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antitumor+properties

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Aldose Reductase (1) Antibiotic (1) Antibody-Drug Conjugates (ADCs) (2) Apoptosis (3) Bacterial (5) Biochemical Assay Reagents (1) Drug-Linker Conjugates for ADC (1) EGFR (2) Endogenous Metabolite (4) Environmental Pollutants (1) Estrogen Receptor/ERR (1) Fatty Acid Synthase (FASN) (2) Fungal (3) HCV (1) Interleukin Related (3) Keap1-Nrf2 (1) Mitochondrial Metabolism (1) MMP (1) Potassium Channel (1) PROTACs (1) Reactive Oxygen Species (ROS) (4) Reference Standards (4) RET (1) STAT (2) TNF Receptor (3) Topoisomerase (1) VEGFR (1)
By Research Areas:	Cancer (23) Cardiovascular Disease (2) Infection (5) Inflammation/Immunology (9) Neurological Disease (3)

By Targets:

Aldose Reductase (1)

Antibiotic (1)

Antibody-Drug Conjugates (ADCs) (2)

Apoptosis (3)

Bacterial (5)

Biochemical Assay Reagents (1)

Drug-Linker Conjugates for ADC (1)

EGFR (2)

Endogenous Metabolite (4)

Environmental Pollutants (1)

Estrogen Receptor/ERR (1)

Fatty Acid Synthase (FASN) (2)

Fungal (3)

HCV (1)

Interleukin Related (3)

Keap1-Nrf2 (1)

Mitochondrial Metabolism (1)

MMP (1)

Potassium Channel (1)

PROTACs (1)

Reactive Oxygen Species (ROS) (4)

Reference Standards (4)

RET (1)

STAT (2)

TNF Receptor (3)

Topoisomerase (1)

VEGFR (1)

By Research Areas:

Cancer (23)

Cardiovascular Disease (2)

Infection (5)

Inflammation/Immunology (9)

Neurological Disease (3)

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-14944

Homoharringtonine Maximum Cited Publications 35 Publications Verification Omacetaxine mepesuccinate; HHT	STAT	Cancer
Homoharringtonine (Omacetaxine mepesuccinate;HHT) is a cytotoxic alkaloid with antitumor properties which acts by inhibiting translation elongation.

HY-14452

Fatostatin Maximum Cited Publications 52 Publications Verification 125B11	Fatty Acid Synthase (FASN)	Cancer
Fatostatin (125B11), a specific inhibitor of SREBP activation, impairs the activation of SREBP-1 and SREBP-2. Fatostatin binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs. Fatostatin decreases the transcription of lipogenic genes in cells. Fatostatin possesses antitumor properties, and lowers hyperglycemia in ob/ob mice .

HY-P9921

Trastuzumab emtansine 5+ Cited Publications Ado-Trastuzumab emtansine; PRO132365; T-DM 1	Antibody-Drug Conjugates (ADCs) EGFR	Cancer
Trastuzumab emtansine (Ado-Trastuzumab emtansine) is an antibody-drug conjugate (ADC) that incorporates the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of the microtubule-inhibitory agent DM1 (HY-19792). Trastuzumab emtansine can be used for the research of advanced breast cancer .

HY-P9921A

Trastuzumab emtansine (solution) 5+ Cited Publications Ado-Trastuzumab emtansine (solution); PRO132365 (solution); T-DM 1 (solution)	Antibody-Drug Conjugates (ADCs) EGFR	Cancer
Trastuzumab emtansine (Ado-Trastuzumab emtansine) is an antibody-drug conjugate (ADC) that incorporates the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of the microtubule-inhibitory agent DM1 (derivative of maytansine), and the drug-linker conjugate for ADC is SMCC-DM1 (HY-101070). Trastuzumab emtansine can be used for the research of advanced breast cancer .

