 Related Classifications
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Keywords
- PLGA-PEG-MAL (20kDA-5.0kDA, LA:GA ratio 50:50)
- Biochemical Assay Reagents
- artificial antigen-presenting cells
- Granzyme B
- PLNs
- poly(d,l-lactic-co-glycolic) acid-polyethylene glycol block copolymer
- clathrin-mediated internalization
- human CD8+ T cells
- nanoparticle synthesis
- type 1 diabetes
- NOD mice
- inflamed pancreata
- Inhibitor
- inhibitor
- inhibit