rel-Biotin-d₄  (Synonyms: rel-Vitamin B7-d₄; rel-Vitamin H-d₄; rel-D-Biotin-d₄)

rel-Biotin-d₄ is the deuterium labeled Biotin. Biotin is an enzyme co-factor present in minute amounts in every living cell.

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

248.34

C₁₀H₁₂D₄N₂O₃S

1217850-77-5

Solid

White to off-white

OC(CC([2H])([2H])C([2H])([2H])C[C@H]1[C@]2([H])[C@@](CS1)([H])NC(N2)=O)=O

Room temperature in continental US; may vary elsewhere.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.  [Content Brief]

  [2]. Zempleni, J. and D.M. Mock, Biotin biochemistry and human requirements. J Nutr Biochem, 1999. 10(3): p. 128-38.  [Content Brief]

  [3]. Mock, D.M., Biotin status: which are valid indicators and how do we know? J Nutr, 1999. 129(2S Suppl): p. 498S-503S.  [Content Brief]