HY-N0512

Loganin 5 Publications Verification Loganoside	Reactive Oxygen Species (ROS) TNF Receptor Interleukin Related	Neurological Disease Inflammation/Immunology Cancer
Loganin is a type of iridoid glycoside compound that possesses anti-inflammatory, antioxidant, and antitumor properties, and offers protective effects against acute lung injury and pulmonary fibrosis. Loganin exerts its protective effects against LPS (HY-D1056)-mediated inflammation and oxidative stress by upregulating the Nrf2/HO-1 signaling pathway, and it reduces neuroinflammation caused by spinal cord injury (SCI) .

HY-B1960

Canthaxanthin 3 Publications Verification E 161g; all-trans-Canthaxanthin	Reactive Oxygen Species (ROS) Endogenous Metabolite	Inflammation/Immunology Cancer
Canthaxanthin is a red-orange carotenoid with various biological activities, such as antioxidant, antitumor properties.

HY-B1793

Tetraethylammonium chloride 5 Publications Verification	Potassium Channel	Neurological Disease Cancer
Tetraethylammonium chloride is a non-selective potassium channel blocker. Tetraethylammonium chloride is a good substrate for organic cation transporter (OCTN1). Tetraethylammonium chloride antitumor properties .

HY-N7765

Oenothein B	HCV Bacterial Apoptosis Fungal	Infection Inflammation/Immunology Cancer
Oenothein B is a dimeric macrocyclic ellagitannin and has widely pharmacological activities, including antioxidant, anti-inflammatory, antifungal, anti-HCV, and antitumor properties. Oenothein B is a potent and specific inhibitor of poly(ADP-ribose) glycohydrolase .

HY-14452A

Fatostatin hydrobromide Maximum Cited Publications 52 Publications Verification 125B11 hydrobromide	Fatty Acid Synthase (FASN)	Cancer
Fatostatin hydrobromide (125B11 hydrobromide), a specific inhibitor of SREBP activation, impairs the activation of SREBP-1 and SREBP-2. Fatostatin hydrobromide binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs. Fatostatin hydrobromide decreases the transcription of lipogenic genes in cells. Fatostatin hydrobromide possesses antitumor properties, and lowers hyperglycemia in ob/ob mice .

HY-W017316

Terpinen-4-ol 4-Carvomenthenol	Environmental Pollutants Endogenous Metabolite Bacterial Fungal	Infection Inflammation/Immunology Cancer
Terpinen-4-ol (4-Carvomenthenol) is a naturally occurring monoterpene, and can be extracted from a variety of aromatic plants. Terpinen-4-ol is a potent bactericidal agent which possess antifungal , anti-inflammatory and antitumor properties as well, suggesting Terpinen-4-ol to be used for relevant research .

HY-14821

Namitecan ST-1968	Topoisomerase	Cancer
Namitecan is a potent topoisomerase I inhibitor, with antitumor property.

HY-19986

AAL993	VEGFR	Cardiovascular Disease Cancer
IC₅₀s of 130 nM, 23 nM, and 18 nM for VEGFR1, VEGFR2, and VEGFR3, respectively. AAL993 shows less potently inhibits other tyrosine kinases. AAL993 possesses potent antiangiogenic and antitumor properties .

HY-168489

OBI-992 drug-linker	Drug-Linker Conjugates for ADC	Cancer
OBI-992 drug-linker is a drug-linker conjugate composed of a TOP I inhibitor Exatecan (HY-13631) and a linker. OBI-992 drug-linker exhibits antitumor property in mouse models and can be used for synthesis of ADC OBI-992 .

HY-122917

Danshenol A	Aldose Reductase Reactive Oxygen Species (ROS)	Cardiovascular Disease Inflammation/Immunology Cancer
Danshenol A, an abietane-type diterpenoid, is an aldose reductase (AR) inhibitor with an IC₅₀ of 0.1 μM. Danshenol A can protect endothelial cells from oxidative stress by directly scavenging ROS. Danshenol A has anti-inflammatory and antitumor properties. Danshenol A can be used for atherosclerosis research .

HY-W017232

6-Methoxyquinoline p-Quinanisole	Biochemical Assay Reagents	Others
6-Methoxyquinoline consists of a quinoline ring system with a methoxy group attached to the sixth carbon atom. This compound occurs naturally in certain plants, such as tobacco and tea, and has been shown to have biological activities, including antioxidant, anti-inflammatory and antitumor properties. Furthermore, 6-Methoxyquinoline can be used as a building block for the synthesis of other organic compounds, especially those with potential pharmaceutical applications. Due to its ability to bind nucleic acids and proteins, it can also be used as a fluorescent probe in biochemical and biomedical research.

HY-N1940

β-Anhydroicaritin 3 Publications Verification Cycloicaritin	Interleukin Related TNF Receptor MMP	Inflammation/Immunology Cancer
β-Anhydroicaritin is isolated from Boswellia carterii Birdware, has important biological and pharmacological effects, such as antiosteoporosis, estrogen regulation and antitumor properties . β-Anhydroicaritin ameliorates the degradation of periodontal tissue and inhibits the synthesis and secretion of TNF-α and MMP-3 in diabetic rats . β-Anhydroicaritin decreases the overproduction of NO, IL-10, TNF-α, MCP-1 and IL-6 in inperitonitis mice. β-Anhydroicaritin inhibits the elevation of intracellular Ca ²⁺, and markedly decreases iNOS protein expression .

HY-121873

Lavendamycin	Bacterial	Infection
Lavendamycin is a quinolinedione that can be extracted from bacteria and has potent antibacterial and antitumor properties .

HY-B1960R

Canthaxanthin (Standard) E 161g (Standard); all-trans-Canthaxanthin (Standard)	Reference Standards Reactive Oxygen Species (ROS) Endogenous Metabolite	Inflammation/Immunology Cancer
Canthaxanthin (Standard) is the analytical standard of Canthaxanthin. This product is intended for research and analytical applications. Canthaxanthin is a red-orange carotenoid with various biological activities, such as antioxidant, antitumor properties.

HY-14944R

Homoharringtonine (Standard) Omacetaxine mepesuccinate (Standard); HHT (Standard)	Reference Standards STAT	Cancer
Homoharringtonine (Standard) is the analytical standard of Homoharringtonine. This product is intended for research and analytical applications. Homoharringtonine (Omacetaxine mepesuccinate;HHT) is a cytotoxic alkaloid with antitumor properties which acts by inhibiting translation elongation.

HY-105463

Saptomycin D	Antibiotic Bacterial	Infection Cancer
Saptomycin D is an antibiotic with antitumor activity isolated from the Streptomyces sp. HP530 strain. Saptomycin D exhibits potent inhibitory effects against Gram-positive bacteria, while demonstrating weaker inhibitory activities against certain Gram-negative bacteria and yeasts. Saptomycin D also displays remarkable antitumor properties. Saptomycin D is applicable in research within the field of oncology .

HY-W017316R

Terpinen-4-ol (Standard) 4-Carvomenthenol (Standard)	Reference Standards Endogenous Metabolite Bacterial Fungal	Infection Inflammation/Immunology Cancer
Terpinen-4-ol (Standard) is the analytical standard of Terpinen-4-ol. This product is intended for research and analytical applications. Terpinen-4-ol (4-Carvomenthenol) is a naturally occurring monoterpene, and can be extracted from a variety of aromatic plants. Terpinen-4-ol is a potent bactericidal agent which possess antifungal , anti-inflammatory and antitumor properties as well, suggesting Terpinen-4-ol to be used for relevant research .

HY-N0512R

Loganin (Standard) Loganoside (Standard)	Reference Standards Apoptosis Keap1-Nrf2 TNF Receptor Interleukin Related	Neurological Disease Inflammation/Immunology Cancer
Loganin (Standard) is the analytical standard of Loganin. This product is intended for research and analytical applications. Loganin is a type of iridoid glycoside compound that possesses anti-inflammatory, antioxidant, and antitumor properties, and offers protective effects against acute lung injury and pulmonary fibrosis. Loganin exerts its protective effects against LPS (HY-D1056)-mediated inflammation and oxidative stress by upregulating the Nrf2/HO-1 signaling pathway, and it reduces neuroinflammation caused by spinal cord injury (SCI) .

HY-170852

QZ2135	PROTACs RET	Cancer
QZ2135 (compound 20) is a RET-targeted PROTAC degrader with in vivo antitumor properties in a Ba/F3-KIF5B-RET-G810C xenograft mouse model. The degradation activities of QZ2135 targeting KIF5B-RET have DC₅₀ values of 4.7 nM (WT), 17.2 nM (V804M), and 73.8 nM (G810C), respectively. QZ2135 is composed of a target protein ligand (red part) RET ligand-3 (HY-170853), an E3 ligase ligand (blue part) Lenalidomide-F (HY-W039233), and a PROTAC Linker (black part) 7-Iodohept-1-yne (HY-W587352), in which the target protein ligand + linker form a conjugate RET Ligand-Linker Conjugate-1 (HY-170854) .

HY-170806

ERα degrader 12	Estrogen Receptor/ERR	Cancer
ERα degrader 12 (Compound RA3) is an estrogen receptor α (ERα) degrader with antitumor properties. ERα degrader 12 induces pronounced tumor growth inhibition in a breast cancer xenograft mouse model .

HY-179399

β-carboline-ACS81	Apoptosis Mitochondrial Metabolism	Cancer
β-carboline-ACS81 is a β-carboline derivative with potent antitumor properties. β-carboline-ACS81 induces apoptosis through the collapse of mitochondrial membrane potential and arrests cell cycle at G2/M phase in HL-60 cells. β-carboline-ACS81 possesses potent antiproliferative activity against HL-60 cells (IC₅₀ = 1.52 μM). β-carboline-ACS81 can be used for the research of leukemia, histiocytic lymphoma, hepatocellular carcinoma, malignant melanoma, colorectal carcinoma and lung carcinoma .

Cat. No.	Product Name	Type

HY-P9921A

Trastuzumab emtansine (solution) 5+ Cited Publications Ado-Trastuzumab emtansine (solution); PRO132365 (solution); T-DM 1 (solution)	Fluorescent Dyes
Trastuzumab emtansine (Ado-Trastuzumab emtansine) is an antibody-drug conjugate (ADC) that incorporates the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of the microtubule-inhibitory agent DM1 (derivative of maytansine), and the drug-linker conjugate for ADC is SMCC-DM1 (HY-101070). Trastuzumab emtansine can be used for the research of advanced breast cancer .

Cat. No.	Product Name	Type

HY-W017232

6-Methoxyquinoline p-Quinanisole	Biochemical Assay Reagents
6-Methoxyquinoline consists of a quinoline ring system with a methoxy group attached to the sixth carbon atom. This compound occurs naturally in certain plants, such as tobacco and tea, and has been shown to have biological activities, including antioxidant, anti-inflammatory and antitumor properties. Furthermore, 6-Methoxyquinoline can be used as a building block for the synthesis of other organic compounds, especially those with potential pharmaceutical applications. Due to its ability to bind nucleic acids and proteins, it can also be used as a fluorescent probe in biochemical and biomedical research.

6-Methoxyquinoline

p-Quinanisole

Biochemical Assay Reagents

6-Methoxyquinoline consists of a quinoline ring system with a methoxy group attached to the sixth carbon atom. This compound occurs naturally in certain plants, such as tobacco and tea, and has been shown to have biological activities, including antioxidant, anti-inflammatory and antitumor properties. Furthermore, 6-Methoxyquinoline can be used as a building block for the synthesis of other organic compounds, especially those with potential pharmaceutical applications. Due to its ability to bind nucleic acids and proteins, it can also be used as a fluorescent probe in biochemical and biomedical research.

Homoharringtonine Maximum Cited Publications 35 Publications Verification Omacetaxine mepesuccinate; HHT	Alkaloids Pyrrole Alkaloids Classification of Application Fields Plants Cephalotaxaceae Disease Research Fields Cephalotaxus fortunei Hooker Source Classification Cancer	STAT
Homoharringtonine (Omacetaxine mepesuccinate;HHT) is a cytotoxic alkaloid with antitumor properties which acts by inhibiting translation elongation.

Loganin 5 Publications Verification Loganoside	Iridoids Cornaceae Classification of Application Fields Cornus officinalis Sieb. et Zucc. Terpenoids Plants Disease Research Fields Source Classification Cancer	Reactive Oxygen Species (ROS) TNF Receptor Interleukin Related
Loganin is a type of iridoid glycoside compound that possesses anti-inflammatory, antioxidant, and antitumor properties, and offers protective effects against acute lung injury and pulmonary fibrosis. Loganin exerts its protective effects against LPS (HY-D1056)-mediated inflammation and oxidative stress by upregulating the Nrf2/HO-1 signaling pathway, and it reduces neuroinflammation caused by spinal cord injury (SCI) .

Canthaxanthin 3 Publications Verification E 161g; all-trans-Canthaxanthin	Other Terpenoids Microorganisms Animals Classification of Application Fields Terpenoids Pigments Inflammation/Immunology Disease Research Fields Source Classification Food Research	Reactive Oxygen Species (ROS) Endogenous Metabolite
Canthaxanthin is a red-orange carotenoid with various biological activities, such as antioxidant, antitumor properties.

Oenothein B	Infection other families Classification of Application Fields Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Source Classification	HCV Bacterial Apoptosis Fungal
Oenothein B is a dimeric macrocyclic ellagitannin and has widely pharmacological activities, including antioxidant, anti-inflammatory, antifungal, anti-HCV, and antitumor properties. Oenothein B is a potent and specific inhibitor of poly(ADP-ribose) glycohydrolase .

Terpinen-4-ol 4-Carvomenthenol	Structural Classification Classification of Application Fields Camellia sinensis (L.) O. Ktze. Plants Endogenous metabolite Melaleuca alternifolia Other Monoterpenes Terpenoids Myrtaceae Inflammation/Immunology Disease Research Fields Source Classification Theaceae	Environmental Pollutants Endogenous Metabolite Bacterial Fungal
Terpinen-4-ol (4-Carvomenthenol) is a naturally occurring monoterpene, and can be extracted from a variety of aromatic plants. Terpinen-4-ol is a potent bactericidal agent which possess antifungal , anti-inflammatory and antitumor properties as well, suggesting Terpinen-4-ol to be used for relevant research .

Danshenol A	Terpenoids Labiatae Samanea saman (Jacq.) Merr. Diterpenoids Plants	Aldose Reductase Reactive Oxygen Species (ROS)
Danshenol A, an abietane-type diterpenoid, is an aldose reductase (AR) inhibitor with an IC₅₀ of 0.1 μM. Danshenol A can protect endothelial cells from oxidative stress by directly scavenging ROS. Danshenol A has anti-inflammatory and antitumor properties. Danshenol A can be used for atherosclerosis research .

β-Anhydroicaritin 3 Publications Verification Cycloicaritin	Flavonols Flavonoids Classification of Application Fields Plants Burseraceae Inflammation/Immunology Disease Research Fields Boswellia carterii	Interleukin Related TNF Receptor MMP
β-Anhydroicaritin is isolated from Boswellia carterii Birdware, has important biological and pharmacological effects, such as antiosteoporosis, estrogen regulation and antitumor properties . β-Anhydroicaritin ameliorates the degradation of periodontal tissue and inhibits the synthesis and secretion of TNF-α and MMP-3 in diabetic rats . β-Anhydroicaritin decreases the overproduction of NO, IL-10, TNF-α, MCP-1 and IL-6 in inperitonitis mice. β-Anhydroicaritin inhibits the elevation of intracellular Ca ²⁺, and markedly decreases iNOS protein expression .

Lavendamycin	Microorganisms Antibiotics Other Antibiotics Source Classification	Bacterial
Lavendamycin is a quinolinedione that can be extracted from bacteria and has potent antibacterial and antitumor properties .

Canthaxanthin (Standard) E 161g (Standard); all-trans-Canthaxanthin (Standard)	Other Terpenoids Structural Classification Microorganisms Animals Terpenoids Source Classification	Reference Standards Reactive Oxygen Species (ROS) Endogenous Metabolite
Canthaxanthin (Standard) is the analytical standard of Canthaxanthin. This product is intended for research and analytical applications. Canthaxanthin is a red-orange carotenoid with various biological activities, such as antioxidant, antitumor properties.

Homoharringtonine (Standard) Omacetaxine mepesuccinate (Standard); HHT (Standard)	Alkaloids Structural Classification Pyrrole Alkaloids Plants Cephalotaxaceae Cephalotaxus fortunei Hooker Source Classification	Reference Standards STAT
Homoharringtonine (Standard) is the analytical standard of Homoharringtonine. This product is intended for research and analytical applications. Homoharringtonine (Omacetaxine mepesuccinate;HHT) is a cytotoxic alkaloid with antitumor properties which acts by inhibiting translation elongation.

Saptomycin D	Quinones Structural Classification Microorganisms Anthraquinones Source Classification	Antibiotic Bacterial
Saptomycin D is an antibiotic with antitumor activity isolated from the Streptomyces sp. HP530 strain. Saptomycin D exhibits potent inhibitory effects against Gram-positive bacteria, while demonstrating weaker inhibitory activities against certain Gram-negative bacteria and yeasts. Saptomycin D also displays remarkable antitumor properties. Saptomycin D is applicable in research within the field of oncology .

Terpinen-4-ol (Standard) 4-Carvomenthenol (Standard)	Melaleuca alternifolia Structural Classification Natural Products Microorganisms Myrtaceae Camellia sinensis (L.) O. Ktze. Plants Endogenous metabolite Source Classification Theaceae	Reference Standards Endogenous Metabolite Bacterial Fungal
Terpinen-4-ol (Standard) is the analytical standard of Terpinen-4-ol. This product is intended for research and analytical applications. Terpinen-4-ol (4-Carvomenthenol) is a naturally occurring monoterpene, and can be extracted from a variety of aromatic plants. Terpinen-4-ol is a potent bactericidal agent which possess antifungal , anti-inflammatory and antitumor properties as well, suggesting Terpinen-4-ol to be used for relevant research .

Loganin (Standard) Loganoside (Standard)	Structural Classification Iridoids Cornaceae Cornus officinalis Sieb. et Zucc. Terpenoids Plants Source Classification	Reference Standards Apoptosis Keap1-Nrf2 TNF Receptor Interleukin Related
Loganin (Standard) is the analytical standard of Loganin. This product is intended for research and analytical applications. Loganin is a type of iridoid glycoside compound that possesses anti-inflammatory, antioxidant, and antitumor properties, and offers protective effects against acute lung injury and pulmonary fibrosis. Loganin exerts its protective effects against LPS (HY-D1056)-mediated inflammation and oxidative stress by upregulating the Nrf2/HO-1 signaling pathway, and it reduces neuroinflammation caused by spinal cord injury (SCI) .

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antitumor+properties

Inhibitors & Agonists

Fluorescent Dyes

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Natural
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